Gene name: PIF1
Reference locus (S288C): YML061C
Gene biotype: protein_coding
Description: DNA helicase, potent G-quadruplex DNA binder/unwinder; possesses strand annealing activity; promotes DNA synthesis during break-induced replication; important for crossover recombination; translation from different start sites produces mitochondrial and nuclear forms; nuclear form is a catalytic inhibitor of telomerase; mitochondrial form involved in DNA repair and recombination; mutations affect Zn, Fe homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells; Belongs to the helicase family. PIF1 subfamily
Top 10 interactors (score): DNA2 (0.998); SGS1 (0.997); EST2 (0.992); RAD52 (0.988); YKU70 (0.982); POL30 (0.974); RAD51 (0.972); RAD27 (0.968); CDC13 (0.965); POL32 (0.96); SRS2 (0.958); EXO1 (0.942); TOP3 (0.931); MPH1 (0.928); RAD54 (0.928); RAD53 (0.928); CDC9 (0.926); MEC1 (0.924); CDC45 (0.923); YKU80 (0.919)
Homologues (species, bitscore): PIF1 (Homo sapiens, 299.7); Pif1 (Mus musculus, 290.4); pif1 (Danio rerio, 288.1); pif1 (Xenopus tropicalis, 286.6); CG3238 (Drosophila melanogaster, 261.9); pif-1 (Caenorhabditis elegans, 279.3); AT3G51700 (Arabidopsis thaliana, 51.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:142696-145275:- | gene-YML061C_AKU4011 | rna-NM_001182420.1_AKU4011 | cds-NP_013650.1_AKU4011 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000201.1:330880-333459:+ | gene-YML061C_BG1 | rna-NM_001182420.1_BG1 | cds-NP_013650.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:148829-151408:- | gene-YML061C_Bruggeman | rna-NM_001182420.1_Bruggeman | cds-NP_013650.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:150496-153075:- | gene-YML061C_CAT1 | rna-NM_001182420.1_CAT1 | cds-NP_013650.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:142705-145284:- | gene-YML061C_CBS1585 | rna-NM_001182420.1_CBS1585 | cds-NP_013650.1_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:148590-151169:- | gene-YML061C_CBS436 | rna-NM_001182420.1_CBS436 | cds-NP_013650.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:143413-145992:- | gene-YML061C_CBS6412 | rna-NM_001182420.1_CBS6412 | cds-NP_013650.1_CBS6412 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:141888-144467:- | gene-YML061C_CBS6413 | rna-NM_001182420.1_CBS6413 | cds-NP_013650.1_CBS6413 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:143678-146257:- | gene-YML061C_CENPK1137D | rna-NM_001182420.1_CENPK1137D | cds-NP_013650.1_CENPK1137D | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005483.1:142969-145548:- | gene-YML061C_EthanolRed | rna-NM_001182420.1_EthanolRed | cds-NP_013650.1_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:143476-146055:- | gene-YML061C_FaliES1 | rna-NM_001182420.1_FaliES1 | cds-NP_013650.1_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000366.1:11069-13648:+ | gene-YML061C_JAY291 | rna-NM_001182420.1_JAY291 | cds-NP_013650.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:147351-149930:- | gene-YML061C_MUCL30387 | rna-NM_001182420.1_MUCL30387 | cds-NP_013650.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:150537-153116:- | gene-YML061C_MUCL30388 | rna-NM_001182420.1_MUCL30388 | cds-NP_013650.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:142716-145295:- | gene-YML061C_MUCL39482 | rna-NM_001182420.1_MUCL39482 | cds-NP_013650.1_MUCL39482 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:148533-151112:- | gene-YML061C_MUCL42920 | rna-NM_001182420.1_MUCL42920 | cds-NP_013650.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:148907-151486:- | gene-YML061C_NCIM3186 | rna-NM_001182420.1_NCIM3186 | cds-NP_013650.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:143511-146090:- | gene-YML061C_NCYC1407 | rna-NM_001182420.1_NCYC1407 | cds-NP_013650.1_NCYC1407 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:148904-151483:- | gene-YML061C_PE2H3 | rna-NM_001182420.1_PE2H3 | cds-NP_013650.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:148768-151347:- | gene-YML061C_PE2H4 | rna-NM_001182420.1_PE2H4 | cds-NP_013650.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:148953-151532:- | gene-YML061C_S288C | rna-NM_001182420.1_S288C | cds-NP_013650.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000041.1:32730-35309:+ | gene-YML061C_SA1 | rna-NM_001182420.1_SA1 | cds-NP_013650.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:142768-145347:- | gene-YML061C_ThermosaccDry | rna-NM_001182420.1_ThermosaccDry | cds-NP_013650.1_ThermosaccDry | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:147116-149695:- | gene-YML061C_VR1 | rna-NM_001182420.1_VR1 | cds-NP_013650.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000027.1:122305-124884:- | gene-YML061C_ZTW1 | rna-NM_001182420.1_ZTW1 | cds-NP_013650.1_ZTW1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:153914-156493:- | gene-YML061C_Sparadoxus | rna-NM_001182420.1_Sparadoxus | cds-NP_013650.1_Sparadoxus | 90.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |