Gene name: PHB1
Reference locus (S288C): YGR132C
Gene biotype: protein_coding
Description: Prohibitin-1; Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)
Top 10 interactors (score): PHB2 (0.999); TOM40 (0.988); POR1 (0.986); AFG3 (0.979); MGR2 (0.976); POR2 (0.973); YTA12 (0.971); YME1 (0.936); TUF1 (0.913); UPS1 (0.868); MGE1 (0.853); HSP10 (0.839); UPS2 (0.835); PSD1 (0.808); MIC60 (0.787); OMA1 (0.779); PUF3 (0.773); PAM18 (0.762); MCX1 (0.759); SSC1 (0.756)
Homologues (species, bitscore): PHB (Homo sapiens, 313.5); Phb (Mus musculus, 315.5); phb (Danio rerio, 314.7); phb (Xenopus tropicalis, 314.3); l(2)37Cc (Drosophila melanogaster, 317.4); phb-1 (Caenorhabditis elegans, 313.9); PHB4 (Arabidopsis thaliana, 322.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:734566-735429:- | gene-YGR132C_AKU4011 | rna-NM_001181261.3_AKU4011 | cds-NP_011648.3_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000021.1:13339-14202:- | gene-YGR132C_BG1 | rna-NM_001181261.3_BG1 | cds-NP_011648.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:737363-738226:- | gene-YGR132C_Bruggeman | rna-NM_001181261.3_Bruggeman | cds-NP_011648.3_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:736111-736974:- | gene-YGR132C_CAT1 | rna-NM_001181261.3_CAT1 | cds-NP_011648.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:735549-736412:- | gene-YGR132C_CBS1585 | rna-NM_001181261.3_CBS1585 | cds-NP_011648.3_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:738939-739802:- | gene-YGR132C_CBS436 | rna-NM_001181261.3_CBS436 | cds-NP_011648.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:727225-728088:- | gene-YGR132C_CBS6412 | rna-NM_001181261.3_CBS6412 | cds-NP_011648.3_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:732158-733021:- | gene-YGR132C_CBS6413 | rna-NM_001181261.3_CBS6413 | cds-NP_011648.3_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:755301-756164:- | gene-YGR132C_CENPK1137D | rna-NM_001181261.3_CENPK1137D | cds-NP_011648.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:721590-722453:- | gene-YGR132C_EthanolRed | rna-NM_001181261.3_EthanolRed | cds-NP_011648.3_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:725451-726314:- | gene-YGR132C_FaliES1 | rna-NM_001181261.3_FaliES1 | cds-NP_011648.3_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000305.1:7530-8393:+ | gene-YGR132C_JAY291 | rna-NM_001181261.3_JAY291 | cds-NP_011648.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:844503-845366:- | gene-YGR132C_MUCL30387 | rna-NM_001181261.3_MUCL30387 | cds-NP_011648.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:737378-738241:- | gene-YGR132C_MUCL30388 | rna-NM_001181261.3_MUCL30388 | cds-NP_011648.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:731275-732138:- | gene-YGR132C_MUCL39482 | rna-NM_001181261.3_MUCL39482 | cds-NP_011648.3_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:741374-742237:- | gene-YGR132C_MUCL42920 | rna-NM_001181261.3_MUCL42920 | cds-NP_011648.3_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:755589-756452:- | gene-YGR132C_NCIM3186 | rna-NM_001181261.3_NCIM3186 | cds-NP_011648.3_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:725976-726839:- | gene-YGR132C_NCYC1407 | rna-NM_001181261.3_NCYC1407 | cds-NP_011648.3_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:745830-746693:- | gene-YGR132C_PE2H3 | rna-NM_001181261.3_PE2H3 | cds-NP_011648.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:750940-751803:- | gene-YGR132C_PE2H4 | rna-NM_001181261.3_PE2H4 | cds-NP_011648.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:755589-756452:- | gene-YGR132C_S288C | rna-NM_001181261.3_S288C | cds-NP_011648.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000015.1:176725-177588:- | gene-YGR132C_SA1 | rna-NM_001181261.3_SA1 | cds-NP_011648.3_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:746074-746937:- | gene-YGR132C_ThermosaccDry | rna-NM_001181261.3_ThermosaccDry | cds-NP_011648.3_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:849577-850440:- | gene-YGR132C_VR1 | rna-NM_001181261.3_VR1 | cds-NP_011648.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000016.1:48220-49083:- | gene-YGR132C_ZTW1 | rna-NM_001181261.3_ZTW1 | cds-NP_011648.3_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:735879-736742:- | gene-YGR132C_Sparadoxus | rna-NM_001181261.3_Sparadoxus | cds-NP_011648.3_Sparadoxus | 90.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |