Gene name: PFY1
Reference locus (S288C): YOR122C
Gene biotype: protein_coding
Description: Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress; highly conserved protein; human PFN1 (profilin 1) complements temperature sensitive pfy1 mutants, PFN1 mutations are a rare cause of ALS
Top 10 interactors (score): ACT1 (0.999); BNR1 (0.999); COF1 (0.999); BNI1 (0.999); LAS17 (0.994); ARP2 (0.993); TPM1 (0.989); ARP3 (0.983); SRV2 (0.982); BUD6 (0.979); TPM2 (0.977); SAC6 (0.971); CDC42 (0.968); TWF1 (0.967); ABP1 (0.942); RHO1 (0.933); VRP1 (0.931); AIP1 (0.931); CAP2 (0.929); GEA2 (0.929)
Homologues (species, bitscore): PFN4 (Homo sapiens, 68.9); Pfn4 (Mus musculus, 71.2); PFN4 (Danio rerio, 60.8); chic (Drosophila melanogaster, 96.3); pfn-3 (Caenorhabditis elegans, 76.6); PRF5 (Arabidopsis thaliana, 71.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:536362-536951:- | gene-YOR122C_AKU4011 | rna-NM_001183541.3_AKU4011 | cds-NP_014765.3_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000171.1:42320-42909:+ | gene-YOR122C_BG1 | rna-NM_001183541.3_BG1 | cds-NP_014765.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:539910-540499:- | gene-YOR122C_Bruggeman | rna-NM_001183541.3_Bruggeman | cds-NP_014765.3_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:539915-540504:- | gene-YOR122C_CAT1 | rna-NM_001183541.3_CAT1 | cds-NP_014765.3_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:531924-532513:- | gene-YOR122C_CBS1585 | rna-NM_001183541.3_CBS1585 | cds-NP_014765.3_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:536635-537224:- | gene-YOR122C_CBS436 | rna-NM_001183541.3_CBS436 | cds-NP_014765.3_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:530410-530999:- | gene-YOR122C_CBS6412 | rna-NM_001183541.3_CBS6412 | cds-NP_014765.3_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:537706-538295:- | gene-YOR122C_CBS6413 | rna-NM_001183541.3_CBS6413 | cds-NP_014765.3_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:552375-552964:- | gene-YOR122C_CENPK1137D | rna-NM_001183541.3_CENPK1137D | cds-NP_014765.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:532730-533319:- | gene-YOR122C_EthanolRed | rna-NM_001183541.3_EthanolRed | cds-NP_014765.3_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:536426-537015:- | gene-YOR122C_FaliES1 | rna-NM_001183541.3_FaliES1 | cds-NP_014765.3_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000063.1:22251-22840:+ | gene-YOR122C_JAY291 | rna-NM_001183541.3_JAY291 | cds-NP_014765.3_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:544468-545057:- | gene-YOR122C_MUCL30387 | rna-NM_001183541.3_MUCL30387 | cds-NP_014765.3_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:549675-550264:- | gene-YOR122C_MUCL30388 | rna-NM_001183541.3_MUCL30388 | cds-NP_014765.3_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:539319-539908:- | gene-YOR122C_MUCL39482 | rna-NM_001183541.3_MUCL39482 | cds-NP_014765.3_MUCL39482 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:555364-555953:- | gene-YOR122C_MUCL42920 | rna-NM_001183541.3_MUCL42920 | cds-NP_014765.3_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:552187-552776:- | gene-YOR122C_NCIM3186 | rna-NM_001183541.3_NCIM3186 | cds-NP_014765.3_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:545766-546355:- | gene-YOR122C_NCYC1407 | rna-NM_001183541.3_NCYC1407 | cds-NP_014765.3_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:544769-545358:- | gene-YOR122C_PE2H3 | rna-NM_001183541.3_PE2H3 | cds-NP_014765.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:555146-555735:- | gene-YOR122C_PE2H4 | rna-NM_001183541.3_PE2H4 | cds-NP_014765.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:552298-552887:- | gene-YOR122C_S288C | rna-NM_001183541.3_S288C | cds-NP_014765.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000034.1:81837-82426:- | gene-YOR122C_SA1 | rna-NM_001183541.3_SA1 | cds-NP_014765.3_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:535609-536198:- | gene-YOR122C_ThermosaccDry | rna-NM_001183541.3_ThermosaccDry | cds-NP_014765.3_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:537714-538303:- | gene-YOR122C_VR1 | rna-NM_001183541.3_VR1 | cds-NP_014765.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:269546-270135:- | gene-YOR122C_ZTW1 | rna-NM_001183541.3_ZTW1 | cds-NP_014765.3_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:541579-542158:- | gene-YOR122C_Sparadoxus | rna-NM_001183541.3_Sparadoxus | cds-NP_014765.3_Sparadoxus | 95.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |