Gene name: PFK1
Reference locus (S288C): YGR240C
Gene biotype: protein_coding
Description: Alpha subunit of heterooctameric phosphofructokinase; involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily
Top 10 interactors (score): PGI1 (0.999); PFK2 (0.999); FBA1 (0.996); FBP1 (0.994); TPI1 (0.993); PFK26 (0.992); CDC19 (0.99); PFK27 (0.99); TAL1 (0.98); GPH1 (0.979); FBP26 (0.974); HXK2 (0.969); TKL1 (0.969); PYK2 (0.967); PGK1 (0.965); SEC4 (0.963); NQM1 (0.962); YLR345W (0.959); TKL2 (0.957); PCK1 (0.956)
Homologues (species, bitscore): PFKP (Homo sapiens, 615.9); Pfkl (Mus musculus, 606.3); pfkpa (Danio rerio, 617.1); pfkm (Xenopus tropicalis, 601.3); Pfk (Drosophila melanogaster, 585.1); Y71H10A.1 (Caenorhabditis elegans, 583.6); PFK5 (Arabidopsis thaliana, 84.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:936177-939140:- | gene-YGR240C_AKU4011 | rna-NM_001181369.1_AKU4011 | cds-NP_011756.1_AKU4011 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000021.1:216278-219241:- | gene-YGR240C_BG1 | rna-NM_001181369.1_BG1 | cds-NP_011756.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:943770-946733:- | gene-YGR240C_Bruggeman | rna-NM_001181369.1_Bruggeman | cds-NP_011756.1_Bruggeman | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:943312-946275:- | gene-YGR240C_CAT1 | rna-NM_001181369.1_CAT1 | cds-NP_011756.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:939039-942002:- | gene-YGR240C_CBS1585 | rna-NM_001181369.1_CBS1585 | cds-NP_011756.1_CBS1585 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:942693-945656:- | gene-YGR240C_CBS436 | rna-NM_001181369.1_CBS436 | cds-NP_011756.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:929917-932880:- | gene-YGR240C_CBS6412 | rna-NM_001181369.1_CBS6412 | cds-NP_011756.1_CBS6412 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:935968-938931:- | gene-YGR240C_CBS6413 | rna-NM_001181369.1_CBS6413 | cds-NP_011756.1_CBS6413 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:970452-973415:- | gene-YGR240C_CENPK1137D | rna-NM_001181369.1_CENPK1137D | cds-NP_011756.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:924015-926978:- | gene-YGR240C_EthanolRed | rna-NM_001181369.1_EthanolRed | cds-NP_011756.1_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:928821-931784:- | gene-YGR240C_FaliES1 | rna-NM_001181369.1_FaliES1 | cds-NP_011756.1_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000076.1:98506-101469:+ | gene-YGR240C_JAY291 | rna-NM_001181369.1_JAY291 | cds-NP_011756.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:941686-944649:- | gene-YGR240C_MUCL30387 | rna-NM_001181369.1_MUCL30387 | cds-NP_011756.1_MUCL30387 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:940949-943912:- | gene-YGR240C_MUCL30388 | rna-NM_001181369.1_MUCL30388 | cds-NP_011756.1_MUCL30388 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:934165-937128:- | gene-YGR240C_MUCL39482 | rna-NM_001181369.1_MUCL39482 | cds-NP_011756.1_MUCL39482 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:952667-955630:- | gene-YGR240C_MUCL42920 | rna-NM_001181369.1_MUCL42920 | cds-NP_011756.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:970771-973734:- | gene-YGR240C_NCIM3186 | rna-NM_001181369.1_NCIM3186 | cds-NP_011756.1_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:929779-932742:- | gene-YGR240C_NCYC1407 | rna-NM_001181369.1_NCYC1407 | cds-NP_011756.1_NCYC1407 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:954963-957926:- | gene-YGR240C_PE2H3 | rna-NM_001181369.1_PE2H3 | cds-NP_011756.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:959802-962765:- | gene-YGR240C_PE2H4 | rna-NM_001181369.1_PE2H4 | cds-NP_011756.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:970771-973734:- | gene-YGR240C_S288C | rna-NM_001181369.1_S288C | cds-NP_011756.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000045.1:27761-30724:+ | gene-YGR240C_SA1 | rna-NM_001181369.1_SA1 | cds-NP_011756.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:949348-952311:- | gene-YGR240C_ThermosaccDry | rna-NM_001181369.1_ThermosaccDry | cds-NP_011756.1_ThermosaccDry | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:1054609-1057572:- | gene-YGR240C_VR1 | rna-NM_001181369.1_VR1 | cds-NP_011756.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000016.1:250759-253722:- | gene-YGR240C_ZTW1 | rna-NM_001181369.1_ZTW1 | cds-NP_011756.1_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:941570-944533:- | gene-YGR240C_Sparadoxus | rna-NM_001181369.1_Sparadoxus | cds-NP_011756.1_Sparadoxus | 93.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |