Gene name: PFF1
Reference locus (S288C): YBR074W
Gene biotype: protein_coding
Description: Multi-spanning vacuolar membrane protease; glycosylated transmembrane protein bearing homology to the M28 family of metalloproteases; has a lumenal-facing protease domain; proposed role in vacuole physiology
Top 10 interactors (score): APE3 (0.864); DAP2 (0.745); YKL033W-A (0.7); SKG1 (0.699); AFI1 (0.698); PTK1 (0.693); UTP22 (0.679); ECM9 (0.675); BPL1 (0.653); RRT8 (0.616); YPR089W (0.599); MPO1 (0.59); YCR101C (0.584); YJL107C (0.575); YGL242C (0.575); YDR132C (0.573); YDL109C (0.572); PIR5 (0.572); DSD1 (0.568); POF1 (0.567)
Homologues (species, bitscore): ERMP1 (Homo sapiens, 95.1); Ermp1 (Mus musculus, 97.8); Ermp1 (Danio rerio, 101.3); ermp1 (Xenopus tropicalis, 97.1); CG10062 (Drosophila melanogaster, 108.2); B0495.7 (Caenorhabditis elegans, 93.6); AT5G20660 (Arabidopsis thaliana, 105.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:368671-371601:+ | gene-YBR074W_AKU4011 | rna-NM_001178422.2_AKU4011 | cds-NP_009630.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:359647-362577:+ | gene-YBR074W_BG1 | rna-NM_001178422.2_BG1 | cds-NP_009630.3_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:369907-372837:+ | gene-YBR074W_Bruggeman | rna-NM_001178422.2_Bruggeman | cds-NP_009630.3_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:373198-376128:+ | gene-YBR074W_CAT1 | rna-NM_001178422.2_CAT1 | cds-NP_009630.3_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:360955-363885:+ | gene-YBR074W_CBS1585 | rna-NM_001178422.2_CBS1585 | cds-NP_009630.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:369027-371957:+ | gene-YBR074W_CBS436 | rna-NM_001178422.2_CBS436 | cds-NP_009630.3_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:459186-462116:+ | gene-YBR074W_CBS6412 | rna-NM_001178422.2_CBS6412 | cds-NP_009630.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:366096-369026:+ | gene-YBR074W_CBS6413 | rna-NM_001178422.2_CBS6413 | cds-NP_009630.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:380047-382977:+ | gene-YBR074W_CENPK1137D | rna-NM_001178422.2_CENPK1137D | cds-NP_009630.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:495458-498388:+ | gene-YBR074W_EthanolRed | rna-NM_001178422.2_EthanolRed | cds-NP_009630.3_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:384741-387671:+ | gene-YBR074W_FaliES1 | rna-NM_001178422.2_FaliES1 | cds-NP_009630.3_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000124.1:32673-35603:+ | gene-YBR074W_JAY291 | rna-NM_001178422.2_JAY291 | cds-NP_009630.3_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:371057-373987:+ | gene-YBR074W_MUCL30387 | rna-NM_001178422.2_MUCL30387 | cds-NP_009630.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:371096-374026:+ | gene-YBR074W_MUCL30388 | rna-NM_001178422.2_MUCL30388 | cds-NP_009630.3_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:360947-363877:+ | gene-YBR074W_MUCL39482 | rna-NM_001178422.2_MUCL39482 | cds-NP_009630.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:368158-371088:+ | gene-YBR074W_MUCL42920 | rna-NM_001178422.2_MUCL42920 | cds-NP_009630.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:386083-389013:+ | gene-YBR074W_NCIM3186 | rna-NM_001178422.2_NCIM3186 | cds-NP_009630.3_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:361880-364810:+ | gene-YBR074W_NCYC1407 | rna-NM_001178422.2_NCYC1407 | cds-NP_009630.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:374122-377052:+ | gene-YBR074W_PE2H3 | rna-NM_001178422.2_PE2H3 | cds-NP_009630.3_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:371798-374728:+ | gene-YBR074W_PE2H4 | rna-NM_001178422.2_PE2H4 | cds-NP_009630.3_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:386286-389216:+ | gene-YBR074W_S288C | rna-NM_001178422.2_S288C | cds-NP_009630.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000017.1:88296-91226:- | gene-YBR074W_SA1 | rna-NM_001178422.2_SA1 | cds-NP_009630.3_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:383748-386678:+ | gene-YBR074W_ThermosaccDry | rna-NM_001178422.2_ThermosaccDry | cds-NP_009630.3_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:365740-368670:+ | gene-YBR074W_VR1 | rna-NM_001178422.2_VR1 | cds-NP_009630.3_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:359424-362354:+ | gene-YBR074W_ZTW1 | rna-NM_001178422.2_ZTW1 | cds-NP_009630.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:396454-399384:+ | gene-YBR074W_Sparadoxus | rna-NM_001178422.2_Sparadoxus | cds-NP_009630.3_Sparadoxus | 87.4 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |