Gene name: PEP8
Reference locus (S288C): YJL053W
Gene biotype: protein_coding
Description: Carboxypeptidase Y-deficient protein 8; Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
Top 10 interactors (score): VPS35 (0.999); SNX3 (0.999); VPS17 (0.999); VPS29 (0.999); VPS5 (0.999); PEP1 (0.988); YKR078W (0.988); YPT7 (0.987); GYP6 (0.938); YPT6 (0.923); SNX4 (0.911); TLG2 (0.907); VPS8 (0.906); MVP1 (0.899); VPS21 (0.866); VPS34 (0.866); VPS27 (0.865); STP22 (0.862); VTI1 (0.835); SNX41 (0.827)
Homologues (species, bitscore): VPS26B (Homo sapiens, 221.9); Vps26b (Mus musculus, 222.2); vps26a (Danio rerio, 218.0); vps26b (Xenopus tropicalis, 219.2); Vps26 (Drosophila melanogaster, 208.4); vps-26 (Caenorhabditis elegans, 199.1); VPS26B (Arabidopsis thaliana, 194.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:318713-319852:+ | gene-YJL053W_AKU4011 | rna-NM_001181486.1_AKU4011 | cds-NP_012482.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000190.1:293943-295082:- | gene-YJL053W_BG1 | rna-NM_001181486.1_BG1 | cds-NP_012482.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:331296-332435:+ | gene-YJL053W_Bruggeman | rna-NM_001181486.1_Bruggeman | cds-NP_012482.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:336530-337669:+ | gene-YJL053W_CAT1 | rna-NM_001181486.1_CAT1 | cds-NP_012482.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:330367-331506:+ | gene-YJL053W_CBS1585 | rna-NM_001181486.1_CBS1585 | cds-NP_012482.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:348423-349562:+ | gene-YJL053W_CBS436 | rna-NM_001181486.1_CBS436 | cds-NP_012482.1_CBS436 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:319471-320610:+ | gene-YJL053W_CBS6412 | rna-NM_001181486.1_CBS6412 | cds-NP_012482.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:320818-321957:+ | gene-YJL053W_CBS6413 | rna-NM_001181486.1_CBS6413 | cds-NP_012482.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:318366-319505:+ | gene-YJL053W_CENPK1137D | rna-NM_001181486.1_CENPK1137D | cds-NP_012482.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:322550-323689:+ | gene-YJL053W_EthanolRed | rna-NM_001181486.1_EthanolRed | cds-NP_012482.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:334125-335264:+ | gene-YJL053W_FaliES1 | rna-NM_001181486.1_FaliES1 | cds-NP_012482.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000138.1:131763-132902:+ | gene-YJL053W_JAY291 | rna-NM_001181486.1_JAY291 | cds-NP_012482.1_JAY291 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:332451-333590:+ | gene-YJL053W_MUCL30387 | rna-NM_001181486.1_MUCL30387 | cds-NP_012482.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:328489-329628:+ | gene-YJL053W_MUCL30388 | rna-NM_001181486.1_MUCL30388 | cds-NP_012482.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:323121-324260:+ | gene-YJL053W_MUCL39482 | rna-NM_001181486.1_MUCL39482 | cds-NP_012482.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:329816-330955:+ | gene-YJL053W_MUCL42920 | rna-NM_001181486.1_MUCL42920 | cds-NP_012482.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:335877-337016:+ | gene-YJL053W_NCIM3186 | rna-NM_001181486.1_NCIM3186 | cds-NP_012482.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:321817-322956:+ | gene-YJL053W_NCYC1407 | rna-NM_001181486.1_NCYC1407 | cds-NP_012482.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:334217-335356:+ | gene-YJL053W_PE2H3 | rna-NM_001181486.1_PE2H3 | cds-NP_012482.1_PE2H3 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:333862-335001:+ | gene-YJL053W_PE2H4 | rna-NM_001181486.1_PE2H4 | cds-NP_012482.1_PE2H4 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:335898-337037:+ | gene-YJL053W_S288C | rna-NM_001181486.1_S288C | cds-NP_012482.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000003.1:131780-132919:+ | gene-YJL053W_SA1 | rna-NM_001181486.1_SA1 | cds-NP_012482.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:327538-328677:+ | gene-YJL053W_ThermosaccDry | rna-NM_001181486.1_ThermosaccDry | cds-NP_012482.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:330028-331167:+ | gene-YJL053W_VR1 | rna-NM_001181486.1_VR1 | cds-NP_012482.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:308915-310054:+ | gene-YJL053W_ZTW1 | rna-NM_001181486.1_ZTW1 | cds-NP_012482.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:332997-334136:+ | gene-YJL053W_Sparadoxus | rna-NM_001181486.1_Sparadoxus | cds-NP_012482.1_Sparadoxus | 90.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |