Gene name: PEP4
Reference locus (S288C): YPL154C
Gene biotype: protein_coding
Description: Saccharopepsin; Vacuolar aspartyl protease (proteinase A); required for posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; plays a protective role in acetic acid induced apoptosis; synthesized as a zymogen, self-activates
Top 10 interactors (score): PRC1 (0.998); PRB1 (0.991); PAI3 (0.984); KEX2 (0.917); URA3 (0.911); CUE5 (0.906); POT1 (0.904); KAR2 (0.903); BUD16 (0.9); DCK1 (0.9); CAR1 (0.9); CAN1 (0.896); YBR139W (0.888); APE1 (0.868); PHO8 (0.867); DOA4 (0.866); PEP1 (0.859); ATG15 (0.853); GLK1 (0.849); YPT7 (0.842)
Homologues (species, bitscore): CTSD (Homo sapiens, 299.3); Ctse (Mus musculus, 291.2); NAPSA (Danio rerio, 297.0); ctsd (Xenopus tropicalis, 300.1); cathD (Drosophila melanogaster, 319.3); asp-4 (Caenorhabditis elegans, 293.1); AT4G04460 (Arabidopsis thaliana, 262.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:237370-238587:- | gene-YPL154C_AKU4011 | rna-NM_001183968.1_AKU4011 | cds-NP_015171.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:443046-444263:- | gene-YPL154C_BG1 | rna-NM_001183968.1_BG1 | cds-NP_015171.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:263363-264580:- | gene-YPL154C_Bruggeman | rna-NM_001183968.1_Bruggeman | cds-NP_015171.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:260035-261252:- | gene-YPL154C_CAT1 | rna-NM_001183968.1_CAT1 | cds-NP_015171.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:241433-242650:- | gene-YPL154C_CBS1585 | rna-NM_001183968.1_CBS1585 | cds-NP_015171.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:256098-257315:- | gene-YPL154C_CBS436 | rna-NM_001183968.1_CBS436 | cds-NP_015171.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:246111-247328:- | gene-YPL154C_CBS6412 | rna-NM_001183968.1_CBS6412 | cds-NP_015171.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:238073-239290:- | gene-YPL154C_CBS6413 | rna-NM_001183968.1_CBS6413 | cds-NP_015171.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:259598-260815:- | gene-YPL154C_CENPK1137D | rna-NM_001183968.1_CENPK1137D | cds-NP_015171.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:236060-237277:- | gene-YPL154C_EthanolRed | rna-NM_001183968.1_EthanolRed | cds-NP_015171.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:243652-244869:- | gene-YPL154C_FaliES1 | rna-NM_001183968.1_FaliES1 | cds-NP_015171.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000007.1:120982-122199:+ | gene-YPL154C_JAY291 | rna-NM_001183968.1_JAY291 | cds-NP_015171.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:254606-255823:- | gene-YPL154C_MUCL30387 | rna-NM_001183968.1_MUCL30387 | cds-NP_015171.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:252623-253840:- | gene-YPL154C_MUCL30388 | rna-NM_001183968.1_MUCL30388 | cds-NP_015171.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:234762-235979:- | gene-YPL154C_MUCL39482 | rna-NM_001183968.1_MUCL39482 | cds-NP_015171.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:291493-292710:- | gene-YPL154C_MUCL42920 | rna-NM_001183968.1_MUCL42920 | cds-NP_015171.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:259697-260914:- | gene-YPL154C_NCIM3186 | rna-NM_001183968.1_NCIM3186 | cds-NP_015171.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:241225-242442:- | gene-YPL154C_NCYC1407 | rna-NM_001183968.1_NCYC1407 | cds-NP_015171.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:248659-249876:- | gene-YPL154C_PE2H3 | rna-NM_001183968.1_PE2H3 | cds-NP_015171.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:248302-249519:- | gene-YPL154C_PE2H4 | rna-NM_001183968.1_PE2H4 | cds-NP_015171.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:259714-260931:- | gene-YPL154C_S288C | rna-NM_001183968.1_S288C | cds-NP_015171.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000012.1:112756-113973:+ | gene-YPL154C_SA1 | rna-NM_001183968.1_SA1 | cds-NP_015171.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:243450-244667:- | gene-YPL154C_ThermosaccDry | rna-NM_001183968.1_ThermosaccDry | cds-NP_015171.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:258430-259647:- | gene-YPL154C_VR1 | rna-NM_001183968.1_VR1 | cds-NP_015171.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:242779-243996:- | gene-YPL154C_ZTW1 | rna-NM_001183968.1_ZTW1 | cds-NP_015171.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:244453-245670:- | gene-YPL154C_Sparadoxus | rna-NM_001183968.1_Sparadoxus | cds-NP_015171.1_Sparadoxus | 91.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |