Gene name: PDI1
Reference locus (S288C): YCL043C
Gene biotype: protein_coding
Description: Protein disulfide isomerase; multifunctional oxidoreductase of the ER lumen, essential for disulfide bond formation in secretory and cell-surface proteins, processing of non-native disulfide bonds; Ero1p activator; complexes with exomannosidase, Mnl1p to facilitate the recognition of misfolded glycoproteins and the trimming of glycan Man8GlcNAc2 to Man7GlcNAc2 on substrates, thereby accelerating ERAD; PDI1 has a paralog, EUG1, that arose from the whole genome duplication
Top 10 interactors (score): ERO1 (0.999); CNE1 (0.999); KAR2 (0.999); MNL1 (0.998); LHS1 (0.997); SEC61 (0.993); MPD2 (0.99); CPR5 (0.981); ERD2 (0.964); SEC63 (0.963); ERV29 (0.96); CPR2 (0.959); WBP1 (0.958); SEC62 (0.955); SCJ1 (0.953); MPD1 (0.947); HRD1 (0.94); IRE1 (0.927); HAC1 (0.924); YOS9 (0.904)
Homologues (species, bitscore): PDIA4 (Homo sapiens, 205.3); Pdia4 (Mus musculus, 212.6); pdia3 (Danio rerio, 208.8); p4hb (Xenopus tropicalis, 214.5); Pdi (Drosophila melanogaster, 204.1); pdi-3 (Caenorhabditis elegans, 209.9); PDIL1-2 (Arabidopsis thaliana, 199.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005297.1:49934-51526:- | gene-YCL043C_AKU4011 | rna-NM_001178688.1_AKU4011 | cds-NP_009887.1_AKU4011 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000198.1:4089-5681:- | gene-YCL043C_BG1 | rna-NM_001178688.1_BG1 | cds-NP_009887.1_BG1 | 97.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005505.1:37797-39365:- | gene-YCL043C_Bruggeman | rna-NM_001178688.1_Bruggeman | cds-NP_009887.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005521.1:49818-51386:- | gene-YCL043C_CAT1 | rna-NM_001178688.1_CAT1 | cds-NP_009887.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005361.1:50631-52223:- | gene-YCL043C_CBS1585 | rna-NM_001178688.1_CBS1585 | cds-NP_009887.1_CBS1585 | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005345.1:49163-50731:- | gene-YCL043C_CBS436 | rna-NM_001178688.1_CBS436 | cds-NP_009887.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005329.1:38429-40021:- | gene-YCL043C_CBS6412 | rna-NM_001178688.1_CBS6412 | cds-NP_009887.1_CBS6412 | 98.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005313.1:49457-51049:- | gene-YCL043C_CBS6413 | rna-NM_001178688.1_CBS6413 | cds-NP_009887.1_CBS6413 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001524.1:48218-49786:- | gene-YCL043C_CENPK1137D | rna-NM_001178688.1_CENPK1137D | cds-NP_009887.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005473.1:48192-49784:- | gene-YCL043C_EthanolRed | rna-NM_001178688.1_EthanolRed | cds-NP_009887.1_EthanolRed | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005537.1:48957-50549:- | gene-YCL043C_FaliES1 | rna-NM_001178688.1_FaliES1 | cds-NP_009887.1_FaliES1 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000225.1:33821-35389:+ | gene-YCL043C_JAY291 | rna-NM_001178688.1_JAY291 | cds-NP_009887.1_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005409.1:36401-37993:- | gene-YCL043C_MUCL30387 | rna-NM_001178688.1_MUCL30387 | cds-NP_009887.1_MUCL30387 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005441.1:36675-38243:- | gene-YCL043C_MUCL30388 | rna-NM_001178688.1_MUCL30388 | cds-NP_009887.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005281.1:51024-52616:- | gene-YCL043C_MUCL39482 | rna-NM_001178688.1_MUCL39482 | cds-NP_009887.1_MUCL39482 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005425.1:37191-38759:- | gene-YCL043C_MUCL42920 | rna-NM_001178688.1_MUCL42920 | cds-NP_009887.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011812.1:48285-49853:- | gene-YCL043C_NCIM3186 | rna-NM_001178688.1_NCIM3186 | cds-NP_009887.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005265.1:51354-52946:- | gene-YCL043C_NCYC1407 | rna-NM_001178688.1_NCYC1407 | cds-NP_009887.1_NCYC1407 | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994142.1:49120-50688:- | gene-YCL043C_PE2H3 | rna-NM_001178688.1_PE2H3 | cds-NP_009887.1_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999874.1:49077-50645:- | gene-YCL043C_PE2H4 | rna-NM_001178688.1_PE2H4 | cds-NP_009887.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001135.5:48653-50221:- | gene-YCL043C_S288C | rna-NM_001178688.1_S288C | cds-NP_009887.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000061.1:35799-37367:- | gene-YCL043C_SA1 | rna-NM_001178688.1_SA1 | cds-NP_009887.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005489.1:49274-50866:- | gene-YCL043C_ThermosaccDry | rna-NM_001178688.1_ThermosaccDry | cds-NP_009887.1_ThermosaccDry | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005457.1:55592-57184:- | gene-YCL043C_VR1 | rna-NM_001178688.1_VR1 | cds-NP_009887.1_VR1 | 98.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000004.1:49482-51080:- | gene-YCL043C_ZTW1 | rna-NM_001178688.1_ZTW1 | cds-NP_009887.1_ZTW1 | 97.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047489.1:79161-80738:- | gene-YCL043C_Sparadoxus | rna-NM_001178688.1_Sparadoxus | cds-NP_009887.1_Sparadoxus | 91.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |