Gene name: PDC1
Reference locus (S288C): YLR044C
Gene biotype: protein_coding
Description: Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo; Belongs to the TPP enzyme family
Top 10 interactors (score): PDC6 (0.999); CDC19 (0.999); PDC5 (0.999); ADH1 (0.998); FBA1 (0.996); ENO2 (0.983); ADH2 (0.979); ALD6 (0.977); PDB1 (0.976); ENO1 (0.975); TEF1 (0.974); SFA1 (0.973); ADH3 (0.971); ARO8 (0.971); ARO9 (0.971); PYK2 (0.971); TDH3 (0.97); PDA1 (0.969); PGI1 (0.965); TDH2 (0.961)
Homologues (species, bitscore): HACL1 (Homo sapiens, 98.6); Hacl1 (Mus musculus, 96.3); hacl1 (Danio rerio, 88.2); hacl1 (Xenopus tropicalis, 92.4); CG11208 (Drosophila melanogaster, 91.7); B0334.3 (Caenorhabditis elegans, 95.1); AT5G01320 (Arabidopsis thaliana, 295.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:214877-216568:- | gene-YLR044C_AKU4011 | rna-NM_001181931.1_AKU4011 | cds-NP_013145.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:178015-179706:- | gene-YLR044C_BG1 | rna-NM_001181931.1_BG1 | cds-NP_013145.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:224787-226478:- | gene-YLR044C_Bruggeman | rna-NM_001181931.1_Bruggeman | cds-NP_013145.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:225112-226803:- | gene-YLR044C_CAT1 | rna-NM_001181931.1_CAT1 | cds-NP_013145.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:222015-223706:- | gene-YLR044C_CBS1585 | rna-NM_001181931.1_CBS1585 | cds-NP_013145.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:212650-214341:- | gene-YLR044C_CBS436 | rna-NM_001181931.1_CBS436 | cds-NP_013145.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:220424-222115:- | gene-YLR044C_CBS6412 | rna-NM_001181931.1_CBS6412 | cds-NP_013145.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:222276-223967:- | gene-YLR044C_CBS6413 | rna-NM_001181931.1_CBS6413 | cds-NP_013145.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:211681-213372:- | gene-YLR044C_CENPK1137D | rna-NM_001181931.1_CENPK1137D | cds-NP_013145.1_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:214393-216084:- | gene-YLR044C_EthanolRed | rna-NM_001181931.1_EthanolRed | cds-NP_013145.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:214279-215970:- | gene-YLR044C_FaliES1 | rna-NM_001181931.1_FaliES1 | cds-NP_013145.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000289.1:1-1283:+ | gene-YLR044C_JAY291 | rna-NM_001181931.1_JAY291 | cds-NP_013145.1_JAY291 | 75.7 | 75.8 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:222138-223829:- | gene-YLR044C_MUCL30387 | rna-NM_001181931.1_MUCL30387 | cds-NP_013145.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:229802-231493:- | gene-YLR044C_MUCL30388 | rna-NM_001181931.1_MUCL30388 | cds-NP_013145.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:222510-224201:- | gene-YLR044C_MUCL39482 | rna-NM_001181931.1_MUCL39482 | cds-NP_013145.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:222416-224107:- | gene-YLR044C_MUCL42920 | rna-NM_001181931.1_MUCL42920 | cds-NP_013145.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:232364-234055:- | gene-YLR044C_NCIM3186 | rna-NM_001181931.1_NCIM3186 | cds-NP_013145.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:214569-216260:- | gene-YLR044C_NCYC1407 | rna-NM_001181931.1_NCYC1407 | cds-NP_013145.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:220438-222129:- | gene-YLR044C_PE2H3 | rna-NM_001181931.1_PE2H3 | cds-NP_013145.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:220179-221870:- | gene-YLR044C_PE2H4 | rna-NM_001181931.1_PE2H4 | cds-NP_013145.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:232390-234081:- | gene-YLR044C_S288C | rna-NM_001181931.1_S288C | cds-NP_013145.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000046.1:58281-59972:- | gene-YLR044C_SA1 | rna-NM_001181931.1_SA1 | cds-NP_013145.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:214467-216158:- | gene-YLR044C_ThermosaccDry | rna-NM_001181931.1_ThermosaccDry | cds-NP_013145.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:227886-229577:- | gene-YLR044C_VR1 | rna-NM_001181931.1_VR1 | cds-NP_013145.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:213824-215515:- | gene-YLR044C_ZTW1 | rna-NM_001181931.1_ZTW1 | cds-NP_013145.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:222707-224398:- | gene-YLR044C_Sparadoxus | rna-NM_001181931.1_Sparadoxus | cds-NP_013145.1_Sparadoxus | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |