Gene name: PDA1
Reference locus (S288C): YER178W
Gene biotype: protein_coding
Description: E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex; catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose; PDH complex is concentrated in spots within the mitochondrial matrix, often near the ERMES complex and near peroxisomes
Top 10 interactors (score): PDB1 (0.999); LPD1 (0.999); PDX1 (0.999); LAT1 (0.999); KGD1 (0.993); PGI1 (0.987); CDC19 (0.979); PYC2 (0.971); MAE1 (0.971); PDC1 (0.969); PYK2 (0.968); PTC5 (0.961); FBA1 (0.96); PYC1 (0.958); CYB2 (0.957); KGD2 (0.946); PDC6 (0.94); THI3 (0.938); PDC5 (0.934); ZWF1 (0.931)
Homologues (species, bitscore): PDHA1 (Homo sapiens, 384.0); Pdha1 (Mus musculus, 385.6); pdha1b (Danio rerio, 395.6); pdha1 (Xenopus tropicalis, 380.2); CG7024 (Drosophila melanogaster, 374.8); pdha-1 (Caenorhabditis elegans, 407.9); At1g59900 (Arabidopsis thaliana, 389.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:528332-529594:+ | gene-YER178W_AKU4011 | rna-NM_001179068.3_AKU4011 | cds-NP_011105.4_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000176.1:3776-5038:- | gene-YER178W_BG1 | rna-NM_001179068.3_BG1 | cds-NP_011105.4_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:541078-542340:+ | gene-YER178W_Bruggeman | rna-NM_001179068.3_Bruggeman | cds-NP_011105.4_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:527665-528927:+ | gene-YER178W_CAT1 | rna-NM_001179068.3_CAT1 | cds-NP_011105.4_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:528136-529398:+ | gene-YER178W_CBS1585 | rna-NM_001179068.3_CBS1585 | cds-NP_011105.4_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:538027-539289:+ | gene-YER178W_CBS436 | rna-NM_001179068.3_CBS436 | cds-NP_011105.4_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:526113-527375:+ | gene-YER178W_CBS6412 | rna-NM_001179068.3_CBS6412 | cds-NP_011105.4_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:534682-535944:+ | gene-YER178W_CBS6413 | rna-NM_001179068.3_CBS6413 | cds-NP_011105.4_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:544583-545845:+ | gene-YER178W_CENPK1137D | rna-NM_001179068.3_CENPK1137D | cds-NP_011105.4_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:534299-535561:+ | gene-YER178W_EthanolRed | rna-NM_001179068.3_EthanolRed | cds-NP_011105.4_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:535235-536497:+ | gene-YER178W_FaliES1 | rna-NM_001179068.3_FaliES1 | cds-NP_011105.4_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000169.1:3400-4662:- | gene-YER178W_JAY291 | rna-NM_001179068.3_JAY291 | cds-NP_011105.4_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:528388-529650:+ | gene-YER178W_MUCL30387 | rna-NM_001179068.3_MUCL30387 | cds-NP_011105.4_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:531301-532563:+ | gene-YER178W_MUCL30388 | rna-NM_001179068.3_MUCL30388 | cds-NP_011105.4_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:524094-525356:+ | gene-YER178W_MUCL39482 | rna-NM_001179068.3_MUCL39482 | cds-NP_011105.4_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:538620-539882:+ | gene-YER178W_MUCL42920 | rna-NM_001179068.3_MUCL42920 | cds-NP_011105.4_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:546816-548078:+ | gene-YER178W_NCIM3186 | rna-NM_001179068.3_NCIM3186 | cds-NP_011105.4_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:533550-534812:+ | gene-YER178W_NCYC1407 | rna-NM_001179068.3_NCYC1407 | cds-NP_011105.4_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:549490-550752:+ | gene-YER178W_PE2H3 | rna-NM_001179068.3_PE2H3 | cds-NP_011105.4_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:539423-540685:+ | gene-YER178W_PE2H4 | rna-NM_001179068.3_PE2H4 | cds-NP_011105.4_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:546817-548079:+ | gene-YER178W_S288C | rna-NM_001179068.3_S288C | cds-NP_011105.4_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000030.1:98972-100234:+ | gene-YER178W_SA1 | rna-NM_001179068.3_SA1 | cds-NP_011105.4_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:536035-537297:+ | gene-YER178W_ThermosaccDry | rna-NM_001179068.3_ThermosaccDry | cds-NP_011105.4_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:529326-530588:+ | gene-YER178W_VR1 | rna-NM_001179068.3_VR1 | cds-NP_011105.4_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000011.1:48888-50150:+ | gene-YER178W_ZTW1 | rna-NM_001179068.3_ZTW1 | cds-NP_011105.4_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:537305-538567:+ | gene-YER178W_Sparadoxus | rna-NM_001179068.3_Sparadoxus | cds-NP_011105.4_Sparadoxus | 93.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |