Gene name: PCH2
Reference locus (S288C): YBR186W
Gene biotype: protein_coding
Description: Pachytene checkpoint protein 2; Hexameric ring ATPase that remodels chromosome axis protein Hop1p; nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in rDNA; required for meiotic double-stranded break formation
Top 10 interactors (score): MAD2 (0.998); SPO11 (0.995); RAD51 (0.983); DMC1 (0.982); MSH4 (0.977); HOP1 (0.973); DPS1 (0.962); ZIP1 (0.955); MSH5 (0.954); MLH3 (0.941); AMA1 (0.929); MUS81 (0.926); RAD54 (0.92); DOT1 (0.918); CDC20 (0.917); YCG1 (0.915); CDH1 (0.914); RFC2 (0.904); ASE1 (0.904); UBC11 (0.901)
Homologues (species, bitscore): TRIP13 (Homo sapiens, 191.4); Trip13 (Mus musculus, 193.0); trip13 (Danio rerio, 188.7); trip13 (Xenopus tropicalis, 195.7); pch2 (Drosophila melanogaster, 194.5); pch-2 (Caenorhabditis elegans, 171.4); AT4G24710 (Arabidopsis thaliana, 196.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:583922-585729:+ | gene-YBR186W_AKU4011 | rna-NM_001178534.1_AKU4011 | cds-NP_009745.2_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:573928-575735:+ | gene-YBR186W_BG1 | rna-NM_001178534.1_BG1 | cds-NP_009745.2_BG1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:389783-391590:+ | gene-YBR186W_Bruggeman | rna-NM_001178534.1_Bruggeman | cds-NP_009745.2_Bruggeman | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:589189-590996:+ | gene-YBR186W_CAT1 | rna-NM_001178534.1_CAT1 | cds-NP_009745.2_CAT1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:575703-577510:+ | gene-YBR186W_CBS1585 | rna-NM_001178534.1_CBS1585 | cds-NP_009745.2_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:583256-585063:+ | gene-YBR186W_CBS436 | rna-NM_001178534.1_CBS436 | cds-NP_009745.2_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:672312-674119:+ | gene-YBR186W_CBS6412 | rna-NM_001178534.1_CBS6412 | cds-NP_009745.2_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:581509-583316:+ | gene-YBR186W_CBS6413 | rna-NM_001178534.1_CBS6413 | cds-NP_009745.2_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:594327-596134:+ | gene-YBR186W_CENPK1137D | rna-NM_001178534.1_CENPK1137D | cds-NP_009745.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:709079-710886:+ | gene-YBR186W_EthanolRed | rna-NM_001178534.1_EthanolRed | cds-NP_009745.2_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:599990-601797:+ | gene-YBR186W_FaliES1 | rna-NM_001178534.1_FaliES1 | cds-NP_009745.2_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000104.1:4421-6228:- | gene-YBR186W_JAY291 | rna-NM_001178534.1_JAY291 | cds-NP_009745.2_JAY291 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:588464-590271:+ | gene-YBR186W_MUCL30387 | rna-NM_001178534.1_MUCL30387 | cds-NP_009745.2_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:605539-607346:+ | gene-YBR186W_MUCL30388 | rna-NM_001178534.1_MUCL30388 | cds-NP_009745.2_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:574076-575883:+ | gene-YBR186W_MUCL39482 | rna-NM_001178534.1_MUCL39482 | cds-NP_009745.2_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:583498-585305:+ | gene-YBR186W_MUCL42920 | rna-NM_001178534.1_MUCL42920 | cds-NP_009745.2_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:600350-602157:+ | gene-YBR186W_NCIM3186 | rna-NM_001178534.1_NCIM3186 | cds-NP_009745.2_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:576184-577991:+ | gene-YBR186W_NCYC1407 | rna-NM_001178534.1_NCYC1407 | cds-NP_009745.2_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:588800-590607:+ | gene-YBR186W_PE2H3 | rna-NM_001178534.1_PE2H3 | cds-NP_009745.2_PE2H3 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:586476-588283:+ | gene-YBR186W_PE2H4 | rna-NM_001178534.1_PE2H4 | cds-NP_009745.2_PE2H4 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:600553-602360:+ | gene-YBR186W_S288C | rna-NM_001178534.1_S288C | cds-NP_009745.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000080.1:8251-10058:+ | gene-YBR186W_SA1 | rna-NM_001178534.1_SA1 | cds-NP_009745.2_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:599000-600807:+ | gene-YBR186W_ThermosaccDry | rna-NM_001178534.1_ThermosaccDry | cds-NP_009745.2_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:580177-581984:+ | gene-YBR186W_VR1 | rna-NM_001178534.1_VR1 | cds-NP_009745.2_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:573616-575424:+ | gene-YBR186W_ZTW1 | rna-NM_001178534.1_ZTW1 | cds-NP_009745.2_ZTW1 | 99.7 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:615455-617252:+ | gene-YBR186W_Sparadoxus | rna-NM_001178534.1_Sparadoxus | cds-NP_009745.2_Sparadoxus | 87.9 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |