Gene name: PCA1
Reference locus (S288C): YBR295W
Gene biotype: protein_coding
Description: Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily
Top 10 interactors (score): SCL1 (0.914); PRE7 (0.905); PUP3 (0.905); PRE1 (0.905); PUP2 (0.905); PRE6 (0.905); PRE5 (0.903); PRE10 (0.903); PUP1 (0.903); PRE2 (0.903); PRE9 (0.903); PRE3 (0.901); PRE8 (0.9); PRE4 (0.9); ATX1 (0.889); YNR021W (0.862); YPK9 (0.845); CCS1 (0.755); CAD1 (0.717); KRI1 (0.713)
Homologues (species, bitscore): ATP7B (Homo sapiens, 318.5); Atp7b (Mus musculus, 317.8); atp7b (Danio rerio, 327.8); atp7b (Xenopus tropicalis, 332.4); ATP7 (Drosophila melanogaster, 272.3); cua-1 (Caenorhabditis elegans, 322.8); HMA5 (Arabidopsis thaliana, 340.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:777182-780832:+ | gene-YBR295W_AKU4011 | rna-NM_001178643.2_AKU4011 | cds-NP_009854.2_AKU4011 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000066.1:148144-151794:+ | gene-YBR295W_BG1 | rna-NM_001178643.2_BG1 | cds-NP_009854.2_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:778254-781904:+ | gene-YBR295W_Bruggeman | rna-NM_001178643.2_Bruggeman | cds-NP_009854.2_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:782007-785657:+ | gene-YBR295W_CAT1 | rna-NM_001178643.2_CAT1 | cds-NP_009854.2_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:768749-772399:+ | gene-YBR295W_CBS1585 | rna-NM_001178643.2_CBS1585 | cds-NP_009854.2_CBS1585 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:775136-778786:+ | gene-YBR295W_CBS436 | rna-NM_001178643.2_CBS436 | cds-NP_009854.2_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:863298-866948:+ | gene-YBR295W_CBS6412 | rna-NM_001178643.2_CBS6412 | cds-NP_009854.2_CBS6412 | 98.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:774777-778427:+ | gene-YBR295W_CBS6413 | rna-NM_001178643.2_CBS6413 | cds-NP_009854.2_CBS6413 | 98.3 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:786748-790398:+ | gene-YBR295W_CENPK1137D | rna-NM_001178643.2_CENPK1137D | cds-NP_009854.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:900218-903969:+ | gene-YBR295W_EthanolRed | rna-NM_001178643.2_EthanolRed | cds-NP_009854.2_EthanolRed | 95.8 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:793565-797323:+ | gene-YBR295W_FaliES1 | rna-NM_001178643.2_FaliES1 | cds-NP_009854.2_FaliES1 | 95.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000067.1:6970-10620:- | gene-YBR295W_JAY291 | rna-NM_001178643.2_JAY291 | cds-NP_009854.2_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:780323-783973:+ | gene-YBR295W_MUCL30387 | rna-NM_001178643.2_MUCL30387 | cds-NP_009854.2_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:797655-801305:+ | gene-YBR295W_MUCL30388 | rna-NM_001178643.2_MUCL30388 | cds-NP_009854.2_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:767056-770706:+ | gene-YBR295W_MUCL39482 | rna-NM_001178643.2_MUCL39482 | cds-NP_009854.2_MUCL39482 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:776865-780515:+ | gene-YBR295W_MUCL42920 | rna-NM_001178643.2_MUCL42920 | cds-NP_009854.2_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:792646-796296:+ | gene-YBR295W_NCIM3186 | rna-NM_001178643.2_NCIM3186 | cds-NP_009854.2_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:768944-772593:+ | gene-YBR295W_NCYC1407 | rna-NM_001178643.2_NCYC1407 | cds-NP_009854.2_NCYC1407 | 98.3 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:792034-795684:+ | gene-YBR295W_PE2H3 | rna-NM_001178643.2_PE2H3 | cds-NP_009854.2_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:789710-793360:+ | gene-YBR295W_PE2H4 | rna-NM_001178643.2_PE2H4 | cds-NP_009854.2_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:792849-796499:+ | gene-YBR295W_S288C | rna-NM_001178643.2_S288C | cds-NP_009854.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000019.1:147990-151640:+ | gene-YBR295W_SA1 | rna-NM_001178643.2_SA1 | cds-NP_009854.2_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:792557-796315:+ | gene-YBR295W_ThermosaccDry | rna-NM_001178643.2_ThermosaccDry | cds-NP_009854.2_ThermosaccDry | 95.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:772732-776382:+ | gene-YBR295W_VR1 | rna-NM_001178643.2_VR1 | cds-NP_009854.2_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:765371-769021:+ | gene-YBR295W_ZTW1 | rna-NM_001178643.2_ZTW1 | cds-NP_009854.2_ZTW1 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:808841-812512:+ | gene-YBR295W_Sparadoxus | rna-NM_001178643.2_Sparadoxus | cds-NP_009854.2_Sparadoxus | 83.7 | 99.5 | Verified | 1 | 1 | 1 | False | True | False | False | False |