Gene name: PAH1
Reference locus (S288C): YMR165C
Gene biotype: protein_coding
Description: Phosphatidic acid phosphohydrolase 1; Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; regulates phospholipid synthesis, nuclear/ER membrane growth, lipid droplet formation, triacylglycerol synthesis, vacuolar homeostasis and cell wall integrity; phosphorylated by Pho85p/Pho80p, Cdc28p/Cyclin B, PKA, PKC, and CKII, regulating activity, localization, and proteosomal degradation; homolog of mammalian lipins 1 and 2; human homologs LPIN1, LPIN2, LPIN3 complement the null
Top 10 interactors (score): DGK1 (0.998); DGA1 (0.997); DPP1 (0.997); LPP1 (0.996); SPO7 (0.995); NEM1 (0.993); LRO1 (0.993); SLC1 (0.989); SPO14 (0.989); CDS1 (0.985); CPT1 (0.982); EPT1 (0.981); SCT1 (0.974); PHO85 (0.96); ALE1 (0.957); GPT2 (0.95); TAZ1 (0.935); ARE2 (0.931); TGL4 (0.922); GDE1 (0.919)
Homologues (species, bitscore): LPIN3 (Homo sapiens, 264.6); Lpin3 (Mus musculus, 267.7); si:ch73-21k16.1 (Danio rerio, 282.7); lpin1 (Xenopus tropicalis, 253.8); Lpin (Drosophila melanogaster, 254.6); lpin-1 (Caenorhabditis elegans, 263.8); PAH1 (Arabidopsis thaliana, 236.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:629789-632377:- | gene-YMR165C_AKU4011 | rna-NM_001182669.1_AKU4011 | cds-NP_013888.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000068.1:40452-43040:+ | gene-YMR165C_BG1 | rna-NM_001182669.1_BG1 | cds-NP_013888.1_BG1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:572717-575305:- | gene-YMR165C_Bruggeman | rna-NM_001182669.1_Bruggeman | cds-NP_013888.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:575719-578307:- | gene-YMR165C_CAT1 | rna-NM_001182669.1_CAT1 | cds-NP_013888.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:562470-565058:- | gene-YMR165C_CBS1585 | rna-NM_001182669.1_CBS1585 | cds-NP_013888.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:566335-568923:- | gene-YMR165C_CBS436 | rna-NM_001182669.1_CBS436 | cds-NP_013888.1_CBS436 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:675087-677675:- | gene-YMR165C_CBS6412 | rna-NM_001182669.1_CBS6412 | cds-NP_013888.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:561020-563608:- | gene-YMR165C_CBS6413 | rna-NM_001182669.1_CBS6413 | cds-NP_013888.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:584519-587107:- | gene-YMR165C_CENPK1137D | rna-NM_001182669.1_CENPK1137D | cds-NP_013888.1_CENPK1137D | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:622645-625233:- | gene-YMR165C_EthanolRed | rna-NM_001182669.1_EthanolRed | cds-NP_013888.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:567799-570387:- | gene-YMR165C_FaliES1 | rna-NM_001182669.1_FaliES1 | cds-NP_013888.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000292.1:7336-9924:+ | gene-YMR165C_JAY291 | rna-NM_001182669.1_JAY291 | cds-NP_013888.1_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:567691-570279:- | gene-YMR165C_MUCL30387 | rna-NM_001182669.1_MUCL30387 | cds-NP_013888.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:573344-575932:- | gene-YMR165C_MUCL30388 | rna-NM_001182669.1_MUCL30388 | cds-NP_013888.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:563156-565744:- | gene-YMR165C_MUCL39482 | rna-NM_001182669.1_MUCL39482 | cds-NP_013888.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:569984-572572:- | gene-YMR165C_MUCL42920 | rna-NM_001182669.1_MUCL42920 | cds-NP_013888.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:589994-592582:- | gene-YMR165C_NCIM3186 | rna-NM_001182669.1_NCIM3186 | cds-NP_013888.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:562858-565446:- | gene-YMR165C_NCYC1407 | rna-NM_001182669.1_NCYC1407 | cds-NP_013888.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:573200-575788:- | gene-YMR165C_PE2H3 | rna-NM_001182669.1_PE2H3 | cds-NP_013888.1_PE2H3 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:573662-576250:- | gene-YMR165C_PE2H4 | rna-NM_001182669.1_PE2H4 | cds-NP_013888.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:590040-592628:- | gene-YMR165C_S288C | rna-NM_001182669.1_S288C | cds-NP_013888.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000002.1:213630-216224:+ | gene-YMR165C_SA1 | rna-NM_001182669.1_SA1 | cds-NP_013888.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:563531-566119:- | gene-YMR165C_ThermosaccDry | rna-NM_001182669.1_ThermosaccDry | cds-NP_013888.1_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:575686-578274:- | gene-YMR165C_VR1 | rna-NM_001182669.1_VR1 | cds-NP_013888.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000027.1:538154-540742:- | gene-YMR165C_ZTW1 | rna-NM_001182669.1_ZTW1 | cds-NP_013888.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:581822-584407:- | gene-YMR165C_Sparadoxus | rna-NM_001182669.1_Sparadoxus | cds-NP_013888.1_Sparadoxus | 88.7 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |