Gene name: PAC1
Reference locus (S288C): YOR269W
Gene biotype: protein_coding
Description: Platelet-activating factor acetylhydrolase ib subunit alpha; Nuclear distribution protein PAC1; Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly
Top 10 interactors (score): DYN1 (0.999); DYN2 (0.997); BIM1 (0.997); BIK1 (0.996); STU2 (0.995); NUM1 (0.987); NDL1 (0.985); NIP100 (0.984); NDC80 (0.974); BUB3 (0.969); PXR1 (0.962); KAR9 (0.949); KIP3 (0.944); JNM1 (0.941); CIN8 (0.93); KIP2 (0.915); TGL4 (0.9); TGL5 (0.9); CPT1 (0.9); DYN3 (0.894)
Homologues (species, bitscore): PAFAH1B1 (Homo sapiens, 146.0); Pafah1b1 (Mus musculus, 146.7); pafah1b1a (Danio rerio, 146.0); pafah1b1 (Xenopus tropicalis, 149.1); Lis-1 (Drosophila melanogaster, 136.3); lis-1 (Caenorhabditis elegans, 121.7); WDR5a (Arabidopsis thaliana, 63.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:817195-818679:+ | gene-YOR269W_AKU4011 | rna-NM_001183688.1_AKU4011 | cds-NP_014912.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000123.1:219161-220645:+ | gene-YOR269W_BG1 | rna-NM_001183688.1_BG1 | cds-NP_014912.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:802630-804114:+ | gene-YOR269W_Bruggeman | rna-NM_001183688.1_Bruggeman | cds-NP_014912.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:803302-804786:+ | gene-YOR269W_CAT1 | rna-NM_001183688.1_CAT1 | cds-NP_014912.1_CAT1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:800214-801698:+ | gene-YOR269W_CBS1585 | rna-NM_001183688.1_CBS1585 | cds-NP_014912.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:798863-800347:+ | gene-YOR269W_CBS436 | rna-NM_001183688.1_CBS436 | cds-NP_014912.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:797067-798551:+ | gene-YOR269W_CBS6412 | rna-NM_001183688.1_CBS6412 | cds-NP_014912.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:805922-807406:+ | gene-YOR269W_CBS6413 | rna-NM_001183688.1_CBS6413 | cds-NP_014912.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:826156-827640:+ | gene-YOR269W_CENPK1137D | rna-NM_001183688.1_CENPK1137D | cds-NP_014912.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:793323-794807:+ | gene-YOR269W_EthanolRed | rna-NM_001183688.1_EthanolRed | cds-NP_014912.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:798722-800206:+ | gene-YOR269W_FaliES1 | rna-NM_001183688.1_FaliES1 | cds-NP_014912.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000381.1:26707-28191:- | gene-YOR269W_JAY291 | rna-NM_001183688.1_JAY291 | cds-NP_014912.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:806867-808351:+ | gene-YOR269W_MUCL30387 | rna-NM_001183688.1_MUCL30387 | cds-NP_014912.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:814843-816327:+ | gene-YOR269W_MUCL30388 | rna-NM_001183688.1_MUCL30388 | cds-NP_014912.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:807559-809043:+ | gene-YOR269W_MUCL39482 | rna-NM_001183688.1_MUCL39482 | cds-NP_014912.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:817047-818531:+ | gene-YOR269W_MUCL42920 | rna-NM_001183688.1_MUCL42920 | cds-NP_014912.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:826274-827758:+ | gene-YOR269W_NCIM3186 | rna-NM_001183688.1_NCIM3186 | cds-NP_014912.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:807765-809249:+ | gene-YOR269W_NCYC1407 | rna-NM_001183688.1_NCYC1407 | cds-NP_014912.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:806843-808327:+ | gene-YOR269W_PE2H3 | rna-NM_001183688.1_PE2H3 | cds-NP_014912.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:817220-818704:+ | gene-YOR269W_PE2H4 | rna-NM_001183688.1_PE2H4 | cds-NP_014912.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:826385-827869:+ | gene-YOR269W_S288C | rna-NM_001183688.1_S288C | cds-NP_014912.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000006.1:236404-237888:+ | gene-YOR269W_SA1 | rna-NM_001183688.1_SA1 | cds-NP_014912.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:797905-799389:+ | gene-YOR269W_ThermosaccDry | rna-NM_001183688.1_ThermosaccDry | cds-NP_014912.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:861283-862767:+ | gene-YOR269W_VR1 | rna-NM_001183688.1_VR1 | cds-NP_014912.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:530793-532277:+ | gene-YOR269W_ZTW1 | rna-NM_001183688.1_ZTW1 | cds-NP_014912.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:803529-805013:+ | gene-YOR269W_Sparadoxus | rna-NM_001183688.1_Sparadoxus | cds-NP_014912.1_Sparadoxus | 90.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |