Gene name: OSM1
Reference locus (S288C): YJR051W
Gene biotype: protein_coding
Description: Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; has two translation start sites, one at the annotated start codon which produces an ER-targeted form required for anaerobic growth, and one at codon 32 which produces a mitochondrially-targeted form; OSM1 has a paralog, FRD1, that arose from the whole genome duplication; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily
Top 10 interactors (score): SDH2 (0.884); KGD1 (0.875); PXA1 (0.847); RAD7 (0.844); UTR1 (0.814); CYC1 (0.811); ERO1 (0.785); FRD1 (0.781); ISY1 (0.77); UTR5 (0.755); SHH3 (0.754); SDH3 (0.754); TED1 (0.719); LSC1 (0.716); FAA2 (0.702); UTR4 (0.69); FOX2 (0.688); CYT1 (0.685); ADH4 (0.671); SDH5 (0.654)
Homologues (species, bitscore): SDHA (Homo sapiens, 95.9); Sdha (Mus musculus, 98.6); sdha (Danio rerio, 90.1); sdha (Xenopus tropicalis, 58.5); SdhA (Drosophila melanogaster, 96.3); F48E8.3 (Caenorhabditis elegans, 292.0); SDH1-1 (Arabidopsis thaliana, 95.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:501549-503054:+ | gene-YJR051W_AKU4011 | rna-NM_001181709.1_AKU4011 | cds-NP_012585.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000190.1:109937-111442:- | gene-YJR051W_BG1 | rna-NM_001181709.1_BG1 | cds-NP_012585.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:515599-517104:+ | gene-YJR051W_Bruggeman | rna-NM_001181709.1_Bruggeman | cds-NP_012585.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:519767-521272:+ | gene-YJR051W_CAT1 | rna-NM_001181709.1_CAT1 | cds-NP_012585.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:513619-515124:+ | gene-YJR051W_CBS1585 | rna-NM_001181709.1_CBS1585 | cds-NP_012585.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:532078-533583:+ | gene-YJR051W_CBS436 | rna-NM_001181709.1_CBS436 | cds-NP_012585.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:501334-502839:+ | gene-YJR051W_CBS6412 | rna-NM_001181709.1_CBS6412 | cds-NP_012585.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:503579-505084:+ | gene-YJR051W_CBS6413 | rna-NM_001181709.1_CBS6413 | cds-NP_012585.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:512225-513730:+ | gene-YJR051W_CENPK1137D | rna-NM_001181709.1_CENPK1137D | cds-NP_012585.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:506461-507966:+ | gene-YJR051W_EthanolRed | rna-NM_001181709.1_EthanolRed | cds-NP_012585.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:517678-519183:+ | gene-YJR051W_FaliES1 | rna-NM_001181709.1_FaliES1 | cds-NP_012585.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000352.1:9238-10743:- | gene-YJR051W_JAY291 | rna-NM_001181709.1_JAY291 | cds-NP_012585.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:516137-517642:+ | gene-YJR051W_MUCL30387 | rna-NM_001181709.1_MUCL30387 | cds-NP_012585.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:512689-514194:+ | gene-YJR051W_MUCL30388 | rna-NM_001181709.1_MUCL30388 | cds-NP_012585.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:507077-508582:+ | gene-YJR051W_MUCL39482 | rna-NM_001181709.1_MUCL39482 | cds-NP_012585.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:511847-513352:+ | gene-YJR051W_MUCL42920 | rna-NM_001181709.1_MUCL42920 | cds-NP_012585.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:529840-531345:+ | gene-YJR051W_NCIM3186 | rna-NM_001181709.1_NCIM3186 | cds-NP_012585.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:504934-506439:+ | gene-YJR051W_NCYC1407 | rna-NM_001181709.1_NCYC1407 | cds-NP_012585.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:522830-524335:+ | gene-YJR051W_PE2H3 | rna-NM_001181709.1_PE2H3 | cds-NP_012585.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:516526-518031:+ | gene-YJR051W_PE2H4 | rna-NM_001181709.1_PE2H4 | cds-NP_012585.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:529861-531366:+ | gene-YJR051W_S288C | rna-NM_001181709.1_S288C | cds-NP_012585.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000110.1:11428-12933:+ | gene-YJR051W_SA1 | rna-NM_001181709.1_SA1 | cds-NP_012585.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:511366-512871:+ | gene-YJR051W_ThermosaccDry | rna-NM_001181709.1_ThermosaccDry | cds-NP_012585.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:513862-515367:+ | gene-YJR051W_VR1 | rna-NM_001181709.1_VR1 | cds-NP_012585.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:491249-492754:+ | gene-YJR051W_ZTW1 | rna-NM_001181709.1_ZTW1 | cds-NP_012585.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:517580-519085:+ | gene-YJR051W_Sparadoxus | rna-NM_001181709.1_Sparadoxus | cds-NP_012585.1_Sparadoxus | 90.1 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |