Gene name: OSH6
Reference locus (S288C): YKR003W
Gene biotype: protein_coding
Description: Member of an oxysterol-binding protein family; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion; OSH6 has a paralog, OSH7, that arose from the whole genome duplication
Top 10 interactors (score): OSH7 (0.999); SAC1 (0.875); SCS2 (0.866); IST2 (0.857); VPS4 (0.819); SEC14 (0.807); PIK1 (0.765); PAP1 (0.661); LCB1 (0.601); STT4 (0.59); UPS1 (0.568); TCB3 (0.559); NCR1 (0.542); YKR011C (0.541); KES1 (0.513); TPO4 (0.508); HES1 (0.499); LYS12 (0.495); ART5 (0.495); NSP1 (0.468)
Homologues (species, bitscore): OSBPL5 (Homo sapiens, 226.1); Osbpl9 (Mus musculus, 212.6); osbpl5 (Danio rerio, 208.0); osbpl8 (Xenopus tropicalis, 212.6); CG42668 (Drosophila melanogaster, 211.1); obr-3 (Caenorhabditis elegans, 211.1); ORP4C (Arabidopsis thaliana, 91.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:431403-432749:+ | gene-YKR003W_AKU4011 | rna-NM_001179793.1_AKU4011 | cds-NP_012928.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000113.1:211178-212524:- | gene-YKR003W_BG1 | rna-NM_001179793.1_BG1 | cds-NP_012928.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:453088-454434:+ | gene-YKR003W_Bruggeman | rna-NM_001179793.1_Bruggeman | cds-NP_012928.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:448193-449539:+ | gene-YKR003W_CAT1 | rna-NM_001179793.1_CAT1 | cds-NP_012928.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:444122-445468:+ | gene-YKR003W_CBS1585 | rna-NM_001179793.1_CBS1585 | cds-NP_012928.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:442962-444308:+ | gene-YKR003W_CBS436 | rna-NM_001179793.1_CBS436 | cds-NP_012928.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:428280-429626:+ | gene-YKR003W_CBS6412 | rna-NM_001179793.1_CBS6412 | cds-NP_012928.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:443975-445321:+ | gene-YKR003W_CBS6413 | rna-NM_001179793.1_CBS6413 | cds-NP_012928.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:445058-446404:+ | gene-YKR003W_CENPK1137D | rna-NM_001179793.1_CENPK1137D | cds-NP_012928.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:441884-443230:+ | gene-YKR003W_EthanolRed | rna-NM_001179793.1_EthanolRed | cds-NP_012928.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:443973-445319:+ | gene-YKR003W_FaliES1 | rna-NM_001179793.1_FaliES1 | cds-NP_012928.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000120.1:11506-12852:- | gene-YKR003W_JAY291 | rna-NM_001179793.1_JAY291 | cds-NP_012928.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:452402-453748:+ | gene-YKR003W_MUCL30387 | rna-NM_001179793.1_MUCL30387 | cds-NP_012928.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:448013-449359:+ | gene-YKR003W_MUCL30388 | rna-NM_001179793.1_MUCL30388 | cds-NP_012928.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:443439-444785:+ | gene-YKR003W_MUCL39482 | rna-NM_001179793.1_MUCL39482 | cds-NP_012928.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:449247-450593:+ | gene-YKR003W_MUCL42920 | rna-NM_001179793.1_MUCL42920 | cds-NP_012928.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:445370-446716:+ | gene-YKR003W_NCIM3186 | rna-NM_001179793.1_NCIM3186 | cds-NP_012928.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:443647-444993:+ | gene-YKR003W_NCYC1407 | rna-NM_001179793.1_NCYC1407 | cds-NP_012928.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:468300-469646:+ | gene-YKR003W_PE2H3 | rna-NM_001179793.1_PE2H3 | cds-NP_012928.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:453042-454388:+ | gene-YKR003W_PE2H4 | rna-NM_001179793.1_PE2H4 | cds-NP_012928.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:445381-446727:+ | gene-YKR003W_S288C | rna-NM_001179793.1_S288C | cds-NP_012928.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000027.1:123646-124992:+ | gene-YKR003W_SA1 | rna-NM_001179793.1_SA1 | cds-NP_012928.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:444071-445417:+ | gene-YKR003W_ThermosaccDry | rna-NM_001179793.1_ThermosaccDry | cds-NP_012928.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:443323-444669:+ | gene-YKR003W_VR1 | rna-NM_001179793.1_VR1 | cds-NP_012928.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:442110-443456:+ | gene-YKR003W_ZTW1 | rna-NM_001179793.1_ZTW1 | cds-NP_012928.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:467051-468394:+ | gene-YKR003W_Sparadoxus | rna-NM_001179793.1_Sparadoxus | cds-NP_012928.1_Sparadoxus | 91.9 | 99.7 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |