Gene name: OSH2
Reference locus (S288C): YDL019C
Gene biotype: protein_coding
Description: Member of an oxysterol-binding protein family with seven members; in S. cerevisiae, family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane and at the nuclear envelope; regulated by sterol binding; OSH2 has a paralog, SWH1, that arose from the whole genome duplication
Top 10 interactors (score): SCS2 (0.994); STT4 (0.9); SAC1 (0.894); PIK1 (0.813); MYO5 (0.81); KES1 (0.788); INO1 (0.78); OPI1 (0.78); LSB6 (0.753); ARF1 (0.731); SCS22 (0.715); EFR3 (0.7); HES1 (0.697); OSH3 (0.689); PAH1 (0.646); SWH1 (0.645); YPP1 (0.618); SLM2 (0.571); YPT7 (0.568); ICE2 (0.563)
Homologues (species, bitscore): OSBP (Homo sapiens, 284.3); Osbp (Mus musculus, 284.6); osbpl2a (Danio rerio, 282.0); osbp (Xenopus tropicalis, 280.4); Osbp (Drosophila melanogaster, 268.1); obr-1 (Caenorhabditis elegans, 256.1); ORP1A (Arabidopsis thaliana, 278.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:403743-407594:- | gene-YDL019C_AKU4011 | rna-NM_001180078.1_AKU4011 | cds-NP_010265.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:142283-146134:+ | gene-YDL019C_BG1 | rna-NM_001180078.1_BG1 | cds-NP_010265.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:424315-428166:- | gene-YDL019C_Bruggeman | rna-NM_001180078.1_Bruggeman | cds-NP_010265.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:417203-421054:- | gene-YDL019C_CAT1 | rna-NM_001180078.1_CAT1 | cds-NP_010265.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:400156-404007:- | gene-YDL019C_CBS1585 | rna-NM_001180078.1_CBS1585 | cds-NP_010265.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:417687-421538:- | gene-YDL019C_CBS436 | rna-NM_001180078.1_CBS436 | cds-NP_010265.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:397925-401776:- | gene-YDL019C_CBS6412 | rna-NM_001180078.1_CBS6412 | cds-NP_010265.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:419922-423773:- | gene-YDL019C_CBS6413 | rna-NM_001180078.1_CBS6413 | cds-NP_010265.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:416522-420373:- | gene-YDL019C_CENPK1137D | rna-NM_001180078.1_CENPK1137D | cds-NP_010265.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:412575-416426:- | gene-YDL019C_EthanolRed | rna-NM_001180078.1_EthanolRed | cds-NP_010265.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:418767-422618:- | gene-YDL019C_FaliES1 | rna-NM_001180078.1_FaliES1 | cds-NP_010265.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000370.1:33257-37108:- | gene-YDL019C_JAY291 | rna-NM_001180078.1_JAY291 | cds-NP_010265.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:418204-422055:- | gene-YDL019C_MUCL30387 | rna-NM_001180078.1_MUCL30387 | cds-NP_010265.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:408660-412511:- | gene-YDL019C_MUCL30388 | rna-NM_001180078.1_MUCL30388 | cds-NP_010265.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:401830-405681:- | gene-YDL019C_MUCL39482 | rna-NM_001180078.1_MUCL39482 | cds-NP_010265.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:323713-327564:- | gene-YDL019C_MUCL42920 | rna-NM_001180078.1_MUCL42920 | cds-NP_010265.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:417586-421437:- | gene-YDL019C_NCIM3186 | rna-NM_001180078.1_NCIM3186 | cds-NP_010265.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:401252-405103:- | gene-YDL019C_NCYC1407 | rna-NM_001180078.1_NCYC1407 | cds-NP_010265.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:408739-412590:- | gene-YDL019C_PE2H3 | rna-NM_001180078.1_PE2H3 | cds-NP_010265.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:408097-411948:- | gene-YDL019C_PE2H4 | rna-NM_001180078.1_PE2H4 | cds-NP_010265.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:417663-421514:- | gene-YDL019C_S288C | rna-NM_001180078.1_S288C | cds-NP_010265.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000010.1:13449-17300:+ | gene-YDL019C_SA1 | rna-NM_001180078.1_SA1 | cds-NP_010265.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:418227-422078:- | gene-YDL019C_ThermosaccDry | rna-NM_001180078.1_ThermosaccDry | cds-NP_010265.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:421237-425088:- | gene-YDL019C_VR1 | rna-NM_001180078.1_VR1 | cds-NP_010265.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:416127-419978:- | gene-YDL019C_ZTW1 | rna-NM_001180078.1_ZTW1 | cds-NP_010265.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:420221-424069:- | gene-YDL019C_Sparadoxus | rna-NM_001180078.1_Sparadoxus | cds-NP_010265.1_Sparadoxus | 90.5 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |