Gene name: ORM2
Reference locus (S288C): YLR350W
Gene biotype: protein_coding
Description: Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress; ORM2 has a paralog, ORM1, that arose from the whole genome duplication
Top 10 interactors (score): ORM1 (0.999); LCB1 (0.998); LCB2 (0.997); TSC3 (0.993); SAC1 (0.992); YPK1 (0.886); LAG1 (0.83); YPK2 (0.82); DPL1 (0.79); LAC1 (0.79); PKH1 (0.742); AUR1 (0.733); ISC1 (0.726); FPK1 (0.724); ERF2 (0.722); SHR5 (0.72); PMR1 (0.7); SUR2 (0.695); LCB3 (0.69); CCW12 (0.648)
Homologues (species, bitscore): ORMDL3 (Homo sapiens, 82.8); Ormdl3 (Mus musculus, 84.0); ormdl3 (Danio rerio, 77.4); ormdl1 (Xenopus tropicalis, 79.7); ORMDL (Drosophila melanogaster, 81.3); AT5G42000 (Arabidopsis thaliana, 85.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:778291-778941:+ | gene-YLR350W_AKU4011 | rna-NM_001182239.1_AKU4011 | cds-NP_013454.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000048.1:10344-10994:+ | gene-YLR350W_BG1 | rna-NM_001182239.1_BG1 | cds-NP_013454.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:815037-815687:+ | gene-YLR350W_Bruggeman | rna-NM_001182239.1_Bruggeman | cds-NP_013454.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:812073-812723:+ | gene-YLR350W_CAT1 | rna-NM_001182239.1_CAT1 | cds-NP_013454.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:813282-813932:+ | gene-YLR350W_CBS1585 | rna-NM_001182239.1_CBS1585 | cds-NP_013454.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:797477-798127:+ | gene-YLR350W_CBS436 | rna-NM_001182239.1_CBS436 | cds-NP_013454.1_CBS436 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:850291-850941:+ | gene-YLR350W_CBS6412 | rna-NM_001182239.1_CBS6412 | cds-NP_013454.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:814174-814824:+ | gene-YLR350W_CBS6413 | rna-NM_001182239.1_CBS6413 | cds-NP_013454.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:813446-814096:+ | gene-YLR350W_CENPK1137D | rna-NM_001182239.1_CENPK1137D | cds-NP_013454.1_CENPK1137D | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:770854-771504:+ | gene-YLR350W_EthanolRed | rna-NM_001182239.1_EthanolRed | cds-NP_013454.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:799659-800309:+ | gene-YLR350W_FaliES1 | rna-NM_001182239.1_FaliES1 | cds-NP_013454.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000161.1:10218-10868:+ | gene-YLR350W_JAY291 | rna-NM_001182239.1_JAY291 | cds-NP_013454.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:813038-813688:+ | gene-YLR350W_MUCL30387 | rna-NM_001182239.1_MUCL30387 | cds-NP_013454.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:818380-819030:+ | gene-YLR350W_MUCL30388 | rna-NM_001182239.1_MUCL30388 | cds-NP_013454.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:814501-815151:+ | gene-YLR350W_MUCL39482 | rna-NM_001182239.1_MUCL39482 | cds-NP_013454.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:809762-810412:+ | gene-YLR350W_MUCL42920 | rna-NM_001182239.1_MUCL42920 | cds-NP_013454.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:828704-829354:+ | gene-YLR350W_NCIM3186 | rna-NM_001182239.1_NCIM3186 | cds-NP_013454.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:823721-824371:+ | gene-YLR350W_NCYC1407 | rna-NM_001182239.1_NCYC1407 | cds-NP_013454.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:810637-811287:+ | gene-YLR350W_PE2H3 | rna-NM_001182239.1_PE2H3 | cds-NP_013454.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:810381-811031:+ | gene-YLR350W_PE2H4 | rna-NM_001182239.1_PE2H4 | cds-NP_013454.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:828730-829380:+ | gene-YLR350W_S288C | rna-NM_001182239.1_S288C | cds-NP_013454.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000007.1:219328-219978:- | gene-YLR350W_SA1 | rna-NM_001182239.1_SA1 | cds-NP_013454.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:802497-803147:+ | gene-YLR350W_ThermosaccDry | rna-NM_001182239.1_ThermosaccDry | cds-NP_013454.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:815746-816396:+ | gene-YLR350W_VR1 | rna-NM_001182239.1_VR1 | cds-NP_013454.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:139937-140587:+ | gene-YLR350W_ZTW1 | rna-NM_001182239.1_ZTW1 | cds-NP_013454.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:788504-789157:+ | gene-YLR350W_Sparadoxus | rna-NM_001182239.1_Sparadoxus | cds-NP_013454.1_Sparadoxus | 90.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |