Gene name: NUC1
Reference locus (S288C): YJL208C
Gene biotype: protein_coding
Description: Major mitochondrial nuclease; has RNAse and DNA endo- and exonucleolytic activities; roles in mitochondrial recombination, apoptosis and maintenance of polyploidy; involved in fragmentation of genomic DNA during PND (programmed nuclear destruction); encodes ortholog of mammalian endoG; Belongs to the DNA/RNA non-specific endonuclease family
Top 10 interactors (score): AIF1 (0.972); NMA111 (0.962); MCA1 (0.943); RAD27 (0.939); TRZ1 (0.927); BIR1 (0.874); BXI1 (0.816); DIN7 (0.811); YBL055C (0.804); YMR099C (0.775); PUF3 (0.763); FIS1 (0.747); NDI1 (0.744); RRP46 (0.72); EMP70 (0.716); TRM11 (0.691); CYC7 (0.683); PET9 (0.674); CYC1 (0.667); RRP6 (0.664)
Homologues (species, bitscore): ENDOG (Homo sapiens, 186.4); Endog (Mus musculus, 181.8); endog (Danio rerio, 193.0); endog (Xenopus tropicalis, 183.7); EndoG (Drosophila melanogaster, 212.6); cps-6 (Caenorhabditis elegans, 201.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:28597-29586:- | gene-YJL208C_AKU4011 | rna-NM_001181641.1_AKU4011 | cds-NP_012327.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000181.1:5866-6855:- | gene-YJL208C_BG1 | rna-NM_001181641.1_BG1 | cds-NP_012327.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:40398-41387:- | gene-YJL208C_Bruggeman | rna-NM_001181641.1_Bruggeman | cds-NP_012327.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:43145-44134:- | gene-YJL208C_CAT1 | rna-NM_001181641.1_CAT1 | cds-NP_012327.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:34227-35216:- | gene-YJL208C_CBS1585 | rna-NM_001181641.1_CBS1585 | cds-NP_012327.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:58968-59957:- | gene-YJL208C_CBS436 | rna-NM_001181641.1_CBS436 | cds-NP_012327.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:30710-31699:- | gene-YJL208C_CBS6412 | rna-NM_001181641.1_CBS6412 | cds-NP_012327.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:31706-32695:- | gene-YJL208C_CBS6413 | rna-NM_001181641.1_CBS6413 | cds-NP_012327.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:22659-23648:- | gene-YJL208C_CENPK1137D | rna-NM_001181641.1_CENPK1137D | cds-NP_012327.1_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:32893-33882:- | gene-YJL208C_EthanolRed | rna-NM_001181641.1_EthanolRed | cds-NP_012327.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:38170-39159:- | gene-YJL208C_FaliES1 | rna-NM_001181641.1_FaliES1 | cds-NP_012327.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000301.1:29322-30311:- | gene-YJL208C_JAY291 | rna-NM_001181641.1_JAY291 | cds-NP_012327.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:42131-43120:- | gene-YJL208C_MUCL30387 | rna-NM_001181641.1_MUCL30387 | cds-NP_012327.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:38286-39275:- | gene-YJL208C_MUCL30388 | rna-NM_001181641.1_MUCL30388 | cds-NP_012327.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:32967-33956:- | gene-YJL208C_MUCL39482 | rna-NM_001181641.1_MUCL39482 | cds-NP_012327.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:37572-38561:- | gene-YJL208C_MUCL42920 | rna-NM_001181641.1_MUCL42920 | cds-NP_012327.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:40173-41162:- | gene-YJL208C_NCIM3186 | rna-NM_001181641.1_NCIM3186 | cds-NP_012327.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:31583-32572:- | gene-YJL208C_NCYC1407 | rna-NM_001181641.1_NCYC1407 | cds-NP_012327.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:44268-45257:- | gene-YJL208C_PE2H3 | rna-NM_001181641.1_PE2H3 | cds-NP_012327.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:38156-39145:- | gene-YJL208C_PE2H4 | rna-NM_001181641.1_PE2H4 | cds-NP_012327.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:40194-41183:- | gene-YJL208C_S288C | rna-NM_001181641.1_S288C | cds-NP_012327.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000022.1:112707-113696:+ | gene-YJL208C_SA1 | rna-NM_001181641.1_SA1 | cds-NP_012327.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:31366-32355:- | gene-YJL208C_ThermosaccDry | rna-NM_001181641.1_ThermosaccDry | cds-NP_012327.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:38224-39213:- | gene-YJL208C_VR1 | rna-NM_001181641.1_VR1 | cds-NP_012327.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:18949-19938:- | gene-YJL208C_ZTW1 | rna-NM_001181641.1_ZTW1 | cds-NP_012327.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:43110-44099:- | gene-YJL208C_Sparadoxus | rna-NM_001181641.1_Sparadoxus | cds-NP_012327.1_Sparadoxus | 90.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |