Gene name: NTH1
Reference locus (S288C): YDR001C
Gene biotype: protein_coding
Description: Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; phosphorylated and activated by Cdc28p at the G1/S phase transition to coordinately regulate carbohydrate metabolism and the cell cycle; inhibited by Dcs1p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication; Belongs to the glycosyl hydrolase 37 family
Top 10 interactors (score): TPS1 (0.998); TPS2 (0.998); BMH1 (0.997); ATH1 (0.996); GLK1 (0.994); TSL1 (0.994); TPS3 (0.994); HSP104 (0.988); PGM2 (0.986); HXK1 (0.981); TPK1 (0.976); MSC1 (0.975); NTH2 (0.966); HSP78 (0.962); DCS1 (0.961); HSP26 (0.96); HXK2 (0.955); TPK2 (0.953); EMI2 (0.948); GPH1 (0.938)
Homologues (species, bitscore): TREH (Homo sapiens, 117.1); Treh (Mus musculus, 112.8); treh (Danio rerio, 144.1); treh (Xenopus tropicalis, 97.8); Treh (Drosophila melanogaster, 114.0); tre-2 (Caenorhabditis elegans, 115.5); TRE1 (Arabidopsis thaliana, 108.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:435469-437724:- | gene-YDR001C_AKU4011 | rna-NM_001180309.1_AKU4011 | cds-NP_010284.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:111428-113683:+ | gene-YDR001C_BG1 | rna-NM_001180309.1_BG1 | cds-NP_010284.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:456076-458331:- | gene-YDR001C_Bruggeman | rna-NM_001180309.1_Bruggeman | cds-NP_010284.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:448921-451176:- | gene-YDR001C_CAT1 | rna-NM_001180309.1_CAT1 | cds-NP_010284.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:432680-434935:- | gene-YDR001C_CBS1585 | rna-NM_001180309.1_CBS1585 | cds-NP_010284.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:449451-451706:- | gene-YDR001C_CBS436 | rna-NM_001180309.1_CBS436 | cds-NP_010284.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:429928-432183:- | gene-YDR001C_CBS6412 | rna-NM_001180309.1_CBS6412 | cds-NP_010284.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:451618-453873:- | gene-YDR001C_CBS6413 | rna-NM_001180309.1_CBS6413 | cds-NP_010284.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:449083-451338:- | gene-YDR001C_CENPK1137D | rna-NM_001180309.1_CENPK1137D | cds-NP_010284.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:444299-446554:- | gene-YDR001C_EthanolRed | rna-NM_001180309.1_EthanolRed | cds-NP_010284.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:450470-452725:- | gene-YDR001C_FaliES1 | rna-NM_001180309.1_FaliES1 | cds-NP_010284.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000442.1:19318-21573:+ | gene-YDR001C_JAY291 | rna-NM_001180309.1_JAY291 | cds-NP_010284.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:449947-452202:- | gene-YDR001C_MUCL30387 | rna-NM_001180309.1_MUCL30387 | cds-NP_010284.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:440409-442664:- | gene-YDR001C_MUCL30388 | rna-NM_001180309.1_MUCL30388 | cds-NP_010284.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:434049-436304:- | gene-YDR001C_MUCL39482 | rna-NM_001180309.1_MUCL39482 | cds-NP_010284.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:355482-357737:- | gene-YDR001C_MUCL42920 | rna-NM_001180309.1_MUCL42920 | cds-NP_010284.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:450143-452398:- | gene-YDR001C_NCIM3186 | rna-NM_001180309.1_NCIM3186 | cds-NP_010284.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:432971-435226:- | gene-YDR001C_NCYC1407 | rna-NM_001180309.1_NCYC1407 | cds-NP_010284.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:448602-450857:- | gene-YDR001C_PE2H3 | rna-NM_001180309.1_PE2H3 | cds-NP_010284.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:447891-450146:- | gene-YDR001C_PE2H4 | rna-NM_001180309.1_PE2H4 | cds-NP_010284.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:450220-452475:- | gene-YDR001C_S288C | rna-NM_001180309.1_S288C | cds-NP_010284.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000099.1:19497-21752:+ | gene-YDR001C_SA1 | rna-NM_001180309.1_SA1 | cds-NP_010284.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:449949-452204:- | gene-YDR001C_ThermosaccDry | rna-NM_001180309.1_ThermosaccDry | cds-NP_010284.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:454389-456644:- | gene-YDR001C_VR1 | rna-NM_001180309.1_VR1 | cds-NP_010284.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:447846-450101:- | gene-YDR001C_ZTW1 | rna-NM_001180309.1_ZTW1 | cds-NP_010284.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:452173-454428:- | gene-YDR001C_Sparadoxus | rna-NM_001180309.1_Sparadoxus | cds-NP_010284.1_Sparadoxus | 93.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |