Gene name: NTG1
Reference locus (S288C): YAL015C
Gene biotype: protein_coding
Description: Endonuclease III homolog 1; DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; required for maintaining mitochondrial genome integrity; NTG1 has a paralog, NTG2, that arose from the whole genome duplication; Belongs to the Nth/MutY family
Top 10 interactors (score): APN1 (0.996); APN2 (0.983); OGG1 (0.978); NTG2 (0.958); UNG1 (0.955); RAD14 (0.93); RAD27 (0.893); SRP54 (0.882); RAD9 (0.863); SEC65 (0.858); MRE11 (0.844); RAD1 (0.835); RAD2 (0.831); REV3 (0.83); RAD10 (0.809); URA3 (0.802); CDC9 (0.798); RAD52 (0.797); RRP6 (0.782); DUT1 (0.78)
Homologues (species, bitscore): NTHL1 (Homo sapiens, 179.5); Nthl1 (Mus musculus, 190.7); nthl1 (Danio rerio, 171.4); nthl1 (Xenopus tropicalis, 166.8); CG9272 (Drosophila melanogaster, 163.7); nth-1 (Caenorhabditis elegans, 157.5); ATNTH1 (Arabidopsis thaliana, 174.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005295.1:112016-113215:- | gene-YAL015C_AKU4011 | rna-NM_001178160.1_AKU4011 | cds-NP_009387.1_AKU4011 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000070.1:98966-100165:- | gene-YAL015C_BG1 | rna-NM_001178160.1_BG1 | cds-NP_009387.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005503.1:126888-128087:- | gene-YAL015C_Bruggeman | rna-NM_001178160.1_Bruggeman | cds-NP_009387.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005519.1:113226-114425:- | gene-YAL015C_CAT1 | rna-NM_001178160.1_CAT1 | cds-NP_009387.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005359.1:125028-126227:- | gene-YAL015C_CBS1585 | rna-NM_001178160.1_CBS1585 | cds-NP_009387.1_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005343.1:125306-126505:- | gene-YAL015C_CBS436 | rna-NM_001178160.1_CBS436 | cds-NP_009387.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:738122-739321:- | gene-YAL015C_CBS6412 | rna-NM_001178160.1_CBS6412 | cds-NP_009387.1_CBS6412 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005311.1:123298-124497:- | gene-YAL015C_CBS6413 | rna-NM_001178160.1_CBS6413 | cds-NP_009387.1_CBS6413 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001522.1:127063-128262:- | gene-YAL015C_CENPK1137D | rna-NM_001178160.1_CENPK1137D | cds-NP_009387.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005471.1:113437-114636:- | gene-YAL015C_EthanolRed | rna-NM_001178160.1_EthanolRed | cds-NP_009387.1_EthanolRed | 98.9 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005535.1:128064-129263:- | gene-YAL015C_FaliES1 | rna-NM_001178160.1_FaliES1 | cds-NP_009387.1_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000084.1:99334-100533:- | gene-YAL015C_JAY291 | rna-NM_001178160.1_JAY291 | cds-NP_009387.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005407.1:128042-129241:- | gene-YAL015C_MUCL30387 | rna-NM_001178160.1_MUCL30387 | cds-NP_009387.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005439.1:125288-126487:- | gene-YAL015C_MUCL30388 | rna-NM_001178160.1_MUCL30388 | cds-NP_009387.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005279.1:123810-125009:- | gene-YAL015C_MUCL39482 | rna-NM_001178160.1_MUCL39482 | cds-NP_009387.1_MUCL39482 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005423.1:126193-127392:- | gene-YAL015C_MUCL42920 | rna-NM_001178160.1_MUCL42920 | cds-NP_009387.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011810.1:126780-127979:- | gene-YAL015C_NCIM3186 | rna-NM_001178160.1_NCIM3186 | cds-NP_009387.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005263.1:111693-112892:- | gene-YAL015C_NCYC1407 | rna-NM_001178160.1_NCYC1407 | cds-NP_009387.1_NCYC1407 | 98.8 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994140.1:113622-114821:- | gene-YAL015C_PE2H3 | rna-NM_001178160.1_PE2H3 | cds-NP_009387.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999872.1:113341-114540:- | gene-YAL015C_PE2H4 | rna-NM_001178160.1_PE2H4 | cds-NP_009387.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001133.9:126903-128102:- | gene-YAL015C_S288C | rna-NM_001178160.1_S288C | cds-NP_009387.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000077.1:43826-45025:- | gene-YAL015C_SA1 | rna-NM_001178160.1_SA1 | cds-NP_009387.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005487.1:127556-128755:- | gene-YAL015C_ThermosaccDry | rna-NM_001178160.1_ThermosaccDry | cds-NP_009387.1_ThermosaccDry | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005455.1:128864-130063:- | gene-YAL015C_VR1 | rna-NM_001178160.1_VR1 | cds-NP_009387.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000002.1:99383-100582:- | gene-YAL015C_ZTW1 | rna-NM_001178160.1_ZTW1 | cds-NP_009387.1_ZTW1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047487.1:116887-118086:- | gene-YAL015C_Sparadoxus | rna-NM_001178160.1_Sparadoxus | cds-NP_009387.1_Sparadoxus | 89.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |