Gene name: NSG1
Reference locus (S288C): YHR133C
Gene biotype: protein_coding
Description: Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; forms foci at the nuclear periphery upon DNA replication stress; relocalizes to the cytosol in response to hypoxia; homolog of mammalian INSIG proteins; NSG1 has a paralog, NSG2, that arose from the whole genome duplication
Top 10 interactors (score): HMG2 (0.858); ASI1 (0.75); ASI3 (0.749); VTC1 (0.695); ERG11 (0.692); HEH2 (0.659); POM33 (0.651); ASI2 (0.651); VCX1 (0.618); IRC23 (0.614); VTC4 (0.575); HRD1 (0.574); SPC2 (0.566); MATALPHA2 (0.561); SSM4 (0.557); HMLALPHA2 (0.527); POM34 (0.526); PNG1 (0.523); ERG24 (0.499); CBF2 (0.499)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:357654-358529:- | gene-YHR133C_AKU4011 | rna-NM_001179263.1_AKU4011 | cds-NP_012001.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000141.1:159325-160200:+ | gene-YHR133C_BG1 | rna-NM_001179263.1_BG1 | cds-NP_012001.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:364871-365746:- | gene-YHR133C_Bruggeman | rna-NM_001179263.1_Bruggeman | cds-NP_012001.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005526.1:360069-360944:- | gene-YHR133C_CAT1 | rna-NM_001179263.1_CAT1 | cds-NP_012001.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:356676-357551:- | gene-YHR133C_CBS1585 | rna-NM_001179263.1_CBS1585 | cds-NP_012001.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005350.1:354029-354904:- | gene-YHR133C_CBS436 | rna-NM_001179263.1_CBS436 | cds-NP_012001.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005334.1:358117-358992:- | gene-YHR133C_CBS6412 | rna-NM_001179263.1_CBS6412 | cds-NP_012001.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:357706-358581:- | gene-YHR133C_CBS6413 | rna-NM_001179263.1_CBS6413 | cds-NP_012001.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:363896-364771:- | gene-YHR133C_CENPK1137D | rna-NM_001179263.1_CENPK1137D | cds-NP_012001.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:416565-417440:- | gene-YHR133C_EthanolRed | rna-NM_001179263.1_EthanolRed | cds-NP_012001.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:358053-358928:- | gene-YHR133C_FaliES1 | rna-NM_001179263.1_FaliES1 | cds-NP_012001.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000275.1:181-1056:- | gene-YHR133C_JAY291 | rna-NM_001179263.1_JAY291 | cds-NP_012001.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:364601-365476:- | gene-YHR133C_MUCL30387 | rna-NM_001179263.1_MUCL30387 | cds-NP_012001.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005446.1:364866-365741:- | gene-YHR133C_MUCL30388 | rna-NM_001179263.1_MUCL30388 | cds-NP_012001.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:357020-357895:- | gene-YHR133C_MUCL39482 | rna-NM_001179263.1_MUCL39482 | cds-NP_012001.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005430.1:363233-364108:- | gene-YHR133C_MUCL42920 | rna-NM_001179263.1_MUCL42920 | cds-NP_012001.1_MUCL42920 | 98.8 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:370604-371479:- | gene-YHR133C_NCIM3186 | rna-NM_001179263.1_NCIM3186 | cds-NP_012001.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005270.1:359228-360103:- | gene-YHR133C_NCYC1407 | rna-NM_001179263.1_NCYC1407 | cds-NP_012001.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994147.1:358669-359544:- | gene-YHR133C_PE2H3 | rna-NM_001179263.1_PE2H3 | cds-NP_012001.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:366096-366971:- | gene-YHR133C_PE2H4 | rna-NM_001179263.1_PE2H4 | cds-NP_012001.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:370722-371597:- | gene-YHR133C_S288C | rna-NM_001179263.1_S288C | cds-NP_012001.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000103.1:17800-18675:+ | gene-YHR133C_SA1 | rna-NM_001179263.1_SA1 | cds-NP_012001.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:359136-360011:- | gene-YHR133C_ThermosaccDry | rna-NM_001179263.1_ThermosaccDry | cds-NP_012001.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:367579-368454:- | gene-YHR133C_VR1 | rna-NM_001179263.1_VR1 | cds-NP_012001.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000017.1:350134-351009:- | gene-YHR133C_ZTW1 | rna-NM_001179263.1_ZTW1 | cds-NP_012001.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047494.1:356584-357459:- | gene-YHR133C_Sparadoxus | rna-NM_001179263.1_Sparadoxus | cds-NP_012001.1_Sparadoxus | 89.2 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |