Gene name: NPR2
Reference locus (S288C): YEL062W
Gene biotype: protein_coding
Description: Nitrogen permease regulator 2; Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of the SEA complex, a coatomer-related complex that associates dynamically with the vacuole; Npr2p may have a structural or regulatory role, supporting Iml1p function as a GAP for the Rag family GTPase Gtr1p, and resulting in inhibition of TORC1 signaling in response to amino acid deprivation; SEACIT is required for non-nitrogen-starvation-induced autophagy; homolog of human tumor suppressor NPRL2
Top 10 interactors (score): SEA4 (0.999); GTR1 (0.999); MTC5 (0.999); IML1 (0.999); RTC1 (0.999); NPR3 (0.998); SEH1 (0.995); SEC13 (0.994); GTR2 (0.985); LST7 (0.942); TOR1 (0.798); KOG1 (0.763); RHB1 (0.761); PPM1 (0.754); SCH9 (0.743); TOR2 (0.731); LST8 (0.717); MEH1 (0.711); SLM4 (0.697); AVT2 (0.697)
Homologues (species, bitscore): NPRL2 (Homo sapiens, 130.6); Nprl2 (Mus musculus, 129.4); nprl2 (Danio rerio, 125.9); nprl2 (Xenopus tropicalis, 126.3); Nprl2 (Drosophila melanogaster, 110.5); nprl-2 (Caenorhabditis elegans, 87.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:28815-30662:+ | gene-YEL062W_AKU4011 | rna-NM_001178877.3_AKU4011 | cds-NP_010852.4_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000075.1:49851-51698:- | gene-YEL062W_BG1 | rna-NM_001178877.3_BG1 | cds-NP_010852.4_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:32326-34173:+ | gene-YEL062W_Bruggeman | rna-NM_001178877.3_Bruggeman | cds-NP_010852.4_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:30758-32605:+ | gene-YEL062W_CAT1 | rna-NM_001178877.3_CAT1 | cds-NP_010852.4_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:28760-30607:+ | gene-YEL062W_CBS1585 | rna-NM_001178877.3_CBS1585 | cds-NP_010852.4_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:29816-31663:+ | gene-YEL062W_CBS436 | rna-NM_001178877.3_CBS436 | cds-NP_010852.4_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:29012-30859:+ | gene-YEL062W_CBS6412 | rna-NM_001178877.3_CBS6412 | cds-NP_010852.4_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:33656-35503:+ | gene-YEL062W_CBS6413 | rna-NM_001178877.3_CBS6413 | cds-NP_010852.4_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:32251-34098:+ | gene-YEL062W_CENPK1137D | rna-NM_001178877.3_CENPK1137D | cds-NP_010852.4_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:28575-30422:+ | gene-YEL062W_EthanolRed | rna-NM_001178877.3_EthanolRed | cds-NP_010852.4_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:28838-30685:+ | gene-YEL062W_FaliES1 | rna-NM_001178877.3_FaliES1 | cds-NP_010852.4_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000427.1:27385-29232:- | gene-YEL062W_JAY291 | rna-NM_001178877.3_JAY291 | cds-NP_010852.4_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:32767-34614:+ | gene-YEL062W_MUCL30387 | rna-NM_001178877.3_MUCL30387 | cds-NP_010852.4_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:28877-30724:+ | gene-YEL062W_MUCL30388 | rna-NM_001178877.3_MUCL30388 | cds-NP_010852.4_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:28127-29974:+ | gene-YEL062W_MUCL39482 | rna-NM_001178877.3_MUCL39482 | cds-NP_010852.4_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:32759-34606:+ | gene-YEL062W_MUCL42920 | rna-NM_001178877.3_MUCL42920 | cds-NP_010852.4_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:34406-36253:+ | gene-YEL062W_NCIM3186 | rna-NM_001178877.3_NCIM3186 | cds-NP_010852.4_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:33226-35073:+ | gene-YEL062W_NCYC1407 | rna-NM_001178877.3_NCYC1407 | cds-NP_010852.4_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:37221-39068:+ | gene-YEL062W_PE2H3 | rna-NM_001178877.3_PE2H3 | cds-NP_010852.4_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:33146-34993:+ | gene-YEL062W_PE2H4 | rna-NM_001178877.3_PE2H4 | cds-NP_010852.4_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:34407-36254:+ | gene-YEL062W_S288C | rna-NM_001178877.3_S288C | cds-NP_010852.4_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000053.1:50650-52497:- | gene-YEL062W_SA1 | rna-NM_001178877.3_SA1 | cds-NP_010852.4_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:29238-31085:+ | gene-YEL062W_ThermosaccDry | rna-NM_001178877.3_ThermosaccDry | cds-NP_010852.4_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:28441-30288:+ | gene-YEL062W_VR1 | rna-NM_001178877.3_VR1 | cds-NP_010852.4_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:28176-30023:+ | gene-YEL062W_ZTW1 | rna-NM_001178877.3_ZTW1 | cds-NP_010852.4_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:32579-34426:+ | gene-YEL062W_Sparadoxus | rna-NM_001178877.3_Sparadoxus | cds-NP_010852.4_Sparadoxus | 88.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |