Gene name: NPR1
Reference locus (S288C): YNL183C
Gene biotype: protein_coding
Description: Nitrogen permease reactivator protein; Protein kinase; stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex; NPR1 has a paralog, PRR2, that arose from the whole genome duplication
Top 10 interactors (score): TOR2 (0.895); BUL1 (0.89); PAR32 (0.878); MEC1 (0.875); TOR1 (0.873); GAP1 (0.865); BUL2 (0.844); ALY2 (0.832); RSP5 (0.829); MEP1 (0.822); TAT2 (0.811); TAP42 (0.803); MEP2 (0.797); ALY1 (0.796); GLN3 (0.795); ORM1 (0.786); GGA1 (0.784); MEP3 (0.784); LST4 (0.78); SIT4 (0.771)
Homologues (species, bitscore): MARK2 (Homo sapiens, 115.2); Mark2 (Mus musculus, 115.2); mark3 (Danio rerio, 115.2); mark2 (Xenopus tropicalis, 115.5); KP78a (Drosophila melanogaster, 109.8); par-1 (Caenorhabditis elegans, 108.6); AT1G67580 (Arabidopsis thaliana, 106.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:286880-289252:- | gene-YNL183C_AKU4011 | rna-NM_001183021.1_AKU4011 | cds-NP_014216.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:190856-193228:- | gene-YNL183C_BG1 | rna-NM_001183021.1_BG1 | cds-NP_014216.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:296913-299285:- | gene-YNL183C_Bruggeman | rna-NM_001183021.1_Bruggeman | cds-NP_014216.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:339207-341579:- | gene-YNL183C_CAT1 | rna-NM_001183021.1_CAT1 | cds-NP_014216.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:287523-289895:- | gene-YNL183C_CBS1585 | rna-NM_001183021.1_CBS1585 | cds-NP_014216.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:355833-358205:- | gene-YNL183C_CBS436 | rna-NM_001183021.1_CBS436 | cds-NP_014216.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:282937-285309:- | gene-YNL183C_CBS6412 | rna-NM_001183021.1_CBS6412 | cds-NP_014216.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:283956-286328:- | gene-YNL183C_CBS6413 | rna-NM_001183021.1_CBS6413 | cds-NP_014216.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:286965-289337:- | gene-YNL183C_CENPK1137D | rna-NM_001183021.1_CENPK1137D | cds-NP_014216.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:283855-286227:- | gene-YNL183C_EthanolRed | rna-NM_001183021.1_EthanolRed | cds-NP_014216.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:279768-282140:- | gene-YNL183C_FaliES1 | rna-NM_001183021.1_FaliES1 | cds-NP_014216.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000260.1:36382-38754:+ | gene-YNL183C_JAY291 | rna-NM_001183021.1_JAY291 | cds-NP_014216.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:292728-295100:- | gene-YNL183C_MUCL30387 | rna-NM_001183021.1_MUCL30387 | cds-NP_014216.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:327046-329418:- | gene-YNL183C_MUCL30388 | rna-NM_001183021.1_MUCL30388 | cds-NP_014216.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:284762-287134:- | gene-YNL183C_MUCL39482 | rna-NM_001183021.1_MUCL39482 | cds-NP_014216.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:287152-289524:- | gene-YNL183C_MUCL42920 | rna-NM_001183021.1_MUCL42920 | cds-NP_014216.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:293106-295478:- | gene-YNL183C_NCIM3186 | rna-NM_001183021.1_NCIM3186 | cds-NP_014216.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:286856-289228:- | gene-YNL183C_NCYC1407 | rna-NM_001183021.1_NCYC1407 | cds-NP_014216.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:283800-286172:- | gene-YNL183C_PE2H3 | rna-NM_001183021.1_PE2H3 | cds-NP_014216.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:283188-285560:- | gene-YNL183C_PE2H4 | rna-NM_001183021.1_PE2H4 | cds-NP_014216.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:293137-295509:- | gene-YNL183C_S288C | rna-NM_001183021.1_S288C | cds-NP_014216.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000018.1:118104-120476:+ | gene-YNL183C_SA1 | rna-NM_001183021.1_SA1 | cds-NP_014216.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:280625-282997:- | gene-YNL183C_ThermosaccDry | rna-NM_001183021.1_ThermosaccDry | cds-NP_014216.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:299124-301496:- | gene-YNL183C_VR1 | rna-NM_001183021.1_VR1 | cds-NP_014216.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:190452-192824:- | gene-YNL183C_ZTW1 | rna-NM_001183021.1_ZTW1 | cds-NP_014216.1_ZTW1 | 99.4 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:291155-293527:- | gene-YNL183C_Sparadoxus | rna-NM_001183021.1_Sparadoxus | cds-NP_014216.1_Sparadoxus | 91.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |