Gene name: NPP2
Reference locus (S288C): YEL016C
Gene biotype: protein_coding
Description: Ectonucleotide pyrophosphatase/phosphodiesterase 2; Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; NPP2 has a paralog, NPP1, that arose from the whole genome duplication; npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to single mutants
Top 10 interactors (score): SLO1 (0.891); YEL014C (0.87); IDI1 (0.624); PHO8 (0.618); MXR1 (0.616); GDA1 (0.61); CYC2 (0.584); VMA3 (0.54); PAN5 (0.534); LAA1 (0.53); BPH1 (0.523); RHO1 (0.517); NUP85 (0.516); YBR241C (0.515); CCC2 (0.514); APL3 (0.51); VPS73 (0.509); SEC26 (0.508); DYN2 (0.507); STV1 (0.504)
Homologues (species, bitscore): ENPP3 (Homo sapiens, 139.4); Enpp3 (Mus musculus, 139.4); enpp1 (Danio rerio, 153.3); enpp3 (Xenopus tropicalis, 117.9); C27A7.3 (Caenorhabditis elegans, 104.0); AT4G29680 (Arabidopsis thaliana, 144.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:118765-120245:- | gene-YEL016C_AKU4011 | rna-NM_001178831.1_AKU4011 | cds-NP_010900.1_AKU4011 | 98.9 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:305719-307200:+ | gene-YEL016C_BG1 | rna-NM_001178831.1_BG1 | cds-NP_010900.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:125291-126772:- | gene-YEL016C_Bruggeman | rna-NM_001178831.1_Bruggeman | cds-NP_010900.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:120943-122424:- | gene-YEL016C_CAT1 | rna-NM_001178831.1_CAT1 | cds-NP_010900.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:118707-120187:- | gene-YEL016C_CBS1585 | rna-NM_001178831.1_CBS1585 | cds-NP_010900.1_CBS1585 | 98.9 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:120342-121823:- | gene-YEL016C_CBS436 | rna-NM_001178831.1_CBS436 | cds-NP_010900.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:118985-120465:- | gene-YEL016C_CBS6412 | rna-NM_001178831.1_CBS6412 | cds-NP_010900.1_CBS6412 | 98.7 | 99.9 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:123592-125073:- | gene-YEL016C_CBS6413 | rna-NM_001178831.1_CBS6413 | cds-NP_010900.1_CBS6413 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:122594-124075:- | gene-YEL016C_CENPK1137D | rna-NM_001178831.1_CENPK1137D | cds-NP_010900.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:119086-120567:- | gene-YEL016C_EthanolRed | rna-NM_001178831.1_EthanolRed | cds-NP_010900.1_EthanolRed | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:119345-120826:- | gene-YEL016C_FaliES1 | rna-NM_001178831.1_FaliES1 | cds-NP_010900.1_FaliES1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000398.1:38234-39715:- | gene-YEL016C_JAY291 | rna-NM_001178831.1_JAY291 | cds-NP_010900.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:123011-124492:- | gene-YEL016C_MUCL30387 | rna-NM_001178831.1_MUCL30387 | cds-NP_010900.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:118984-120464:- | gene-YEL016C_MUCL30388 | rna-NM_001178831.1_MUCL30388 | cds-NP_010900.1_MUCL30388 | 98.9 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:118069-119550:- | gene-YEL016C_MUCL39482 | rna-NM_001178831.1_MUCL39482 | cds-NP_010900.1_MUCL39482 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:122699-124180:- | gene-YEL016C_MUCL42920 | rna-NM_001178831.1_MUCL42920 | cds-NP_010900.1_MUCL42920 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:124736-126217:- | gene-YEL016C_NCIM3186 | rna-NM_001178831.1_NCIM3186 | cds-NP_010900.1_NCIM3186 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:123174-124655:- | gene-YEL016C_NCYC1407 | rna-NM_001178831.1_NCYC1407 | cds-NP_010900.1_NCYC1407 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:127201-128682:- | gene-YEL016C_PE2H3 | rna-NM_001178831.1_PE2H3 | cds-NP_010900.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:123116-124597:- | gene-YEL016C_PE2H4 | rna-NM_001178831.1_PE2H4 | cds-NP_010900.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:124737-126218:- | gene-YEL016C_S288C | rna-NM_001178831.1_S288C | cds-NP_010900.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000020.1:117008-118489:+ | gene-YEL016C_SA1 | rna-NM_001178831.1_SA1 | cds-NP_010900.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:119750-121231:- | gene-YEL016C_ThermosaccDry | rna-NM_001178831.1_ThermosaccDry | cds-NP_010900.1_ThermosaccDry | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:119292-120773:- | gene-YEL016C_VR1 | rna-NM_001178831.1_VR1 | cds-NP_010900.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:118112-119592:- | gene-YEL016C_ZTW1 | rna-NM_001178831.1_ZTW1 | cds-NP_010900.1_ZTW1 | 99.1 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:121527-123008:- | gene-YEL016C_Sparadoxus | rna-NM_001178831.1_Sparadoxus | cds-NP_010900.1_Sparadoxus | 88.4 | 99.9 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |