Gene name: NPP1
Reference locus (S288C): YCR026C
Gene biotype: protein_coding
Description: Ectonucleotide pyrophosphatase/phosphodiesterase 1; Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; NPP1 has a paralog, NPP2, that arose from the whole genome duplication, and an npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants
Top 10 interactors (score): YCR25C (0.896); IRC18 (0.817); SHE10 (0.813); OSW7 (0.813); OSW2 (0.749); RRT8 (0.746); LOH1 (0.746); ROG1 (0.738); YJR124C (0.717); QDR3 (0.71); SLM5 (0.694); YJR015W (0.693); RRT12 (0.684); PAN5 (0.681); OSW5 (0.68); YLR046C (0.678); PRM4 (0.661); MIP6 (0.66); EMG1 (0.657); IDI1 (0.65)
Homologues (species, bitscore): ENPP3 (Homo sapiens, 146.4); Enpp3 (Mus musculus, 148.7); enpp1 (Danio rerio, 159.5); enpp2 (Xenopus tropicalis, 134.4); C27A7.3 (Caenorhabditis elegans, 127.1); AT4G29680 (Arabidopsis thaliana, 153.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005297.1:158597-160825:- | gene-YCR026C_AKU4011 | rna-NM_001178741.1_AKU4011 | cds-NP_009955.2_AKU4011 | 99.1 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000067.1:12751-14979:- | gene-YCR026C_BG1 | rna-NM_001178741.1_BG1 | cds-NP_009955.2_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005505.1:153918-156146:- | gene-YCR026C_Bruggeman | rna-NM_001178741.1_Bruggeman | cds-NP_009955.2_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005521.1:165487-167715:- | gene-YCR026C_CAT1 | rna-NM_001178741.1_CAT1 | cds-NP_009955.2_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005361.1:153358-155586:- | gene-YCR026C_CBS1585 | rna-NM_001178741.1_CBS1585 | cds-NP_009955.2_CBS1585 | 99.2 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005345.1:164496-166724:- | gene-YCR026C_CBS436 | rna-NM_001178741.1_CBS436 | cds-NP_009955.2_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005329.1:147211-149439:- | gene-YCR026C_CBS6412 | rna-NM_001178741.1_CBS6412 | cds-NP_009955.2_CBS6412 | 99.2 | 99.8 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005313.1:159535-161763:- | gene-YCR026C_CBS6413 | rna-NM_001178741.1_CBS6413 | cds-NP_009955.2_CBS6413 | 99.2 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001524.1:163593-165821:- | gene-YCR026C_CENPK1137D | rna-NM_001178741.1_CENPK1137D | cds-NP_009955.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005473.1:156607-158841:- | gene-YCR026C_EthanolRed | rna-NM_001178741.1_EthanolRed | cds-NP_009955.2_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005537.1:159468-161702:- | gene-YCR026C_FaliES1 | rna-NM_001178741.1_FaliES1 | cds-NP_009955.2_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000371.1:2081-4309:+ | gene-YCR026C_JAY291 | rna-NM_001178741.1_JAY291 | cds-NP_009955.2_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005409.1:151096-153324:- | gene-YCR026C_MUCL30387 | rna-NM_001178741.1_MUCL30387 | cds-NP_009955.2_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005441.1:151362-153590:- | gene-YCR026C_MUCL30388 | rna-NM_001178741.1_MUCL30388 | cds-NP_009955.2_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005281.1:159682-161910:- | gene-YCR026C_MUCL39482 | rna-NM_001178741.1_MUCL39482 | cds-NP_009955.2_MUCL39482 | 99.2 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005425.1:156074-158302:- | gene-YCR026C_MUCL42920 | rna-NM_001178741.1_MUCL42920 | cds-NP_009955.2_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011812.1:163743-165971:- | gene-YCR026C_NCIM3186 | rna-NM_001178741.1_NCIM3186 | cds-NP_009955.2_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005265.1:161446-163674:- | gene-YCR026C_NCYC1407 | rna-NM_001178741.1_NCYC1407 | cds-NP_009955.2_NCYC1407 | 99.2 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994142.1:170150-172378:- | gene-YCR026C_PE2H3 | rna-NM_001178741.1_PE2H3 | cds-NP_009955.2_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999874.1:164771-166999:- | gene-YCR026C_PE2H4 | rna-NM_001178741.1_PE2H4 | cds-NP_009955.2_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001135.5:164111-166339:- | gene-YCR026C_S288C | rna-NM_001178741.1_S288C | cds-NP_009955.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000083.1:12640-14868:- | gene-YCR026C_SA1 | rna-NM_001178741.1_SA1 | cds-NP_009955.2_SA1 | 99.3 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005489.1:159539-161773:- | gene-YCR026C_ThermosaccDry | rna-NM_001178741.1_ThermosaccDry | cds-NP_009955.2_ThermosaccDry | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005457.1:170300-172528:- | gene-YCR026C_VR1 | rna-NM_001178741.1_VR1 | cds-NP_009955.2_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000004.1:158470-160701:- | gene-YCR026C_ZTW1 | rna-NM_001178741.1_ZTW1 | cds-NP_009955.2_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047489.1:191709-193928:- | gene-YCR026C_Sparadoxus | rna-NM_001178741.1_Sparadoxus | cds-NP_009955.2_Sparadoxus | 87.3 | 99.2 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |