Gene name: NPL4
Reference locus (S288C): YBR170C
Gene biotype: protein_coding
Description: Nuclear protein localization protein 4; Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)
Top 10 interactors (score): UFD1 (0.999); UBX2 (0.999); HRD1 (0.999); SSM4 (0.999); CDC48 (0.999); HRD3 (0.997); DER1 (0.997); VMS1 (0.994); UBC7 (0.992); UFD2 (0.991); RQC1 (0.99); CUE1 (0.99); DOA1 (0.989); RQC2 (0.988); RKR1 (0.983); AFG2 (0.982); USA1 (0.98); YOS9 (0.973); UBX5 (0.971); UBI4 (0.971)
Homologues (species, bitscore): NPLOC4 (Homo sapiens, 338.6); Nploc4 (Mus musculus, 308.5); nploc4 (Danio rerio, 324.7); nploc4 (Xenopus tropicalis, 322.8); Npl4 (Drosophila melanogaster, 322.8); npl-4.2 (Caenorhabditis elegans, 314.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:559216-560958:- | gene-YBR170C_AKU4011 | rna-NM_001178518.1_AKU4011 | cds-NP_009729.1_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:549723-551465:- | gene-YBR170C_BG1 | rna-NM_001178518.1_BG1 | cds-NP_009729.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:562237-563979:- | gene-YBR170C_Bruggeman | rna-NM_001178518.1_Bruggeman | cds-NP_009729.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:456350-458092:- | gene-YBR170C_CAT1 | rna-NM_001178518.1_CAT1 | cds-NP_009729.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:550997-552739:- | gene-YBR170C_CBS1585 | rna-NM_001178518.1_CBS1585 | cds-NP_009729.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:559077-560819:- | gene-YBR170C_CBS436 | rna-NM_001178518.1_CBS436 | cds-NP_009729.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:648482-650224:- | gene-YBR170C_CBS6412 | rna-NM_001178518.1_CBS6412 | cds-NP_009729.1_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:556553-558295:- | gene-YBR170C_CBS6413 | rna-NM_001178518.1_CBS6413 | cds-NP_009729.1_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:570141-571883:- | gene-YBR170C_CENPK1137D | rna-NM_001178518.1_CENPK1137D | cds-NP_009729.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:685058-686800:- | gene-YBR170C_EthanolRed | rna-NM_001178518.1_EthanolRed | cds-NP_009729.1_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:575290-577032:- | gene-YBR170C_FaliES1 | rna-NM_001178518.1_FaliES1 | cds-NP_009729.1_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000310.1:15121-16863:- | gene-YBR170C_JAY291 | rna-NM_001178518.1_JAY291 | cds-NP_009729.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:563890-565632:- | gene-YBR170C_MUCL30387 | rna-NM_001178518.1_MUCL30387 | cds-NP_009729.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:563176-564918:- | gene-YBR170C_MUCL30388 | rna-NM_001178518.1_MUCL30388 | cds-NP_009729.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:549370-551112:- | gene-YBR170C_MUCL39482 | rna-NM_001178518.1_MUCL39482 | cds-NP_009729.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:559292-561034:- | gene-YBR170C_MUCL42920 | rna-NM_001178518.1_MUCL42920 | cds-NP_009729.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:576141-577883:- | gene-YBR170C_NCIM3186 | rna-NM_001178518.1_NCIM3186 | cds-NP_009729.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:551939-553681:- | gene-YBR170C_NCYC1407 | rna-NM_001178518.1_NCYC1407 | cds-NP_009729.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:564595-566337:- | gene-YBR170C_PE2H3 | rna-NM_001178518.1_PE2H3 | cds-NP_009729.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:562271-564013:- | gene-YBR170C_PE2H4 | rna-NM_001178518.1_PE2H4 | cds-NP_009729.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:576344-578086:- | gene-YBR170C_S288C | rna-NM_001178518.1_S288C | cds-NP_009729.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000032.1:97587-99329:- | gene-YBR170C_SA1 | rna-NM_001178518.1_SA1 | cds-NP_009729.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:574300-576042:- | gene-YBR170C_ThermosaccDry | rna-NM_001178518.1_ThermosaccDry | cds-NP_009729.1_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:555746-557488:- | gene-YBR170C_VR1 | rna-NM_001178518.1_VR1 | cds-NP_009729.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:549417-551159:- | gene-YBR170C_ZTW1 | rna-NM_001178518.1_ZTW1 | cds-NP_009729.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:586782-588524:- | gene-YBR170C_Sparadoxus | rna-NM_001178518.1_Sparadoxus | cds-NP_009729.1_Sparadoxus | 89.7 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |