Gene name: NPL3
Reference locus (S288C): YDR432W
Gene biotype: protein_coding
Description: Transcription initiation factor tfiid subunit 15; Nucleolar protein 3; RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; represses translation initiation by binding eIF4G; required for pre-mRNA splicing; interacts with E3 ubiquitin ligase Bre1p, linking histone ubiquitination to mRNA processing; may have role in telomere maintenance; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in cytoplasm; protein abundance increases in response to DNA replication stress
Top 10 interactors (score): GBP2 (0.999); MTR10 (0.999); SKY1 (0.999); HMT1 (0.988); MEX67 (0.985); CBC2 (0.984); NAB2 (0.983); CEF1 (0.983); YRA1 (0.981); HRP1 (0.976); SNP1 (0.968); STO1 (0.968); RPS3 (0.965); MUD2 (0.956); MSL5 (0.933); PUB1 (0.923); NAM8 (0.923); SUB2 (0.919); GAR1 (0.917); TIF4631 (0.905)
Homologues (species, bitscore): TAF15 (Homo sapiens, 125.6); Taf15 (Mus musculus, 122.9); ncl (Danio rerio, 98.2); srsf6 (Xenopus tropicalis, 85.5); sqd (Drosophila melanogaster, 99.4); fust-1 (Caenorhabditis elegans, 86.3); AT5G40490 (Arabidopsis thaliana, 113.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:1269051-1270295:+ | gene-YDR432W_AKU4011 | rna-NM_001180740.3_AKU4011 | cds-NP_010720.3_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000039.1:147390-148634:+ | gene-YDR432W_BG1 | rna-NM_001180740.3_BG1 | cds-NP_010720.3_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1299438-1300682:+ | gene-YDR432W_Bruggeman | rna-NM_001180740.3_Bruggeman | cds-NP_010720.3_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1277632-1278876:+ | gene-YDR432W_CAT1 | rna-NM_001180740.3_CAT1 | cds-NP_010720.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1263380-1264603:+ | gene-YDR432W_CBS1585 | rna-NM_001180740.3_CBS1585 | cds-NP_010720.3_CBS1585 | 98.2 | 98.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1282712-1283956:+ | gene-YDR432W_CBS436 | rna-NM_001180740.3_CBS436 | cds-NP_010720.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1259346-1260590:+ | gene-YDR432W_CBS6412 | rna-NM_001180740.3_CBS6412 | cds-NP_010720.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1281495-1282739:+ | gene-YDR432W_CBS6413 | rna-NM_001180740.3_CBS6413 | cds-NP_010720.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1327461-1328705:+ | gene-YDR432W_CENPK1137D | rna-NM_001180740.3_CENPK1137D | cds-NP_010720.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1272628-1273872:+ | gene-YDR432W_EthanolRed | rna-NM_001180740.3_EthanolRed | cds-NP_010720.3_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1275935-1277179:+ | gene-YDR432W_FaliES1 | rna-NM_001180740.3_FaliES1 | cds-NP_010720.3_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000263.1:20213-21442:+ | gene-YDR432W_JAY291 | rna-NM_001180740.3_JAY291 | cds-NP_010720.3_JAY291 | 98.7 | 98.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1283080-1284324:+ | gene-YDR432W_MUCL30387 | rna-NM_001180740.3_MUCL30387 | cds-NP_010720.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1265016-1266260:+ | gene-YDR432W_MUCL30388 | rna-NM_001180740.3_MUCL30388 | cds-NP_010720.3_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:1254872-1256095:+ | gene-YDR432W_MUCL39482 | rna-NM_001180740.3_MUCL39482 | cds-NP_010720.3_MUCL39482 | 98.2 | 98.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1197272-1198516:+ | gene-YDR432W_MUCL42920 | rna-NM_001180740.3_MUCL42920 | cds-NP_010720.3_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1328706-1329950:+ | gene-YDR432W_NCIM3186 | rna-NM_001180740.3_NCIM3186 | cds-NP_010720.3_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1268636-1269880:+ | gene-YDR432W_NCYC1407 | rna-NM_001180740.3_NCYC1407 | cds-NP_010720.3_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1279457-1280686:+ | gene-YDR432W_PE2H3 | rna-NM_001180740.3_PE2H3 | cds-NP_010720.3_PE2H3 | 98.7 | 98.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1285025-1286254:+ | gene-YDR432W_PE2H4 | rna-NM_001180740.3_PE2H4 | cds-NP_010720.3_PE2H4 | 98.7 | 98.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1328783-1330027:+ | gene-YDR432W_S288C | rna-NM_001180740.3_S288C | cds-NP_010720.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000082.1:27190-28434:- | gene-YDR432W_SA1 | rna-NM_001180740.3_SA1 | cds-NP_010720.3_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1280197-1281441:+ | gene-YDR432W_ThermosaccDry | rna-NM_001180740.3_ThermosaccDry | cds-NP_010720.3_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:1295419-1296663:+ | gene-YDR432W_VR1 | rna-NM_001180740.3_VR1 | cds-NP_010720.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:322839-324083:+ | gene-YDR432W_ZTW1 | rna-NM_001180740.3_ZTW1 | cds-NP_010720.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1276588-1277844:+ | gene-YDR432W_Sparadoxus | rna-NM_001180740.3_Sparadoxus | cds-NP_010720.3_Sparadoxus | 91.2 | 99.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |