Gene name: NPC2
Reference locus (S288C): YDL046W
Gene biotype: protein_coding
Description: Phosphatidylglycerol/phosphatidylinositol transfer protein; Sterol transport protein and functional homolog of human NPC2/He1; human NPC2 is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes; yeast NPC2 can complement mutations in human NPC2; Belongs to the NPC2 family
Top 10 interactors (score): NCR1 (0.928); AUS1 (0.813); LAM6 (0.813); PDH1 (0.721); RCH1 (0.671); TOM71 (0.667); IDI1 (0.582); ERG9 (0.579); UPC2 (0.563); YKR051W (0.535); ERG10 (0.527); ERG26 (0.512); CYB5 (0.504); ECM22 (0.499); POT1 (0.485); ARE2 (0.474); VPS30 (0.474); PKR1 (0.45); SCM4 (0.45)
Homologues (species, bitscore): AT5G06480 (Arabidopsis thaliana, 54.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:355859-356380:+ | gene-YDL046W_AKU4011 | rna-NM_001180105.1_AKU4011 | cds-NP_010237.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:193324-193845:- | gene-YDL046W_BG1 | rna-NM_001180105.1_BG1 | cds-NP_010237.1_BG1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:373621-374142:+ | gene-YDL046W_Bruggeman | rna-NM_001180105.1_Bruggeman | cds-NP_010237.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:370561-371082:+ | gene-YDL046W_CAT1 | rna-NM_001180105.1_CAT1 | cds-NP_010237.1_CAT1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:354109-354630:+ | gene-YDL046W_CBS1585 | rna-NM_001180105.1_CBS1585 | cds-NP_010237.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:370781-371302:+ | gene-YDL046W_CBS436 | rna-NM_001180105.1_CBS436 | cds-NP_010237.1_CBS436 | 98.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:351816-352337:+ | gene-YDL046W_CBS6412 | rna-NM_001180105.1_CBS6412 | cds-NP_010237.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:372148-372669:+ | gene-YDL046W_CBS6413 | rna-NM_001180105.1_CBS6413 | cds-NP_010237.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:370100-370621:+ | gene-YDL046W_CENPK1137D | rna-NM_001180105.1_CENPK1137D | cds-NP_010237.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:366642-367163:+ | gene-YDL046W_EthanolRed | rna-NM_001180105.1_EthanolRed | cds-NP_010237.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:372870-373391:+ | gene-YDL046W_FaliES1 | rna-NM_001180105.1_FaliES1 | cds-NP_010237.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000097.1:12393-12914:- | gene-YDL046W_JAY291 | rna-NM_001180105.1_JAY291 | cds-NP_010237.1_JAY291 | 98.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:371006-371527:+ | gene-YDL046W_MUCL30387 | rna-NM_001180105.1_MUCL30387 | cds-NP_010237.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:362124-362645:+ | gene-YDL046W_MUCL30388 | rna-NM_001180105.1_MUCL30388 | cds-NP_010237.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:355313-355834:+ | gene-YDL046W_MUCL39482 | rna-NM_001180105.1_MUCL39482 | cds-NP_010237.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:277230-277751:+ | gene-YDL046W_MUCL42920 | rna-NM_001180105.1_MUCL42920 | cds-NP_010237.1_MUCL42920 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:371163-371684:+ | gene-YDL046W_NCIM3186 | rna-NM_001180105.1_NCIM3186 | cds-NP_010237.1_NCIM3186 | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:355194-355715:+ | gene-YDL046W_NCYC1407 | rna-NM_001180105.1_NCYC1407 | cds-NP_010237.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:362373-362894:+ | gene-YDL046W_PE2H3 | rna-NM_001180105.1_PE2H3 | cds-NP_010237.1_PE2H3 | 98.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:362375-362896:+ | gene-YDL046W_PE2H4 | rna-NM_001180105.1_PE2H4 | cds-NP_010237.1_PE2H4 | 98.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:371240-371761:+ | gene-YDL046W_S288C | rna-NM_001180105.1_S288C | cds-NP_010237.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000010.1:63166-63687:- | gene-YDL046W_SA1 | rna-NM_001180105.1_SA1 | cds-NP_010237.1_SA1 | 98.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:372332-372853:+ | gene-YDL046W_ThermosaccDry | rna-NM_001180105.1_ThermosaccDry | cds-NP_010237.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:375262-375783:+ | gene-YDL046W_VR1 | rna-NM_001180105.1_VR1 | cds-NP_010237.1_VR1 | 98.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:370273-370794:+ | gene-YDL046W_ZTW1 | rna-NM_001180105.1_ZTW1 | cds-NP_010237.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:372700-373221:+ | gene-YDL046W_Sparadoxus | rna-NM_001180105.1_Sparadoxus | cds-NP_010237.1_Sparadoxus | 90.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |