Gene name: NPA3
Reference locus (S288C): YJR072C
Gene biotype: protein_coding
Description: GPN-loop GTPase 1; Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress
Top 10 interactors (score): GPN2 (0.995); GPN3 (0.989); RPB2 (0.963); RPO21 (0.921); RPB5 (0.916); RTR1 (0.915); RPB3 (0.893); IWR1 (0.893); RBA50 (0.884); RVB1 (0.831); RAD14 (0.827); RVB2 (0.818); RPB11 (0.78); RPB7 (0.779); SEC27 (0.756); RPO26 (0.735); URB1 (0.735); GLC3 (0.723); AAR2 (0.709); FLO5 (0.697)
Homologues (species, bitscore): GPN1 (Homo sapiens, 347.8); Gpn1 (Mus musculus, 342.4); GPN1 (Danio rerio, 346.3); gpn3 (Xenopus tropicalis, 76.3); CG3704 (Drosophila melanogaster, 289.3); gop-2 (Caenorhabditis elegans, 331.3); QQT2 (Arabidopsis thaliana, 346.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:542492-543649:- | gene-YJR072C_AKU4011 | rna-NM_001181730.3_AKU4011 | cds-NP_012606.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000190.1:63968-65125:+ | gene-YJR072C_BG1 | rna-NM_001181730.3_BG1 | cds-NP_012606.3_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:556009-557166:- | gene-YJR072C_Bruggeman | rna-NM_001181730.3_Bruggeman | cds-NP_012606.3_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:560314-561471:- | gene-YJR072C_CAT1 | rna-NM_001181730.3_CAT1 | cds-NP_012606.3_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:554556-555713:- | gene-YJR072C_CBS1585 | rna-NM_001181730.3_CBS1585 | cds-NP_012606.3_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:572629-573786:- | gene-YJR072C_CBS436 | rna-NM_001181730.3_CBS436 | cds-NP_012606.3_CBS436 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:541705-542862:- | gene-YJR072C_CBS6412 | rna-NM_001181730.3_CBS6412 | cds-NP_012606.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:544003-545160:- | gene-YJR072C_CBS6413 | rna-NM_001181730.3_CBS6413 | cds-NP_012606.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:553327-554484:- | gene-YJR072C_CENPK1137D | rna-NM_001181730.3_CENPK1137D | cds-NP_012606.3_CENPK1137D | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:546885-548042:- | gene-YJR072C_EthanolRed | rna-NM_001181730.3_EthanolRed | cds-NP_012606.3_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:558351-559508:- | gene-YJR072C_FaliES1 | rna-NM_001181730.3_FaliES1 | cds-NP_012606.3_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000054.1:129874-131031:+ | gene-YJR072C_JAY291 | rna-NM_001181730.3_JAY291 | cds-NP_012606.3_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:556538-557695:- | gene-YJR072C_MUCL30387 | rna-NM_001181730.3_MUCL30387 | cds-NP_012606.3_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:553832-554989:- | gene-YJR072C_MUCL30388 | rna-NM_001181730.3_MUCL30388 | cds-NP_012606.3_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:548018-549175:- | gene-YJR072C_MUCL39482 | rna-NM_001181730.3_MUCL39482 | cds-NP_012606.3_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:552263-553420:- | gene-YJR072C_MUCL42920 | rna-NM_001181730.3_MUCL42920 | cds-NP_012606.3_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:570946-572103:- | gene-YJR072C_NCIM3186 | rna-NM_001181730.3_NCIM3186 | cds-NP_012606.3_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:545582-546739:- | gene-YJR072C_NCYC1407 | rna-NM_001181730.3_NCYC1407 | cds-NP_012606.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:563474-564631:- | gene-YJR072C_PE2H3 | rna-NM_001181730.3_PE2H3 | cds-NP_012606.3_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:557170-558327:- | gene-YJR072C_PE2H4 | rna-NM_001181730.3_PE2H4 | cds-NP_012606.3_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:570967-572124:- | gene-YJR072C_S288C | rna-NM_001181730.3_S288C | cds-NP_012606.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000038.1:29548-30705:- | gene-YJR072C_SA1 | rna-NM_001181730.3_SA1 | cds-NP_012606.3_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:552283-553440:- | gene-YJR072C_ThermosaccDry | rna-NM_001181730.3_ThermosaccDry | cds-NP_012606.3_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:554462-555619:- | gene-YJR072C_VR1 | rna-NM_001181730.3_VR1 | cds-NP_012606.3_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:531684-532841:- | gene-YJR072C_ZTW1 | rna-NM_001181730.3_ZTW1 | cds-NP_012606.3_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:565043-566212:- | gene-YJR072C_Sparadoxus | rna-NM_001181730.3_Sparadoxus | cds-NP_012606.3_Sparadoxus | 92.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |