Gene name: NOP2
Reference locus (S288C): YNL061W
Gene biotype: protein_coding
Description: rRNA m5C methyltransferase; methylates cytosine at position 2870 of 25S rRNA; has an essential function independent of rRNA methylation; contains seven beta-strand methyltransferase motif; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles; rRNA methylation defect and lethality are functionally complemented by human NOP2, a gene upregulated in cancer; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family
Top 10 interactors (score): NOG1 (0.999); TIF6 (0.999); CIC1 (0.999); RLP7 (0.999); DBP3 (0.999); PUF6 (0.999); BRX1 (0.999); MAK16 (0.999); NOC2 (0.999); NOP4 (0.999); MAK21 (0.999); NMD3 (0.999); DBP10 (0.999); NOP58 (0.999); NSA1 (0.999); HAS1 (0.999); NOP12 (0.999); NOP1 (0.999); NOG2 (0.999); NSA2 (0.999)
Homologues (species, bitscore): NOP2 (Homo sapiens, 498.8); Nop2 (Mus musculus, 512.7); nop2 (Danio rerio, 524.2); nop2 (Xenopus tropicalis, 478.0); CG8545 (Drosophila melanogaster, 496.9); nol-1 (Caenorhabditis elegans, 466.1); OLI2 (Arabidopsis thaliana, 495.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:504212-506068:+ | gene-YNL061W_AKU4011 | rna-NM_001182899.3_AKU4011 | cds-NP_014338.3_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:408221-410077:+ | gene-YNL061W_BG1 | rna-NM_001182899.3_BG1 | cds-NP_014338.3_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:514933-516789:+ | gene-YNL061W_Bruggeman | rna-NM_001182899.3_Bruggeman | cds-NP_014338.3_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:557925-559781:+ | gene-YNL061W_CAT1 | rna-NM_001182899.3_CAT1 | cds-NP_014338.3_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:504882-506738:+ | gene-YNL061W_CBS1585 | rna-NM_001182899.3_CBS1585 | cds-NP_014338.3_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:573182-575038:+ | gene-YNL061W_CBS436 | rna-NM_001182899.3_CBS436 | cds-NP_014338.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:499975-501831:+ | gene-YNL061W_CBS6412 | rna-NM_001182899.3_CBS6412 | cds-NP_014338.3_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:501291-503147:+ | gene-YNL061W_CBS6413 | rna-NM_001182899.3_CBS6413 | cds-NP_014338.3_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:504504-506360:+ | gene-YNL061W_CENPK1137D | rna-NM_001182899.3_CENPK1137D | cds-NP_014338.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:507034-508890:+ | gene-YNL061W_EthanolRed | rna-NM_001182899.3_EthanolRed | cds-NP_014338.3_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:497559-499415:+ | gene-YNL061W_FaliES1 | rna-NM_001182899.3_FaliES1 | cds-NP_014338.3_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000040.1:12655-14511:+ | gene-YNL061W_JAY291 | rna-NM_001182899.3_JAY291 | cds-NP_014338.3_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:511093-512949:+ | gene-YNL061W_MUCL30387 | rna-NM_001182899.3_MUCL30387 | cds-NP_014338.3_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:546746-548602:+ | gene-YNL061W_MUCL30388 | rna-NM_001182899.3_MUCL30388 | cds-NP_014338.3_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:502284-504140:+ | gene-YNL061W_MUCL39482 | rna-NM_001182899.3_MUCL39482 | cds-NP_014338.3_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:506198-508054:+ | gene-YNL061W_MUCL42920 | rna-NM_001182899.3_MUCL42920 | cds-NP_014338.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:510509-512365:+ | gene-YNL061W_NCIM3186 | rna-NM_001182899.3_NCIM3186 | cds-NP_014338.3_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:504335-506191:+ | gene-YNL061W_NCYC1407 | rna-NM_001182899.3_NCYC1407 | cds-NP_014338.3_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:507568-509424:+ | gene-YNL061W_PE2H3 | rna-NM_001182899.3_PE2H3 | cds-NP_014338.3_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:502643-504499:+ | gene-YNL061W_PE2H4 | rna-NM_001182899.3_PE2H4 | cds-NP_014338.3_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:510540-512396:+ | gene-YNL061W_S288C | rna-NM_001182899.3_S288C | cds-NP_014338.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000024.1:95489-97345:+ | gene-YNL061W_SA1 | rna-NM_001182899.3_SA1 | cds-NP_014338.3_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:498434-500290:+ | gene-YNL061W_ThermosaccDry | rna-NM_001182899.3_ThermosaccDry | cds-NP_014338.3_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:517531-519387:+ | gene-YNL061W_VR1 | rna-NM_001182899.3_VR1 | cds-NP_014338.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:407770-409626:+ | gene-YNL061W_ZTW1 | rna-NM_001182899.3_ZTW1 | cds-NP_014338.3_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:514020-515876:+ | gene-YNL061W_Sparadoxus | rna-NM_001182899.3_Sparadoxus | cds-NP_014338.3_Sparadoxus | 91.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |