Gene name: NNT1
Reference locus (S288C): YLR285W
Gene biotype: protein_coding
Description: Protein N-terminal and lysine N-methyltransferase EFM7; S-adenosylmethionine-dependent methyltransferase; novel N-terminal protein methyltransferase that trimethylates the N-terminal glycine residue (G2) and also dimethylates lysine (K3) on elongation factor eEF1A (Tef1p/Tef2p); has a role in rDNA silencing and in lifespan determination
Top 10 interactors (score): EFM5 (0.887); EFM6 (0.886); EFM4 (0.876); EFM2 (0.836); EFM3 (0.806); HPM1 (0.768); RKM4 (0.724); SET5 (0.719); NCL1 (0.695); HMT1 (0.688); TAE1 (0.675); YGR283C (0.675); NMA1 (0.674); OMS1 (0.633); DPH5 (0.621); YMR310C (0.617); AIM32 (0.616); RCM1 (0.586); RKM3 (0.586); RSM22 (0.575)
Homologues (species, bitscore): METTL21C (Homo sapiens, 55.8); Mettl21c (Mus musculus, 58.5); zgc:92518 (Danio rerio, 61.2); mettl21a (Xenopus tropicalis, 58.9); CG7889 (Drosophila melanogaster, 52.0); K01A11.2 (Caenorhabditis elegans, 53.5); AT2G26810 (Arabidopsis thaliana, 60.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:656157-656942:+ | gene-YLR285W_AKU4011 | rna-NM_001182172.1_AKU4011 | cds-NP_013387.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000170.1:75690-76475:- | gene-YLR285W_BG1 | rna-NM_001182172.1_BG1 | cds-NP_013387.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:691146-691931:+ | gene-YLR285W_Bruggeman | rna-NM_001182172.1_Bruggeman | cds-NP_013387.1_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:689967-690752:+ | gene-YLR285W_CAT1 | rna-NM_001182172.1_CAT1 | cds-NP_013387.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:691094-691879:+ | gene-YLR285W_CBS1585 | rna-NM_001182172.1_CBS1585 | cds-NP_013387.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:675742-676527:+ | gene-YLR285W_CBS436 | rna-NM_001182172.1_CBS436 | cds-NP_013387.1_CBS436 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:653728-654513:+ | gene-YLR285W_CBS6412 | rna-NM_001182172.1_CBS6412 | cds-NP_013387.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:691758-692543:+ | gene-YLR285W_CBS6413 | rna-NM_001182172.1_CBS6413 | cds-NP_013387.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:691959-692744:+ | gene-YLR285W_CENPK1137D | rna-NM_001182172.1_CENPK1137D | cds-NP_013387.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:649467-650252:+ | gene-YLR285W_EthanolRed | rna-NM_001182172.1_EthanolRed | cds-NP_013387.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:678667-679452:+ | gene-YLR285W_FaliES1 | rna-NM_001182172.1_FaliES1 | cds-NP_013387.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000359.1:26292-27077:- | gene-YLR285W_JAY291 | rna-NM_001182172.1_JAY291 | cds-NP_013387.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:691286-692071:+ | gene-YLR285W_MUCL30387 | rna-NM_001182172.1_MUCL30387 | cds-NP_013387.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:696619-697404:+ | gene-YLR285W_MUCL30388 | rna-NM_001182172.1_MUCL30388 | cds-NP_013387.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:692325-693110:+ | gene-YLR285W_MUCL39482 | rna-NM_001182172.1_MUCL39482 | cds-NP_013387.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:687535-688320:+ | gene-YLR285W_MUCL42920 | rna-NM_001182172.1_MUCL42920 | cds-NP_013387.1_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:707334-708119:+ | gene-YLR285W_NCIM3186 | rna-NM_001182172.1_NCIM3186 | cds-NP_013387.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:701657-702442:+ | gene-YLR285W_NCYC1407 | rna-NM_001182172.1_NCYC1407 | cds-NP_013387.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:689509-690294:+ | gene-YLR285W_PE2H3 | rna-NM_001182172.1_PE2H3 | cds-NP_013387.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:689253-690038:+ | gene-YLR285W_PE2H4 | rna-NM_001182172.1_PE2H4 | cds-NP_013387.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:707360-708145:+ | gene-YLR285W_S288C | rna-NM_001182172.1_S288C | cds-NP_013387.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000039.1:76486-77271:- | gene-YLR285W_SA1 | rna-NM_001182172.1_SA1 | cds-NP_013387.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:680563-681348:+ | gene-YLR285W_ThermosaccDry | rna-NM_001182172.1_ThermosaccDry | cds-NP_013387.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:692460-693245:+ | gene-YLR285W_VR1 | rna-NM_001182172.1_VR1 | cds-NP_013387.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:18969-19754:+ | gene-YLR285W_ZTW1 | rna-NM_001182172.1_ZTW1 | cds-NP_013387.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:666655-667440:+ | gene-YLR285W_Sparadoxus | rna-NM_001182172.1_Sparadoxus | cds-NP_013387.1_Sparadoxus | 90.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |