Gene name: NNR2
Reference locus (S288C): YKL151C
Gene biotype: protein_coding
Description: Widely-conserved NADHX dehydratase; converts (S)-NADHX to NADH in ATP-dependent manner; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; downstream intergenic region drives antisense expression and mediates coordinated regulation of YKL151C and GPM1 phosphoglycerate mutase; protein abundance increases in response to DNA replication stress; homolog of Carkd in mammals and C-terminus of YjeF in E.coli; Belongs to the NnrD/CARKD family
Top 10 interactors (score): NNR1 (0.987); GAD1 (0.934); TFS1 (0.929); MSC1 (0.923); SOL4 (0.922); PNC1 (0.921); DCS2 (0.919); MCR1 (0.911); STF2 (0.906); RTC3 (0.906); RTN2 (0.901); PGM2 (0.883); PDX3 (0.88); GOR1 (0.866); OM45 (0.854); YJR096W (0.849); YDL086W (0.845); GRE3 (0.838); GCY1 (0.813); YKL091C (0.809)
Homologues (species, bitscore): CARKD (Homo sapiens, 177.9); Carkd (Mus musculus, 217.6); CARKD (Danio rerio, 204.9); carkd (Xenopus tropicalis, 201.8); CG10424 (Drosophila melanogaster, 179.1); R107.2 (Caenorhabditis elegans, 157.1); AT5G19150 (Arabidopsis thaliana, 183.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:151794-152804:- | gene-YKL151C_AKU4011 | rna-NM_001179717.1_AKU4011 | cds-NP_012771.1_AKU4011 | 99.2 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000030.1:128929-129942:- | gene-YKL151C_BG1 | rna-NM_001179717.1_BG1 | cds-NP_012771.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:169452-170465:- | gene-YKL151C_Bruggeman | rna-NM_001179717.1_Bruggeman | cds-NP_012771.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:164782-165795:- | gene-YKL151C_CAT1 | rna-NM_001179717.1_CAT1 | cds-NP_012771.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:164019-165029:- | gene-YKL151C_CBS1585 | rna-NM_001179717.1_CBS1585 | cds-NP_012771.1_CBS1585 | 99.1 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:162625-163638:- | gene-YKL151C_CBS436 | rna-NM_001179717.1_CBS436 | cds-NP_012771.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:149039-150049:- | gene-YKL151C_CBS6412 | rna-NM_001179717.1_CBS6412 | cds-NP_012771.1_CBS6412 | 99.2 | 99.7 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:164489-165499:- | gene-YKL151C_CBS6413 | rna-NM_001179717.1_CBS6413 | cds-NP_012771.1_CBS6413 | 99.2 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:164561-165574:- | gene-YKL151C_CENPK1137D | rna-NM_001179717.1_CENPK1137D | cds-NP_012771.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:162536-163546:- | gene-YKL151C_EthanolRed | rna-NM_001179717.1_EthanolRed | cds-NP_012771.1_EthanolRed | 99.2 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:163348-164358:- | gene-YKL151C_FaliES1 | rna-NM_001179717.1_FaliES1 | cds-NP_012771.1_FaliES1 | 99.2 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000198.1:56-1069:- | gene-YKL151C_JAY291 | rna-NM_001179717.1_JAY291 | cds-NP_012771.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:171550-172563:- | gene-YKL151C_MUCL30387 | rna-NM_001179717.1_MUCL30387 | cds-NP_012771.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:165904-166914:- | gene-YKL151C_MUCL30388 | rna-NM_001179717.1_MUCL30388 | cds-NP_012771.1_MUCL30388 | 99.7 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:163825-164835:- | gene-YKL151C_MUCL39482 | rna-NM_001179717.1_MUCL39482 | cds-NP_012771.1_MUCL39482 | 99.3 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:168230-169240:- | gene-YKL151C_MUCL42920 | rna-NM_001179717.1_MUCL42920 | cds-NP_012771.1_MUCL42920 | 99.2 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:164906-165919:- | gene-YKL151C_NCIM3186 | rna-NM_001179717.1_NCIM3186 | cds-NP_012771.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:164016-165026:- | gene-YKL151C_NCYC1407 | rna-NM_001179717.1_NCYC1407 | cds-NP_012771.1_NCYC1407 | 99.2 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:171109-172122:- | gene-YKL151C_PE2H3 | rna-NM_001179717.1_PE2H3 | cds-NP_012771.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:167403-168416:- | gene-YKL151C_PE2H4 | rna-NM_001179717.1_PE2H4 | cds-NP_012771.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:164917-165930:- | gene-YKL151C_S288C | rna-NM_001179717.1_S288C | cds-NP_012771.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000008.1:81338-82351:- | gene-YKL151C_SA1 | rna-NM_001179717.1_SA1 | cds-NP_012771.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:164048-165058:- | gene-YKL151C_ThermosaccDry | rna-NM_001179717.1_ThermosaccDry | cds-NP_012771.1_ThermosaccDry | 99.2 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:163389-164402:- | gene-YKL151C_VR1 | rna-NM_001179717.1_VR1 | cds-NP_012771.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:162571-163584:- | gene-YKL151C_ZTW1 | rna-NM_001179717.1_ZTW1 | cds-NP_012771.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:179249-180262:- | gene-YKL151C_Sparadoxus | rna-NM_001179717.1_Sparadoxus | cds-NP_012771.1_Sparadoxus | 89.5 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |