Gene name: NHX1
Reference locus (S288C): YDR456W
Gene biotype: protein_coding
Description: Solute carrier family 9 (sodium/hydrogen exchanger), member 6/7; Endosomal/prevacuolar sodium/hydrogen exchanger; Na+/H+ and K+/H+ exchanger; required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion; ortholog of human NHE9, which is linked to autism; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
Top 10 interactors (score): KHA1 (0.989); NHA1 (0.98); VNX1 (0.971); ENA1 (0.926); TRK2 (0.901); TRK1 (0.9); GYP6 (0.88); VMA1 (0.834); TOK1 (0.794); ECM27 (0.76); YPT6 (0.751); YDR455C (0.749); PMR1 (0.743); YDL206W (0.742); CNB1 (0.733); YLH47 (0.723); MHO1 (0.702); YDR203W (0.7); VPH1 (0.692); MDM38 (0.691)
Homologues (species, bitscore): SLC9A7 (Homo sapiens, 277.7); Slc9a7 (Mus musculus, 277.7); slc9a6b (Danio rerio, 271.2); slc9a6 (Xenopus tropicalis, 280.0); Nhe1 (Drosophila melanogaster, 260.4); nhx-5 (Caenorhabditis elegans, 240.7); NHX5 (Arabidopsis thaliana, 227.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:1307390-1309291:+ | gene-YDR456W_AKU4011 | rna-NM_001180764.3_AKU4011 | cds-NP_010744.3_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000039.1:185749-187650:+ | gene-YDR456W_BG1 | rna-NM_001180764.3_BG1 | cds-NP_010744.3_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1338822-1340723:+ | gene-YDR456W_Bruggeman | rna-NM_001180764.3_Bruggeman | cds-NP_010744.3_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1315972-1317873:+ | gene-YDR456W_CAT1 | rna-NM_001180764.3_CAT1 | cds-NP_010744.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1301696-1303597:+ | gene-YDR456W_CBS1585 | rna-NM_001180764.3_CBS1585 | cds-NP_010744.3_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1321070-1322971:+ | gene-YDR456W_CBS436 | rna-NM_001180764.3_CBS436 | cds-NP_010744.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1297325-1299226:+ | gene-YDR456W_CBS6412 | rna-NM_001180764.3_CBS6412 | cds-NP_010744.3_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1320336-1322237:+ | gene-YDR456W_CBS6413 | rna-NM_001180764.3_CBS6413 | cds-NP_010744.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1366159-1368060:+ | gene-YDR456W_CENPK1137D | rna-NM_001180764.3_CENPK1137D | cds-NP_010744.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1310746-1312647:+ | gene-YDR456W_EthanolRed | rna-NM_001180764.3_EthanolRed | cds-NP_010744.3_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1314299-1316200:+ | gene-YDR456W_FaliES1 | rna-NM_001180764.3_FaliES1 | cds-NP_010744.3_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000026.1:12558-14459:+ | gene-YDR456W_JAY291 | rna-NM_001180764.3_JAY291 | cds-NP_010744.3_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1321313-1323214:+ | gene-YDR456W_MUCL30387 | rna-NM_001180764.3_MUCL30387 | cds-NP_010744.3_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1303338-1305239:+ | gene-YDR456W_MUCL30388 | rna-NM_001180764.3_MUCL30388 | cds-NP_010744.3_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:1293180-1295081:+ | gene-YDR456W_MUCL39482 | rna-NM_001180764.3_MUCL39482 | cds-NP_010744.3_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1235980-1237881:+ | gene-YDR456W_MUCL42920 | rna-NM_001180764.3_MUCL42920 | cds-NP_010744.3_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1367408-1369309:+ | gene-YDR456W_NCIM3186 | rna-NM_001180764.3_NCIM3186 | cds-NP_010744.3_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1306953-1308854:+ | gene-YDR456W_NCYC1407 | rna-NM_001180764.3_NCYC1407 | cds-NP_010744.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1317807-1319708:+ | gene-YDR456W_PE2H3 | rna-NM_001180764.3_PE2H3 | cds-NP_010744.3_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1323364-1325265:+ | gene-YDR456W_PE2H4 | rna-NM_001180764.3_PE2H4 | cds-NP_010744.3_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1367485-1369386:+ | gene-YDR456W_S288C | rna-NM_001180764.3_S288C | cds-NP_010744.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000004.1:247778-249679:- | gene-YDR456W_SA1 | rna-NM_001180764.3_SA1 | cds-NP_010744.3_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1318521-1320422:+ | gene-YDR456W_ThermosaccDry | rna-NM_001180764.3_ThermosaccDry | cds-NP_010744.3_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:1334258-1336159:+ | gene-YDR456W_VR1 | rna-NM_001180764.3_VR1 | cds-NP_010744.3_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:361197-363098:+ | gene-YDR456W_ZTW1 | rna-NM_001180764.3_ZTW1 | cds-NP_010744.3_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1321614-1323515:+ | gene-YDR456W_Sparadoxus | rna-NM_001180764.3_Sparadoxus | cds-NP_010744.3_Sparadoxus | 91.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |