Gene name: NHP6A
Reference locus (S288C): YPR052C
Gene biotype: protein_coding
Description: Non-histone chromosomal protein 6A; High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
Top 10 interactors (score): POB3 (0.991); SPT16 (0.972); ARP9 (0.947); ARP7 (0.919); HMO1 (0.907); HHT1 (0.904); HHO1 (0.876); ABF2 (0.87); STH1 (0.848); SNF2 (0.827); RSC6 (0.82); HHT2 (0.815); HTZ1 (0.808); SPT15 (0.799); IXR1 (0.798); BRF1 (0.788); RSC8 (0.781); AFT2 (0.78); NHP6B (0.776); YDL085C-A (0.768)
Homologues (species, bitscore): HMGB2 (Homo sapiens, 75.5); Hmgb1 (Mus musculus, 75.5); hmgb2a (Danio rerio, 81.3); ssrp1 (Xenopus tropicalis, 74.7); Dsp1 (Drosophila melanogaster, 80.1); hmg-1.2 (Caenorhabditis elegans, 79.0); HMG (Arabidopsis thaliana, 102.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:637358-637639:- | gene-YPR052C_AKU4011 | rna-NM_001184149.1_AKU4011 | cds-NP_015377.1_AKU4011 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:260040-260321:+ | gene-YPR052C_BG1 | rna-NM_001184149.1_BG1 | cds-NP_015377.1_BG1 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:715027-715308:- | gene-YPR052C_Bruggeman | rna-NM_001184149.1_Bruggeman | cds-NP_015377.1_Bruggeman | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:758481-758762:- | gene-YPR052C_CAT1 | rna-NM_001184149.1_CAT1 | cds-NP_015377.1_CAT1 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:641044-641325:- | gene-YPR052C_CBS1585 | rna-NM_001184149.1_CBS1585 | cds-NP_015377.1_CBS1585 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:655423-655704:- | gene-YPR052C_CBS436 | rna-NM_001184149.1_CBS436 | cds-NP_015377.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:644792-645073:- | gene-YPR052C_CBS6412 | rna-NM_001184149.1_CBS6412 | cds-NP_015377.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:637993-638274:- | gene-YPR052C_CBS6413 | rna-NM_001184149.1_CBS6413 | cds-NP_015377.1_CBS6413 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:665658-665939:- | gene-YPR052C_CENPK1137D | rna-NM_001184149.1_CENPK1137D | cds-NP_015377.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:964549-964830:- | gene-YPR052C_EthanolRed | rna-NM_001184149.1_EthanolRed | cds-NP_015377.1_EthanolRed | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:643186-643467:- | gene-YPR052C_FaliES1 | rna-NM_001184149.1_FaliES1 | cds-NP_015377.1_FaliES1 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000446.1:15144-15425:- | gene-YPR052C_JAY291 | rna-NM_001184149.1_JAY291 | cds-NP_015377.1_JAY291 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:656288-656569:- | gene-YPR052C_MUCL30387 | rna-NM_001184149.1_MUCL30387 | cds-NP_015377.1_MUCL30387 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:654992-655273:- | gene-YPR052C_MUCL30388 | rna-NM_001184149.1_MUCL30388 | cds-NP_015377.1_MUCL30388 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:634301-634582:- | gene-YPR052C_MUCL39482 | rna-NM_001184149.1_MUCL39482 | cds-NP_015377.1_MUCL39482 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:697129-697410:- | gene-YPR052C_MUCL42920 | rna-NM_001184149.1_MUCL42920 | cds-NP_015377.1_MUCL42920 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:665676-665957:- | gene-YPR052C_NCIM3186 | rna-NM_001184149.1_NCIM3186 | cds-NP_015377.1_NCIM3186 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:642231-642512:- | gene-YPR052C_NCYC1407 | rna-NM_001184149.1_NCYC1407 | cds-NP_015377.1_NCYC1407 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:648447-648728:- | gene-YPR052C_PE2H3 | rna-NM_001184149.1_PE2H3 | cds-NP_015377.1_PE2H3 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:648095-648376:- | gene-YPR052C_PE2H4 | rna-NM_001184149.1_PE2H4 | cds-NP_015377.1_PE2H4 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:665693-665974:- | gene-YPR052C_S288C | rna-NM_001184149.1_S288C | cds-NP_015377.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000026.1:34717-34998:+ | gene-YPR052C_SA1 | rna-NM_001184149.1_SA1 | cds-NP_015377.1_SA1 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:642961-643242:- | gene-YPR052C_ThermosaccDry | rna-NM_001184149.1_ThermosaccDry | cds-NP_015377.1_ThermosaccDry | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:659120-659401:- | gene-YPR052C_VR1 | rna-NM_001184149.1_VR1 | cds-NP_015377.1_VR1 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:642192-642473:- | gene-YPR052C_ZTW1 | rna-NM_001184149.1_ZTW1 | cds-NP_015377.1_ZTW1 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:642987-643268:- | gene-YPR052C_Sparadoxus | rna-NM_001184149.1_Sparadoxus | cds-NP_015377.1_Sparadoxus | 97.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |