Gene name: NFU1
Reference locus (S288C): YKL040C
Gene biotype: protein_coding
Description: NifU-like protein, mitochondrial; Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress; acts along with Bol3 at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to client proteins; Fe-S loaded homodimer at steady state; similar to NifU, a bacterial protein required for Fe/S cluster maturation; ortholog of the human NFU1, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS1)
Top 10 interactors (score): GRX5 (0.998); NFS1 (0.997); ISA1 (0.996); ISU1 (0.996); LIP5 (0.995); ISU2 (0.995); IBA57 (0.993); ISA2 (0.991); ISD11 (0.988); BOL3 (0.987); YAH1 (0.985); BOL1 (0.972); JAC1 (0.959); ACO1 (0.959); YFH1 (0.95); ATM1 (0.937); SSQ1 (0.93); MCX1 (0.929); SDH2 (0.919); TIS11 (0.908)
Homologues (species, bitscore): NFU1 (Homo sapiens, 142.1); Nfu1 (Mus musculus, 146.0); zgc:110319 (Danio rerio, 142.1); nfu1 (Xenopus tropicalis, 125.9); CG32857 (Drosophila melanogaster, 132.5); lpd-8 (Caenorhabditis elegans, 138.7); NFU4 (Arabidopsis thaliana, 141.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:347070-347840:- | gene-YKL040C_AKU4011 | rna-NM_001179606.3_AKU4011 | cds-NP_012884.3_AKU4011 | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000113.1:296147-296917:+ | gene-YKL040C_BG1 | rna-NM_001179606.3_BG1 | cds-NP_012884.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:366335-367105:- | gene-YKL040C_Bruggeman | rna-NM_001179606.3_Bruggeman | cds-NP_012884.3_Bruggeman | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:362518-363288:- | gene-YKL040C_CAT1 | rna-NM_001179606.3_CAT1 | cds-NP_012884.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:359797-360567:- | gene-YKL040C_CBS1585 | rna-NM_001179606.3_CBS1585 | cds-NP_012884.3_CBS1585 | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:357920-358690:- | gene-YKL040C_CBS436 | rna-NM_001179606.3_CBS436 | cds-NP_012884.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:343934-344704:- | gene-YKL040C_CBS6412 | rna-NM_001179606.3_CBS6412 | cds-NP_012884.3_CBS6412 | 98.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:359762-360532:- | gene-YKL040C_CBS6413 | rna-NM_001179606.3_CBS6413 | cds-NP_012884.3_CBS6413 | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:360716-361486:- | gene-YKL040C_CENPK1137D | rna-NM_001179606.3_CENPK1137D | cds-NP_012884.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:357752-358522:- | gene-YKL040C_EthanolRed | rna-NM_001179606.3_EthanolRed | cds-NP_012884.3_EthanolRed | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:358571-359341:- | gene-YKL040C_FaliES1 | rna-NM_001179606.3_FaliES1 | cds-NP_012884.3_FaliES1 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000080.1:63482-64252:- | gene-YKL040C_JAY291 | rna-NM_001179606.3_JAY291 | cds-NP_012884.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:367235-368005:- | gene-YKL040C_MUCL30387 | rna-NM_001179606.3_MUCL30387 | cds-NP_012884.3_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:362125-362895:- | gene-YKL040C_MUCL30388 | rna-NM_001179606.3_MUCL30388 | cds-NP_012884.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:359093-359863:- | gene-YKL040C_MUCL39482 | rna-NM_001179606.3_MUCL39482 | cds-NP_012884.3_MUCL39482 | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:363952-364722:- | gene-YKL040C_MUCL42920 | rna-NM_001179606.3_MUCL42920 | cds-NP_012884.3_MUCL42920 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:361047-361817:- | gene-YKL040C_NCIM3186 | rna-NM_001179606.3_NCIM3186 | cds-NP_012884.3_NCIM3186 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:359292-360062:- | gene-YKL040C_NCYC1407 | rna-NM_001179606.3_NCYC1407 | cds-NP_012884.3_NCYC1407 | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:383828-384598:- | gene-YKL040C_PE2H3 | rna-NM_001179606.3_PE2H3 | cds-NP_012884.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:368563-369333:- | gene-YKL040C_PE2H4 | rna-NM_001179606.3_PE2H4 | cds-NP_012884.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:361058-361828:- | gene-YKL040C_S288C | rna-NM_001179606.3_S288C | cds-NP_012884.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000027.1:39169-39939:- | gene-YKL040C_SA1 | rna-NM_001179606.3_SA1 | cds-NP_012884.3_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:359758-360528:- | gene-YKL040C_ThermosaccDry | rna-NM_001179606.3_ThermosaccDry | cds-NP_012884.3_ThermosaccDry | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:358899-359669:- | gene-YKL040C_VR1 | rna-NM_001179606.3_VR1 | cds-NP_012884.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:357771-358541:- | gene-YKL040C_ZTW1 | rna-NM_001179606.3_ZTW1 | cds-NP_012884.3_ZTW1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:377014-377784:- | gene-YKL040C_Sparadoxus | rna-NM_001179606.3_Sparadoxus | cds-NP_012884.3_Sparadoxus | 91.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |