Gene name: NFI1
Reference locus (S288C): YOR156C
Gene biotype: protein_coding
Description: SUMO E3 ligase; catalyzes sumoylation of Yku70p/80p and Sir4p promoting telomere anchoring to the nuclear envelope and regulating telomerase activity; DNA-bound form catalyzes a DNA-damaged triggered sumoylation wave resulting in multisite modification of several DNA repair proteins, enhancing interactions between these proteins and accelerating repair; sumoylates Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; role in telomere length maintenance; Belongs to the PIAS family
Top 10 interactors (score): SMT3 (0.999); UBC9 (0.999); MMS21 (0.996); AOS1 (0.981); UBA2 (0.98); ULP1 (0.98); ULP2 (0.98); SLX5 (0.967); SIZ1 (0.955); SLX8 (0.952); CST9 (0.94); SRS2 (0.922); SMC5 (0.909); ESC1 (0.902); RAD52 (0.89); MOT1 (0.88); TOP1 (0.878); SMC6 (0.852); TOP2 (0.838); ECM11 (0.836)
Homologues (species, bitscore): PIAS4 (Homo sapiens, 122.1); Pias4 (Mus musculus, 118.6); pias4a (Danio rerio, 123.2); pias4 (Xenopus tropicalis, 107.8); CG8068 (Drosophila melanogaster, 100.5); gei-17 (Caenorhabditis elegans, 85.5); AT5G41580 (Arabidopsis thaliana, 87.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:625984-628176:- | gene-YOR156C_AKU4011 | rna-NM_001183575.1_AKU4011 | cds-NP_014799.1_AKU4011 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000123.1:27741-29933:- | gene-YOR156C_BG1 | rna-NM_001183575.1_BG1 | cds-NP_014799.1_BG1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:610058-612250:- | gene-YOR156C_Bruggeman | rna-NM_001183575.1_Bruggeman | cds-NP_014799.1_Bruggeman | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:610076-612268:- | gene-YOR156C_CAT1 | rna-NM_001183575.1_CAT1 | cds-NP_014799.1_CAT1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:608485-610671:- | gene-YOR156C_CBS1585 | rna-NM_001183575.1_CBS1585 | cds-NP_014799.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:606780-608966:- | gene-YOR156C_CBS436 | rna-NM_001183575.1_CBS436 | cds-NP_014799.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:606097-608283:- | gene-YOR156C_CBS6412 | rna-NM_001183575.1_CBS6412 | cds-NP_014799.1_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:614772-616964:- | gene-YOR156C_CBS6413 | rna-NM_001183575.1_CBS6413 | cds-NP_014799.1_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:628116-630299:- | gene-YOR156C_CENPK1137D | rna-NM_001183575.1_CENPK1137D | cds-NP_014799.1_CENPK1137D | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:602196-604379:- | gene-YOR156C_EthanolRed | rna-NM_001183575.1_EthanolRed | cds-NP_014799.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:607049-609232:- | gene-YOR156C_FaliES1 | rna-NM_001183575.1_FaliES1 | cds-NP_014799.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000070.1:34306-36491:+ | gene-YOR156C_JAY291 | rna-NM_001183575.1_JAY291 | cds-NP_014799.1_JAY291 | 99.5 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:614865-617057:- | gene-YOR156C_MUCL30387 | rna-NM_001183575.1_MUCL30387 | cds-NP_014799.1_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:621622-623820:- | gene-YOR156C_MUCL30388 | rna-NM_001183575.1_MUCL30388 | cds-NP_014799.1_MUCL30388 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:616326-618512:- | gene-YOR156C_MUCL39482 | rna-NM_001183575.1_MUCL39482 | cds-NP_014799.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:625748-627934:- | gene-YOR156C_MUCL42920 | rna-NM_001183575.1_MUCL42920 | cds-NP_014799.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:628249-630429:- | gene-YOR156C_NCIM3186 | rna-NM_001183575.1_NCIM3186 | cds-NP_014799.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:616412-618598:- | gene-YOR156C_NCYC1407 | rna-NM_001183575.1_NCYC1407 | cds-NP_014799.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:614921-617110:- | gene-YOR156C_PE2H3 | rna-NM_001183575.1_PE2H3 | cds-NP_014799.1_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:625298-627487:- | gene-YOR156C_PE2H4 | rna-NM_001183575.1_PE2H4 | cds-NP_014799.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:628360-630540:- | gene-YOR156C_S288C | rna-NM_001183575.1_S288C | cds-NP_014799.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000006.1:44907-47096:- | gene-YOR156C_SA1 | rna-NM_001183575.1_SA1 | cds-NP_014799.1_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:606232-608415:- | gene-YOR156C_ThermosaccDry | rna-NM_001183575.1_ThermosaccDry | cds-NP_014799.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:669921-672113:- | gene-YOR156C_VR1 | rna-NM_001183575.1_VR1 | cds-NP_014799.1_VR1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:339685-341865:- | gene-YOR156C_ZTW1 | rna-NM_001183575.1_ZTW1 | cds-NP_014799.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:611378-613549:- | gene-YOR156C_Sparadoxus | rna-NM_001183575.1_Sparadoxus | cds-NP_014799.1_Sparadoxus | 88.9 | 99.5 | Verified | 1 | 1 | 1 | False | True | False | False | False |