Gene name: NDI1
Reference locus (S288C): YML120C
Gene biotype: protein_coding
Description: Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial; NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in respiratory chain but does not pump protons, in contrast to higher eukaryotic multisubunit respiratory complex I; upon apoptotic stress, is activated in mitochondria by N-terminal cleavage, then translocates to cytoplasm to induce apoptosis; homolog of human AIFM2; yeast NDI1 complements several phenotypes of human cell line with mutated MT-ND4, implicated in Leber hereditary optic neuropathy
Top 10 interactors (score): RIP1 (0.997); CYT1 (0.997); SDH2 (0.996); COR1 (0.993); SDH1 (0.993); QCR2 (0.99); COX4 (0.99); COX5A (0.988); COX6 (0.987); SDH4 (0.987); MDH1 (0.972); QCR7 (0.969); COX12 (0.964); COB (0.963); COX9 (0.955); ALD4 (0.95); SDH3 (0.947); QCR6 (0.945); COX2 (0.935); QCR8 (0.933)
Homologues (species, bitscore): AIFM2 (Danio rerio, 50.1); NDB3 (Arabidopsis thaliana, 299.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:21966-23507:- | gene-YML120C_AKU4011 | rna-NM_001182483.1_AKU4011 | cds-NP_013586.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000201.1:452666-454207:+ | gene-YML120C_BG1 | rna-NM_001182483.1_BG1 | cds-NP_013586.1_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:28178-29719:- | gene-YML120C_Bruggeman | rna-NM_001182483.1_Bruggeman | cds-NP_013586.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:29784-31325:- | gene-YML120C_CAT1 | rna-NM_001182483.1_CAT1 | cds-NP_013586.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:21965-23506:- | gene-YML120C_CBS1585 | rna-NM_001182483.1_CBS1585 | cds-NP_013586.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:27934-29475:- | gene-YML120C_CBS436 | rna-NM_001182483.1_CBS436 | cds-NP_013586.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:22728-24269:- | gene-YML120C_CBS6412 | rna-NM_001182483.1_CBS6412 | cds-NP_013586.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:21192-22733:- | gene-YML120C_CBS6413 | rna-NM_001182483.1_CBS6413 | cds-NP_013586.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:22781-24322:- | gene-YML120C_CENPK1137D | rna-NM_001182483.1_CENPK1137D | cds-NP_013586.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005483.1:22481-24022:- | gene-YML120C_EthanolRed | rna-NM_001182483.1_EthanolRed | cds-NP_013586.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:22758-24299:- | gene-YML120C_FaliES1 | rna-NM_001182483.1_FaliES1 | cds-NP_013586.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000345.1:65936-67477:+ | gene-YML120C_JAY291 | rna-NM_001182483.1_JAY291 | cds-NP_013586.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:26201-27742:- | gene-YML120C_MUCL30387 | rna-NM_001182483.1_MUCL30387 | cds-NP_013586.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:29872-31413:- | gene-YML120C_MUCL30388 | rna-NM_001182483.1_MUCL30388 | cds-NP_013586.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:21980-23521:- | gene-YML120C_MUCL39482 | rna-NM_001182483.1_MUCL39482 | cds-NP_013586.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:25644-27185:- | gene-YML120C_MUCL42920 | rna-NM_001182483.1_MUCL42920 | cds-NP_013586.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:28220-29761:- | gene-YML120C_NCIM3186 | rna-NM_001182483.1_NCIM3186 | cds-NP_013586.1_NCIM3186 | 94.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:22775-24316:- | gene-YML120C_NCYC1407 | rna-NM_001182483.1_NCYC1407 | cds-NP_013586.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:28164-29705:- | gene-YML120C_PE2H3 | rna-NM_001182483.1_PE2H3 | cds-NP_013586.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:28102-29643:- | gene-YML120C_PE2H4 | rna-NM_001182483.1_PE2H4 | cds-NP_013586.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:28266-29807:- | gene-YML120C_S288C | rna-NM_001182483.1_S288C | cds-NP_013586.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000054.1:20209-21750:- | gene-YML120C_SA1 | rna-NM_001182483.1_SA1 | cds-NP_013586.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:22056-23597:- | gene-YML120C_ThermosaccDry | rna-NM_001182483.1_ThermosaccDry | cds-NP_013586.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:26453-27994:- | gene-YML120C_VR1 | rna-NM_001182483.1_VR1 | cds-NP_013586.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000027.1:1539-3080:- | gene-YML120C_ZTW1 | rna-NM_001182483.1_ZTW1 | cds-NP_013586.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:33080-34621:- | gene-YML120C_Sparadoxus | rna-NM_001182483.1_Sparadoxus | cds-NP_013586.1_Sparadoxus | 91.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |