Gene name: NCR1
Reference locus (S288C): YPL006W
Gene biotype: protein_coding
Description: Niemann-Pick type C-related protein 1; Vacuolar membrane protein; transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCB), similar to the accumulation of high amounts of lipids observed in patients with Neimann-Pick C, a disease caused by loss-of-function mutations in NPC1, the functional ortholog of Ncr1p
Top 10 interactors (score): TYE7 (0.986); HMS1 (0.986); NPC2 (0.928); YPQ2 (0.816); ISC1 (0.785); RLF2 (0.782); FAB1 (0.734); YPL162C (0.731); YPQ1 (0.711); SNA2 (0.691); PKH1 (0.676); VPS30 (0.641); HRD1 (0.63); YDC1 (0.615); PHS1 (0.61); YPC1 (0.61); HMG2 (0.604); HMG1 (0.604); SAN1 (0.602); LAG1 (0.596)
Homologues (species, bitscore): NPC1 (Homo sapiens, 565.5); Npc1 (Mus musculus, 567.0); npc1 (Danio rerio, 544.3); npc1 (Xenopus tropicalis, 554.3); Npc1a (Drosophila melanogaster, 582.8); ncr-1 (Caenorhabditis elegans, 310.1); AT4G38350 (Arabidopsis thaliana, 591.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:516089-519601:+ | gene-YPL006W_AKU4011 | rna-NM_001183820.1_AKU4011 | cds-NP_015319.1_AKU4011 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:377574-381086:- | gene-YPL006W_BG1 | rna-NM_001183820.1_BG1 | cds-NP_015319.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:593030-596542:+ | gene-YPL006W_Bruggeman | rna-NM_001183820.1_Bruggeman | cds-NP_015319.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:635776-639288:+ | gene-YPL006W_CAT1 | rna-NM_001183820.1_CAT1 | cds-NP_015319.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:520266-523778:+ | gene-YPL006W_CBS1585 | rna-NM_001183820.1_CBS1585 | cds-NP_015319.1_CBS1585 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:534332-537844:+ | gene-YPL006W_CBS436 | rna-NM_001183820.1_CBS436 | cds-NP_015319.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:524015-527527:+ | gene-YPL006W_CBS6412 | rna-NM_001183820.1_CBS6412 | cds-NP_015319.1_CBS6412 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:516726-520238:+ | gene-YPL006W_CBS6413 | rna-NM_001183820.1_CBS6413 | cds-NP_015319.1_CBS6413 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:544632-548144:+ | gene-YPL006W_CENPK1137D | rna-NM_001183820.1_CENPK1137D | cds-NP_015319.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:514513-518025:+ | gene-YPL006W_EthanolRed | rna-NM_001183820.1_EthanolRed | cds-NP_015319.1_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:522343-525855:+ | gene-YPL006W_FaliES1 | rna-NM_001183820.1_FaliES1 | cds-NP_015319.1_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000341.1:12158-15670:- | gene-YPL006W_JAY291 | rna-NM_001183820.1_JAY291 | cds-NP_015319.1_JAY291 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:533983-537495:+ | gene-YPL006W_MUCL30387 | rna-NM_001183820.1_MUCL30387 | cds-NP_015319.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:533087-536599:+ | gene-YPL006W_MUCL30388 | rna-NM_001183820.1_MUCL30388 | cds-NP_015319.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:513506-517018:+ | gene-YPL006W_MUCL39482 | rna-NM_001183820.1_MUCL39482 | cds-NP_015319.1_MUCL39482 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:572601-576113:+ | gene-YPL006W_MUCL42920 | rna-NM_001183820.1_MUCL42920 | cds-NP_015319.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:544614-548126:+ | gene-YPL006W_NCIM3186 | rna-NM_001183820.1_NCIM3186 | cds-NP_015319.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:520765-524277:+ | gene-YPL006W_NCYC1407 | rna-NM_001183820.1_NCYC1407 | cds-NP_015319.1_NCYC1407 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:527463-530975:+ | gene-YPL006W_PE2H3 | rna-NM_001183820.1_PE2H3 | cds-NP_015319.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:527078-530590:+ | gene-YPL006W_PE2H4 | rna-NM_001183820.1_PE2H4 | cds-NP_015319.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:544631-548143:+ | gene-YPL006W_S288C | rna-NM_001183820.1_S288C | cds-NP_015319.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000076.1:41372-44884:+ | gene-YPL006W_SA1 | rna-NM_001183820.1_SA1 | cds-NP_015319.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:522142-525654:+ | gene-YPL006W_ThermosaccDry | rna-NM_001183820.1_ThermosaccDry | cds-NP_015319.1_ThermosaccDry | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:537540-541052:+ | gene-YPL006W_VR1 | rna-NM_001183820.1_VR1 | cds-NP_015319.1_VR1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:521448-524960:+ | gene-YPL006W_ZTW1 | rna-NM_001183820.1_ZTW1 | cds-NP_015319.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:521294-524806:+ | gene-YPL006W_Sparadoxus | rna-NM_001183820.1_Sparadoxus | cds-NP_015319.1_Sparadoxus | 89.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |