Gene name: NCL1
Reference locus (S288C): YBL024W
Gene biotype: protein_coding
Description: Multisite-specific tRNA:(cytosine-C(5))-methyltransferase; S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120
Top 10 interactors (score): TRM8 (0.999); TRM1 (0.995); SPB1 (0.994); TRM7 (0.994); GCD10 (0.993); RAT1 (0.991); TRM11 (0.99); NOP58 (0.986); GCD14 (0.984); PWP2 (0.981); TRM2 (0.981); NOP7 (0.98); NOP4 (0.979); MAK5 (0.979); PUS7 (0.979); NOG1 (0.978); NOP56 (0.977); NOP2 (0.977); MRT4 (0.975); TRM82 (0.975)
Homologues (species, bitscore): NSUN2 (Homo sapiens, 438.3); Nsun2 (Mus musculus, 442.2); nsun2 (Danio rerio, 447.6); nsun2 (Xenopus tropicalis, 431.0); Nsun2 (Drosophila melanogaster, 391.3); Y48G8AL.5 (Caenorhabditis elegans, 370.2); AT2G22400 (Arabidopsis thaliana, 390.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:166146-168200:+ | gene-YBL024W_AKU4011 | rna-NM_001178264.1_AKU4011 | cds-NP_009529.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:156973-159021:+ | gene-YBL024W_BG1 | rna-NM_001178264.1_BG1 | cds-NP_009529.1_BG1 | 99.2 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:166731-168779:+ | gene-YBL024W_Bruggeman | rna-NM_001178264.1_Bruggeman | cds-NP_009529.1_Bruggeman | 99.3 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:169343-171391:+ | gene-YBL024W_CAT1 | rna-NM_001178264.1_CAT1 | cds-NP_009529.1_CAT1 | 99.3 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:158701-160755:+ | gene-YBL024W_CBS1585 | rna-NM_001178264.1_CBS1585 | cds-NP_009529.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:167152-169200:+ | gene-YBL024W_CBS436 | rna-NM_001178264.1_CBS436 | cds-NP_009529.1_CBS436 | 99.2 | 99.7 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:257480-259534:+ | gene-YBL024W_CBS6412 | rna-NM_001178264.1_CBS6412 | cds-NP_009529.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:164271-166325:+ | gene-YBL024W_CBS6413 | rna-NM_001178264.1_CBS6413 | cds-NP_009529.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:166300-168354:+ | gene-YBL024W_CENPK1137D | rna-NM_001178264.1_CENPK1137D | cds-NP_009529.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:293688-295742:+ | gene-YBL024W_EthanolRed | rna-NM_001178264.1_EthanolRed | cds-NP_009529.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:180954-183008:+ | gene-YBL024W_FaliES1 | rna-NM_001178264.1_FaliES1 | cds-NP_009529.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000421.1:6626-8674:+ | gene-YBL024W_JAY291 | rna-NM_001178264.1_JAY291 | cds-NP_009529.1_JAY291 | 99.1 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:166340-168351:+ | gene-YBL024W_MUCL30387 | rna-NM_001178264.1_MUCL30387 | cds-NP_009529.1_MUCL30387 | 97.1 | 97.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:167631-169679:+ | gene-YBL024W_MUCL30388 | rna-NM_001178264.1_MUCL30388 | cds-NP_009529.1_MUCL30388 | 99.2 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:158886-160940:+ | gene-YBL024W_MUCL39482 | rna-NM_001178264.1_MUCL39482 | cds-NP_009529.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:165912-167923:+ | gene-YBL024W_MUCL42920 | rna-NM_001178264.1_MUCL42920 | cds-NP_009529.1_MUCL42920 | 96.9 | 97.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:172331-174385:+ | gene-YBL024W_NCIM3186 | rna-NM_001178264.1_NCIM3186 | cds-NP_009529.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:160035-162089:+ | gene-YBL024W_NCYC1407 | rna-NM_001178264.1_NCYC1407 | cds-NP_009529.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:166262-168310:+ | gene-YBL024W_PE2H3 | rna-NM_001178264.1_PE2H3 | cds-NP_009529.1_PE2H3 | 99.1 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:163906-165954:+ | gene-YBL024W_PE2H4 | rna-NM_001178264.1_PE2H4 | cds-NP_009529.1_PE2H4 | 99.1 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:172534-174588:+ | gene-YBL024W_S288C | rna-NM_001178264.1_S288C | cds-NP_009529.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000051.1:57200-59248:+ | gene-YBL024W_SA1 | rna-NM_001178264.1_SA1 | cds-NP_009529.1_SA1 | 99.3 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:180909-182963:+ | gene-YBL024W_ThermosaccDry | rna-NM_001178264.1_ThermosaccDry | cds-NP_009529.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:163075-165123:+ | gene-YBL024W_VR1 | rna-NM_001178264.1_VR1 | cds-NP_009529.1_VR1 | 99.3 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:157623-159676:+ | gene-YBL024W_ZTW1 | rna-NM_001178264.1_ZTW1 | cds-NP_009529.1_ZTW1 | 99.9 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:192576-194624:+ | gene-YBL024W_Sparadoxus | rna-NM_001178264.1_Sparadoxus | cds-NP_009529.1_Sparadoxus | 91.6 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |