Gene name: NAM2
Reference locus (S288C): YLR382C
Gene biotype: protein_coding
Description: Leucine--tRNA ligase, mitochondrial; Mitochondrial leucyl-tRNA synthetase; also has direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance; human homolog LARS2 can complement yeast null mutant, and is implicated in Perrault syndrome; Belongs to the class-I aminoacyl-tRNA synthetase family
Top 10 interactors (score): YDR341C (0.995); TYS1 (0.992); MES1 (0.986); AIM10 (0.984); GUS1 (0.98); MSY1 (0.98); SES1 (0.978); DIA4 (0.973); ISM1 (0.972); BI4 (0.969); MSR1 (0.967); MSF1 (0.966); GLN4 (0.965); MSE1 (0.962); SLM5 (0.951); MSW1 (0.95); WRS1 (0.937); MST1 (0.937); MSK1 (0.937); GTR1 (0.934)
Homologues (species, bitscore): LARS2 (Homo sapiens, 543.9); Lars2 (Mus musculus, 552.4); lars2 (Danio rerio, 461.1); lars2 (Xenopus tropicalis, 504.2); Aats-leu (Drosophila melanogaster, 476.9); lars-2 (Caenorhabditis elegans, 411.8); EMB2369 (Arabidopsis thaliana, 466.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:831605-834289:- | gene-YLR382C_AKU4011 | rna-NM_001182271.3_AKU4011 | cds-NP_013486.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000048.1:63781-66465:- | gene-YLR382C_BG1 | rna-NM_001182271.3_BG1 | cds-NP_013486.3_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:869910-872594:- | gene-YLR382C_Bruggeman | rna-NM_001182271.3_Bruggeman | cds-NP_013486.3_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:865433-868117:- | gene-YLR382C_CAT1 | rna-NM_001182271.3_CAT1 | cds-NP_013486.3_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:867201-869885:- | gene-YLR382C_CBS1585 | rna-NM_001182271.3_CBS1585 | cds-NP_013486.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:850839-853523:- | gene-YLR382C_CBS436 | rna-NM_001182271.3_CBS436 | cds-NP_013486.3_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:903242-905926:- | gene-YLR382C_CBS6412 | rna-NM_001182271.3_CBS6412 | cds-NP_013486.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:867492-870176:- | gene-YLR382C_CBS6413 | rna-NM_001182271.3_CBS6413 | cds-NP_013486.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:866845-869529:- | gene-YLR382C_CENPK1137D | rna-NM_001182271.3_CENPK1137D | cds-NP_013486.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:824184-826831:- | gene-YLR382C_EthanolRed | rna-NM_001182271.3_EthanolRed | cds-NP_013486.3_EthanolRed | 97.0 | 98.3 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:853457-856141:- | gene-YLR382C_FaliES1 | rna-NM_001182271.3_FaliES1 | cds-NP_013486.3_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000434.1:6614-9298:- | gene-YLR382C_JAY291 | rna-NM_001182271.3_JAY291 | cds-NP_013486.3_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:868421-871105:- | gene-YLR382C_MUCL30387 | rna-NM_001182271.3_MUCL30387 | cds-NP_013486.3_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:874862-877546:- | gene-YLR382C_MUCL30388 | rna-NM_001182271.3_MUCL30388 | cds-NP_013486.3_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:868421-871105:- | gene-YLR382C_MUCL39482 | rna-NM_001182271.3_MUCL39482 | cds-NP_013486.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:863078-865762:- | gene-YLR382C_MUCL42920 | rna-NM_001182271.3_MUCL42920 | cds-NP_013486.3_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:882041-884725:- | gene-YLR382C_NCIM3186 | rna-NM_001182271.3_NCIM3186 | cds-NP_013486.3_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:877601-880285:- | gene-YLR382C_NCYC1407 | rna-NM_001182271.3_NCYC1407 | cds-NP_013486.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:863993-866677:- | gene-YLR382C_PE2H3 | rna-NM_001182271.3_PE2H3 | cds-NP_013486.3_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:863737-866421:- | gene-YLR382C_PE2H4 | rna-NM_001182271.3_PE2H4 | cds-NP_013486.3_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:882067-884751:- | gene-YLR382C_S288C | rna-NM_001182271.3_S288C | cds-NP_013486.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000007.1:163938-166622:+ | gene-YLR382C_SA1 | rna-NM_001182271.3_SA1 | cds-NP_013486.3_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:856536-859220:- | gene-YLR382C_ThermosaccDry | rna-NM_001182271.3_ThermosaccDry | cds-NP_013486.3_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:869083-871767:- | gene-YLR382C_VR1 | rna-NM_001182271.3_VR1 | cds-NP_013486.3_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:193253-195937:- | gene-YLR382C_ZTW1 | rna-NM_001182271.3_ZTW1 | cds-NP_013486.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:841901-844585:- | gene-YLR382C_Sparadoxus | rna-NM_001182271.3_Sparadoxus | cds-NP_013486.3_Sparadoxus | 89.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |