Gene name: NAB3
Reference locus (S288C): YPL190C
Gene biotype: protein_coding
Description: RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing; Nrd1-Nab3 pathway appears to have a role in rapid suppression of some genes when cells are shifted to poor growth conditions, indicating role for Nrd1-Nab3 in regulating cellular response to nutrient availability
Top 10 interactors (score): SEN1 (0.999); NRD1 (0.999); RRP6 (0.995); MTR4 (0.986); RAT1 (0.974); AIR2 (0.971); AIR1 (0.97); PCF11 (0.969); CBC2 (0.963); SSU72 (0.959); STO1 (0.942); RPO21 (0.925); RNT1 (0.925); PAP2 (0.922); RTT103 (0.917); NUP2 (0.916); GLE2 (0.912); YRB2 (0.911); TYR1 (0.911); YRB1 (0.911)
Homologues (species, bitscore): WDR87 (Homo sapiens, 72.4); Ncl (Mus musculus, 60.5); srsf4 (Danio rerio, 57.4); rbm28 (Xenopus tropicalis, 69.7); spen (Drosophila melanogaster, 60.1); arid-1 (Caenorhabditis elegans, 55.8); UBA2A (Arabidopsis thaliana, 52.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:163164-165566:- | gene-YPL190C_AKU4011 | rna-NM_001184004.1_AKU4011 | cds-NP_015134.1_AKU4011 | 98.8 | 99.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:368956-371361:- | gene-YPL190C_BG1 | rna-NM_001184004.1_BG1 | cds-NP_015134.1_BG1 | 99.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:189150-191581:- | gene-YPL190C_Bruggeman | rna-NM_001184004.1_Bruggeman | cds-NP_015134.1_Bruggeman | 97.5 | 99.7 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:185505-187910:- | gene-YPL190C_CAT1 | rna-NM_001184004.1_CAT1 | cds-NP_015134.1_CAT1 | 99.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:167353-169782:- | gene-YPL190C_CBS1585 | rna-NM_001184004.1_CBS1585 | cds-NP_015134.1_CBS1585 | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:182046-184451:- | gene-YPL190C_CBS436 | rna-NM_001184004.1_CBS436 | cds-NP_015134.1_CBS436 | 99.8 | 99.8 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:172115-174517:- | gene-YPL190C_CBS6412 | rna-NM_001184004.1_CBS6412 | cds-NP_015134.1_CBS6412 | 98.8 | 99.6 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:163525-165927:- | gene-YPL190C_CBS6413 | rna-NM_001184004.1_CBS6413 | cds-NP_015134.1_CBS6413 | 98.8 | 99.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:185264-187672:- | gene-YPL190C_CENPK1137D | rna-NM_001184004.1_CENPK1137D | cds-NP_015134.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:162284-164719:- | gene-YPL190C_EthanolRed | rna-NM_001184004.1_EthanolRed | cds-NP_015134.1_EthanolRed | 97.9 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:169655-172090:- | gene-YPL190C_FaliES1 | rna-NM_001184004.1_FaliES1 | cds-NP_015134.1_FaliES1 | 97.9 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000267.1:10682-12703:- | gene-YPL190C_JAY291 | rna-NM_001184004.1_JAY291 | cds-NP_015134.1_JAY291 | 83.9 | 83.9 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:180537-182956:- | gene-YPL190C_MUCL30387 | rna-NM_001184004.1_MUCL30387 | cds-NP_015134.1_MUCL30387 | 97.9 | 99.7 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:178692-181099:- | gene-YPL190C_MUCL30388 | rna-NM_001184004.1_MUCL30388 | cds-NP_015134.1_MUCL30388 | 98.0 | 99.5 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:160682-163111:- | gene-YPL190C_MUCL39482 | rna-NM_001184004.1_MUCL39482 | cds-NP_015134.1_MUCL39482 | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:217525-219920:- | gene-YPL190C_MUCL42920 | rna-NM_001184004.1_MUCL42920 | cds-NP_015134.1_MUCL42920 | 97.7 | 99.3 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:185300-187708:- | gene-YPL190C_NCIM3186 | rna-NM_001184004.1_NCIM3186 | cds-NP_015134.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:167049-169460:- | gene-YPL190C_NCYC1407 | rna-NM_001184004.1_NCYC1407 | cds-NP_015134.1_NCYC1407 | 98.4 | 99.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:174667-177072:- | gene-YPL190C_PE2H3 | rna-NM_001184004.1_PE2H3 | cds-NP_015134.1_PE2H3 | 99.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:174310-176715:- | gene-YPL190C_PE2H4 | rna-NM_001184004.1_PE2H4 | cds-NP_015134.1_PE2H4 | 99.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:185317-187725:- | gene-YPL190C_S288C | rna-NM_001184004.1_S288C | cds-NP_015134.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000012.1:185628-188033:+ | gene-YPL190C_SA1 | rna-NM_001184004.1_SA1 | cds-NP_015134.1_SA1 | 99.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:169434-171869:- | gene-YPL190C_ThermosaccDry | rna-NM_001184004.1_ThermosaccDry | cds-NP_015134.1_ThermosaccDry | 97.9 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:184441-186846:- | gene-YPL190C_VR1 | rna-NM_001184004.1_VR1 | cds-NP_015134.1_VR1 | 99.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:168787-171183:- | gene-YPL190C_ZTW1 | rna-NM_001184004.1_ZTW1 | cds-NP_015134.1_ZTW1 | 98.8 | 99.5 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:170357-172792:- | gene-YPL190C_Sparadoxus | rna-NM_001184004.1_Sparadoxus | cds-NP_015134.1_Sparadoxus | 87.8 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |