Gene name: MUS81
Reference locus (S288C): YDR386W
Gene biotype: protein_coding
Description: Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); helix-hairpin-helix protein; phosphorylation of non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates function of Mms4p-Mus81p; Belongs to the XPF family
Top 10 interactors (score): MMS4 (0.999); YEN1 (0.999); RAD10 (0.999); SGS1 (0.999); RMI1 (0.999); TOP3 (0.999); SLX1 (0.999); RAD51 (0.998); RAD54 (0.998); SPO11 (0.998); SRS2 (0.997); RAD52 (0.997); RAD53 (0.997); RAD1 (0.995); MPH1 (0.995); DUN1 (0.993); RAD27 (0.993); MSH4 (0.992); RAD57 (0.989); DNA2 (0.988)
Homologues (species, bitscore): MUS81 (Homo sapiens, 129.4); Mus81 (Mus musculus, 127.1); mus81 (Danio rerio, 147.9); mus81 (Xenopus tropicalis, 166.8); mus81 (Drosophila melanogaster, 117.1); mus-81 (Caenorhabditis elegans, 77.0); MUS81 (Arabidopsis thaliana, 107.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:1186225-1188123:+ | gene-YDR386W_AKU4011 | rna-NM_001180694.3_AKU4011 | cds-NP_010674.3_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000039.1:64709-66607:+ | gene-YDR386W_BG1 | rna-NM_001180694.3_BG1 | cds-NP_010674.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1217110-1219008:+ | gene-YDR386W_Bruggeman | rna-NM_001180694.3_Bruggeman | cds-NP_010674.3_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1195665-1197563:+ | gene-YDR386W_CAT1 | rna-NM_001180694.3_CAT1 | cds-NP_010674.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1181185-1183083:+ | gene-YDR386W_CBS1585 | rna-NM_001180694.3_CBS1585 | cds-NP_010674.3_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1200013-1201911:+ | gene-YDR386W_CBS436 | rna-NM_001180694.3_CBS436 | cds-NP_010674.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1177232-1179130:+ | gene-YDR386W_CBS6412 | rna-NM_001180694.3_CBS6412 | cds-NP_010674.3_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1199093-1200991:+ | gene-YDR386W_CBS6413 | rna-NM_001180694.3_CBS6413 | cds-NP_010674.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1244743-1246641:+ | gene-YDR386W_CENPK1137D | rna-NM_001180694.3_CENPK1137D | cds-NP_010674.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1190630-1192528:+ | gene-YDR386W_EthanolRed | rna-NM_001180694.3_EthanolRed | cds-NP_010674.3_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1193940-1195838:+ | gene-YDR386W_FaliES1 | rna-NM_001180694.3_FaliES1 | cds-NP_010674.3_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000181.1:59697-61595:- | gene-YDR386W_JAY291 | rna-NM_001180694.3_JAY291 | cds-NP_010674.3_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1200672-1202570:+ | gene-YDR386W_MUCL30387 | rna-NM_001180694.3_MUCL30387 | cds-NP_010674.3_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1182785-1184683:+ | gene-YDR386W_MUCL30388 | rna-NM_001180694.3_MUCL30388 | cds-NP_010674.3_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:1172513-1174411:+ | gene-YDR386W_MUCL39482 | rna-NM_001180694.3_MUCL39482 | cds-NP_010674.3_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1114912-1116810:+ | gene-YDR386W_MUCL42920 | rna-NM_001180694.3_MUCL42920 | cds-NP_010674.3_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1246007-1247905:+ | gene-YDR386W_NCIM3186 | rna-NM_001180694.3_NCIM3186 | cds-NP_010674.3_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1186484-1188382:+ | gene-YDR386W_NCYC1407 | rna-NM_001180694.3_NCYC1407 | cds-NP_010674.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1196572-1198470:+ | gene-YDR386W_PE2H3 | rna-NM_001180694.3_PE2H3 | cds-NP_010674.3_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1202146-1204044:+ | gene-YDR386W_PE2H4 | rna-NM_001180694.3_PE2H4 | cds-NP_010674.3_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1246084-1247982:+ | gene-YDR386W_S288C | rna-NM_001180694.3_S288C | cds-NP_010674.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000071.1:59810-61708:- | gene-YDR386W_SA1 | rna-NM_001180694.3_SA1 | cds-NP_010674.3_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1198202-1200100:+ | gene-YDR386W_ThermosaccDry | rna-NM_001180694.3_ThermosaccDry | cds-NP_010674.3_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:1213385-1215283:+ | gene-YDR386W_VR1 | rna-NM_001180694.3_VR1 | cds-NP_010674.3_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:241014-242912:+ | gene-YDR386W_ZTW1 | rna-NM_001180694.3_ZTW1 | cds-NP_010674.3_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1192793-1194691:+ | gene-YDR386W_Sparadoxus | rna-NM_001180694.3_Sparadoxus | cds-NP_010674.3_Sparadoxus | 87.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |