Gene name: MTR4
Reference locus (S288C): YJL050W
Gene biotype: protein_coding
Description: ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing; Belongs to the helicase family. SKI2 subfamily
Top 10 interactors (score): SOF1 (0.999); NOP14 (0.999); UTP7 (0.999); UTP10 (0.999); HCA4 (0.999); UTP14 (0.999); AIR1 (0.999); NOC4 (0.999); UTP21 (0.999); LRP1 (0.999); RRP6 (0.999); RRP43 (0.999); RRP40 (0.999); RRP5 (0.999); AIR2 (0.999); RRP46 (0.999); BMS1 (0.999); CSL4 (0.999); TRF5 (0.999); ECM16 (0.999)
Homologues (species, bitscore): SKIV2L2 (Homo sapiens, 1105.1); Skiv2l2 (Mus musculus, 1112.8); skiv2l2 (Danio rerio, 1105.1); SKIV2L2 (Xenopus tropicalis, 1119.4); l(2)35Df (Drosophila melanogaster, 1071.2); mtr-4 (Caenorhabditis elegans, 906.7); MTR4 (Arabidopsis thaliana, 964.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:325332-328553:+ | gene-YJL050W_AKU4011 | rna-NM_001181483.1_AKU4011 | cds-NP_012485.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000190.1:285242-288463:- | gene-YJL050W_BG1 | rna-NM_001181483.1_BG1 | cds-NP_012485.1_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:337910-341131:+ | gene-YJL050W_Bruggeman | rna-NM_001181483.1_Bruggeman | cds-NP_012485.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:343147-346368:+ | gene-YJL050W_CAT1 | rna-NM_001181483.1_CAT1 | cds-NP_012485.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:336986-340207:+ | gene-YJL050W_CBS1585 | rna-NM_001181483.1_CBS1585 | cds-NP_012485.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:355037-358258:+ | gene-YJL050W_CBS436 | rna-NM_001181483.1_CBS436 | cds-NP_012485.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:326091-329312:+ | gene-YJL050W_CBS6412 | rna-NM_001181483.1_CBS6412 | cds-NP_012485.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:327438-330659:+ | gene-YJL050W_CBS6413 | rna-NM_001181483.1_CBS6413 | cds-NP_012485.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:324986-328207:+ | gene-YJL050W_CENPK1137D | rna-NM_001181483.1_CENPK1137D | cds-NP_012485.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:329170-332391:+ | gene-YJL050W_EthanolRed | rna-NM_001181483.1_EthanolRed | cds-NP_012485.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:340744-343965:+ | gene-YJL050W_FaliES1 | rna-NM_001181483.1_FaliES1 | cds-NP_012485.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000210.1:8931-12152:- | gene-YJL050W_JAY291 | rna-NM_001181483.1_JAY291 | cds-NP_012485.1_JAY291 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:339065-342286:+ | gene-YJL050W_MUCL30387 | rna-NM_001181483.1_MUCL30387 | cds-NP_012485.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:335105-338326:+ | gene-YJL050W_MUCL30388 | rna-NM_001181483.1_MUCL30388 | cds-NP_012485.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:329740-332961:+ | gene-YJL050W_MUCL39482 | rna-NM_001181483.1_MUCL39482 | cds-NP_012485.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:336434-339655:+ | gene-YJL050W_MUCL42920 | rna-NM_001181483.1_MUCL42920 | cds-NP_012485.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:342501-345722:+ | gene-YJL050W_NCIM3186 | rna-NM_001181483.1_NCIM3186 | cds-NP_012485.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:328436-331657:+ | gene-YJL050W_NCYC1407 | rna-NM_001181483.1_NCYC1407 | cds-NP_012485.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:340834-344055:+ | gene-YJL050W_PE2H3 | rna-NM_001181483.1_PE2H3 | cds-NP_012485.1_PE2H3 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:340479-343700:+ | gene-YJL050W_PE2H4 | rna-NM_001181483.1_PE2H4 | cds-NP_012485.1_PE2H4 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:342522-345743:+ | gene-YJL050W_S288C | rna-NM_001181483.1_S288C | cds-NP_012485.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000003.1:138394-141615:+ | gene-YJL050W_SA1 | rna-NM_001181483.1_SA1 | cds-NP_012485.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:334157-337378:+ | gene-YJL050W_ThermosaccDry | rna-NM_001181483.1_ThermosaccDry | cds-NP_012485.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:336647-339868:+ | gene-YJL050W_VR1 | rna-NM_001181483.1_VR1 | cds-NP_012485.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:315534-318755:+ | gene-YJL050W_ZTW1 | rna-NM_001181483.1_ZTW1 | cds-NP_012485.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:339542-342769:+ | gene-YJL050W_Sparadoxus | rna-NM_001181483.1_Sparadoxus | cds-NP_012485.1_Sparadoxus | 91.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |