Gene name: MTH1
Reference locus (S288C): YDR277C
Gene biotype: protein_coding
Description: Protein MTH1; Negative regulator of the glucose-sensing signal transduction pathway; required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation; MTH1 has a paralog, STD1, that arose from the whole genome duplication
Top 10 interactors (score): RGT1 (0.928); SNF3 (0.892); RGT2 (0.86); STD1 (0.778); HAP2 (0.777); HXT2 (0.76); HAP3 (0.754); BCP1 (0.746); HXT1 (0.746); GRR1 (0.646); HXT3 (0.637); YPL264C (0.534); HXT4 (0.533); PYC1 (0.509); PYC2 (0.498); GPR1 (0.472); TUP1 (0.471); HAP5 (0.468); HXT6 (0.463); HXT7 (0.462)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:966712-968013:- | gene-YDR277C_AKU4011 | rna-NM_001180585.3_AKU4011 | cds-NP_010563.3_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:164318-165619:+ | gene-YDR277C_BG1 | rna-NM_001180585.3_BG1 | cds-NP_010563.3_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:992854-994155:- | gene-YDR277C_Bruggeman | rna-NM_001180585.3_Bruggeman | cds-NP_010563.3_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:980993-982294:- | gene-YDR277C_CAT1 | rna-NM_001180585.3_CAT1 | cds-NP_010563.3_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:961157-962458:- | gene-YDR277C_CBS1585 | rna-NM_001180585.3_CBS1585 | cds-NP_010563.3_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:979174-980475:- | gene-YDR277C_CBS436 | rna-NM_001180585.3_CBS436 | cds-NP_010563.3_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:957840-959141:- | gene-YDR277C_CBS6412 | rna-NM_001180585.3_CBS6412 | cds-NP_010563.3_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:979076-980377:- | gene-YDR277C_CBS6413 | rna-NM_001180585.3_CBS6413 | cds-NP_010563.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1013047-1014348:- | gene-YDR277C_CENPK1137D | rna-NM_001180585.3_CENPK1137D | cds-NP_010563.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:965256-966557:- | gene-YDR277C_EthanolRed | rna-NM_001180585.3_EthanolRed | cds-NP_010563.3_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:973458-974759:- | gene-YDR277C_FaliES1 | rna-NM_001180585.3_FaliES1 | cds-NP_010563.3_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000176.1:21714-23015:- | gene-YDR277C_JAY291 | rna-NM_001180585.3_JAY291 | cds-NP_010563.3_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:978900-980201:- | gene-YDR277C_MUCL30387 | rna-NM_001180585.3_MUCL30387 | cds-NP_010563.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:966213-967514:- | gene-YDR277C_MUCL30388 | rna-NM_001180585.3_MUCL30388 | cds-NP_010563.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:952963-954264:- | gene-YDR277C_MUCL39482 | rna-NM_001180585.3_MUCL39482 | cds-NP_010563.3_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:892942-894243:- | gene-YDR277C_MUCL42920 | rna-NM_001180585.3_MUCL42920 | cds-NP_010563.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1014324-1015625:- | gene-YDR277C_NCIM3186 | rna-NM_001180585.3_NCIM3186 | cds-NP_010563.3_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:966253-967554:- | gene-YDR277C_NCYC1407 | rna-NM_001180585.3_NCYC1407 | cds-NP_010563.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:976904-978205:- | gene-YDR277C_PE2H3 | rna-NM_001180585.3_PE2H3 | cds-NP_010563.3_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:982157-983458:- | gene-YDR277C_PE2H4 | rna-NM_001180585.3_PE2H4 | cds-NP_010563.3_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1014401-1015702:- | gene-YDR277C_S288C | rna-NM_001180585.3_S288C | cds-NP_010563.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000102.1:22040-23341:- | gene-YDR277C_SA1 | rna-NM_001180585.3_SA1 | cds-NP_010563.3_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:977743-979044:- | gene-YDR277C_ThermosaccDry | rna-NM_001180585.3_ThermosaccDry | cds-NP_010563.3_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:993339-994640:- | gene-YDR277C_VR1 | rna-NM_001180585.3_VR1 | cds-NP_010563.3_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:21868-23169:- | gene-YDR277C_ZTW1 | rna-NM_001180585.3_ZTW1 | cds-NP_010563.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:974162-975463:- | gene-YDR277C_Sparadoxus | rna-NM_001180585.3_Sparadoxus | cds-NP_010563.3_Sparadoxus | 91.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |