Gene name: MTD1
Reference locus (S288C): YKR080W
Gene biotype: protein_coding
Description: Methylenetetrahydrofolate dehydrogenase [NAD(+)]; NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase; plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
Top 10 interactors (score): SHM2 (0.999); GCV1 (0.998); GCV2 (0.992); GCV3 (0.985); SHM1 (0.981); ADE17 (0.98); FAU1 (0.977); ADE8 (0.977); MET13 (0.975); ADE13 (0.971); MET12 (0.969); CDC21 (0.967); ADE3 (0.951); MIS1 (0.944); LPD1 (0.921); ADE4 (0.917); ADE5,7 (0.895); GUA1 (0.868); ADE16 (0.844); SER1 (0.836)
Homologues (species, bitscore): MTHFD2 (Homo sapiens, 77.0); Mthfd2l (Mus musculus, 77.4); mthfd2 (Danio rerio, 75.9); mthfd2l (Xenopus tropicalis, 77.4); Nmdmc (Drosophila melanogaster, 66.2); dao-3 (Caenorhabditis elegans, 62.4); EMB3127 (Arabidopsis thaliana, 79.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:576425-577387:+ | gene-YKR080W_AKU4011 | rna-NM_001179870.3_AKU4011 | cds-NP_013006.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000113.1:66838-67800:- | gene-YKR080W_BG1 | rna-NM_001179870.3_BG1 | cds-NP_013006.3_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:599003-599965:+ | gene-YKR080W_Bruggeman | rna-NM_001179870.3_Bruggeman | cds-NP_013006.3_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:594924-595886:+ | gene-YKR080W_CAT1 | rna-NM_001179870.3_CAT1 | cds-NP_013006.3_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:588912-589874:+ | gene-YKR080W_CBS1585 | rna-NM_001179870.3_CBS1585 | cds-NP_013006.3_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:587297-588259:+ | gene-YKR080W_CBS436 | rna-NM_001179870.3_CBS436 | cds-NP_013006.3_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:572200-573162:+ | gene-YKR080W_CBS6412 | rna-NM_001179870.3_CBS6412 | cds-NP_013006.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:588730-589692:+ | gene-YKR080W_CBS6413 | rna-NM_001179870.3_CBS6413 | cds-NP_013006.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:590050-591012:+ | gene-YKR080W_CENPK1137D | rna-NM_001179870.3_CENPK1137D | cds-NP_013006.3_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:586236-587198:+ | gene-YKR080W_EthanolRed | rna-NM_001179870.3_EthanolRed | cds-NP_013006.3_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:590131-591093:+ | gene-YKR080W_FaliES1 | rna-NM_001179870.3_FaliES1 | cds-NP_013006.3_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000426.1:53840-54802:- | gene-YKR080W_JAY291 | rna-NM_001179870.3_JAY291 | cds-NP_013006.3_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:598499-599461:+ | gene-YKR080W_MUCL30387 | rna-NM_001179870.3_MUCL30387 | cds-NP_013006.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:592842-593804:+ | gene-YKR080W_MUCL30388 | rna-NM_001179870.3_MUCL30388 | cds-NP_013006.3_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:587753-588715:+ | gene-YKR080W_MUCL39482 | rna-NM_001179870.3_MUCL39482 | cds-NP_013006.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:593776-594738:+ | gene-YKR080W_MUCL42920 | rna-NM_001179870.3_MUCL42920 | cds-NP_013006.3_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:590384-591346:+ | gene-YKR080W_NCIM3186 | rna-NM_001179870.3_NCIM3186 | cds-NP_013006.3_NCIM3186 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:588165-589127:+ | gene-YKR080W_NCYC1407 | rna-NM_001179870.3_NCYC1407 | cds-NP_013006.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:613331-614293:+ | gene-YKR080W_PE2H3 | rna-NM_001179870.3_PE2H3 | cds-NP_013006.3_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:597735-598697:+ | gene-YKR080W_PE2H4 | rna-NM_001179870.3_PE2H4 | cds-NP_013006.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:590395-591357:+ | gene-YKR080W_S288C | rna-NM_001179870.3_S288C | cds-NP_013006.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000029.1:90492-91454:- | gene-YKR080W_SA1 | rna-NM_001179870.3_SA1 | cds-NP_013006.3_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:589378-590340:+ | gene-YKR080W_ThermosaccDry | rna-NM_001179870.3_ThermosaccDry | cds-NP_013006.3_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:588641-589603:+ | gene-YKR080W_VR1 | rna-NM_001179870.3_VR1 | cds-NP_013006.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:586360-587322:+ | gene-YKR080W_ZTW1 | rna-NM_001179870.3_ZTW1 | cds-NP_013006.3_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:611610-612572:+ | gene-YKR080W_Sparadoxus | rna-NM_001179870.3_Sparadoxus | cds-NP_013006.3_Sparadoxus | 93.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |