Gene name: MTC5
Reference locus (S288C): YDR128W
Gene biotype: protein_coding
Description: Maintenance of telomere capping protein 5; Subunit of SEACAT, a subcomplex of the SEA complex; Mtc1p, along with Rtc1p and Sea4p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; relative distribution to the vacuolar membrane decreases upon DNA replication stress
Top 10 interactors (score): RTC1 (0.999); NPR2 (0.999); SEH1 (0.999); SEC13 (0.999); IML1 (0.999); SEA4 (0.999); NPR3 (0.987); LST7 (0.946); GTR2 (0.902); GTR1 (0.902); LST4 (0.809); RHB1 (0.801); SLM4 (0.788); MEH1 (0.722); YNR021W (0.716); EGO2 (0.7); VAM6 (0.695); MAP2 (0.678); ATG13 (0.66); NUP85 (0.66)
Homologues (species, bitscore): WDR59 (Homo sapiens, 256.9); Wdr59 (Mus musculus, 257.3); wdr59 (Danio rerio, 229.9); wdr59 (Xenopus tropicalis, 236.9); CG4705 (Drosophila melanogaster, 186.4); lin-53 (Caenorhabditis elegans, 61.6); PEX7 (Arabidopsis thaliana, 62.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:680485-683931:+ | gene-YDR128W_AKU4011 | rna-NM_001180436.3_AKU4011 | cds-NP_010413.3_AKU4011 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:440937-444383:- | gene-YDR128W_BG1 | rna-NM_001180436.3_BG1 | cds-NP_010413.3_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:712544-715990:+ | gene-YDR128W_Bruggeman | rna-NM_001180436.3_Bruggeman | cds-NP_010413.3_Bruggeman | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:699296-702742:+ | gene-YDR128W_CAT1 | rna-NM_001180436.3_CAT1 | cds-NP_010413.3_CAT1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:671523-674969:+ | gene-YDR128W_CBS1585 | rna-NM_001180436.3_CBS1585 | cds-NP_010413.3_CBS1585 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:697412-700858:+ | gene-YDR128W_CBS436 | rna-NM_001180436.3_CBS436 | cds-NP_010413.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:667875-671321:+ | gene-YDR128W_CBS6412 | rna-NM_001180436.3_CBS6412 | cds-NP_010413.3_CBS6412 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:696851-700297:+ | gene-YDR128W_CBS6413 | rna-NM_001180436.3_CBS6413 | cds-NP_010413.3_CBS6413 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:701990-705436:+ | gene-YDR128W_CENPK1137D | rna-NM_001180436.3_CENPK1137D | cds-NP_010413.3_CENPK1137D | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:682248-685694:+ | gene-YDR128W_EthanolRed | rna-NM_001180436.3_EthanolRed | cds-NP_010413.3_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:689042-692488:+ | gene-YDR128W_FaliES1 | rna-NM_001180436.3_FaliES1 | cds-NP_010413.3_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000002.1:41171-44617:+ | gene-YDR128W_JAY291 | rna-NM_001180436.3_JAY291 | cds-NP_010413.3_JAY291 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:698468-701914:+ | gene-YDR128W_MUCL30387 | rna-NM_001180436.3_MUCL30387 | cds-NP_010413.3_MUCL30387 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:687487-690933:+ | gene-YDR128W_MUCL30388 | rna-NM_001180436.3_MUCL30388 | cds-NP_010413.3_MUCL30388 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:672866-676312:+ | gene-YDR128W_MUCL39482 | rna-NM_001180436.3_MUCL39482 | cds-NP_010413.3_MUCL39482 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:610814-614260:+ | gene-YDR128W_MUCL42920 | rna-NM_001180436.3_MUCL42920 | cds-NP_010413.3_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:709472-712918:+ | gene-YDR128W_NCIM3186 | rna-NM_001180436.3_NCIM3186 | cds-NP_010413.3_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:672269-675715:+ | gene-YDR128W_NCYC1407 | rna-NM_001180436.3_NCYC1407 | cds-NP_010413.3_NCYC1407 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:691600-695046:+ | gene-YDR128W_PE2H3 | rna-NM_001180436.3_PE2H3 | cds-NP_010413.3_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:690905-694351:+ | gene-YDR128W_PE2H4 | rna-NM_001180436.3_PE2H4 | cds-NP_010413.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:709549-712995:+ | gene-YDR128W_S288C | rna-NM_001180436.3_S288C | cds-NP_010413.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000009.1:58216-61662:+ | gene-YDR128W_SA1 | rna-NM_001180436.3_SA1 | cds-NP_010413.3_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:688564-692010:+ | gene-YDR128W_ThermosaccDry | rna-NM_001180436.3_ThermosaccDry | cds-NP_010413.3_ThermosaccDry | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:701914-705360:+ | gene-YDR128W_VR1 | rna-NM_001180436.3_VR1 | cds-NP_010413.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:686149-689596:+ | gene-YDR128W_ZTW1 | rna-NM_001180436.3_ZTW1 | cds-NP_010413.3_ZTW1 | 99.1 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:690650-694096:+ | gene-YDR128W_Sparadoxus | rna-NM_001180436.3_Sparadoxus | cds-NP_010413.3_Sparadoxus | 90.2 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |