Gene name: MSH2
Reference locus (S288C): YOL090W
Gene biotype: protein_coding
Description: Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP
Top 10 interactors (score): PMS1 (0.999); MLH1 (0.999); POL3 (0.999); MSH3 (0.999); POL30 (0.999); MSH6 (0.999); EXO1 (0.999); POL2 (0.998); MLH3 (0.997); RAD10 (0.997); RAD1 (0.997); RAD27 (0.996); RFA1 (0.992); DIN7 (0.992); RAD52 (0.988); RAD14 (0.987); MCM2 (0.985); SMC3 (0.984); RAD2 (0.983); SGS1 (0.981)
Homologues (species, bitscore): MSH2 (Homo sapiens, 705.7); Msh2 (Mus musculus, 700.3); msh2 (Danio rerio, 675.2); msh2 (Xenopus tropicalis, 642.9); spel1 (Drosophila melanogaster, 544.3); msh-2 (Caenorhabditis elegans, 371.7); MSH2 (Arabidopsis thaliana, 592.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:130729-133623:+ | gene-YOL090W_AKU4011 | rna-NM_001183344.1_AKU4011 | cds-NP_014551.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000172.1:95834-98728:+ | gene-YOL090W_BG1 | rna-NM_001183344.1_BG1 | cds-NP_014551.1_BG1 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:132278-135172:+ | gene-YOL090W_Bruggeman | rna-NM_001183344.1_Bruggeman | cds-NP_014551.1_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:131609-134503:+ | gene-YOL090W_CAT1 | rna-NM_001183344.1_CAT1 | cds-NP_014551.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:125141-128035:+ | gene-YOL090W_CBS1585 | rna-NM_001183344.1_CBS1585 | cds-NP_014551.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:130415-133309:+ | gene-YOL090W_CBS436 | rna-NM_001183344.1_CBS436 | cds-NP_014551.1_CBS436 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:125297-128191:+ | gene-YOL090W_CBS6412 | rna-NM_001183344.1_CBS6412 | cds-NP_014551.1_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:132004-134898:+ | gene-YOL090W_CBS6413 | rna-NM_001183344.1_CBS6413 | cds-NP_014551.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:141347-144241:+ | gene-YOL090W_CENPK1137D | rna-NM_001183344.1_CENPK1137D | cds-NP_014551.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:128302-131196:+ | gene-YOL090W_EthanolRed | rna-NM_001183344.1_EthanolRed | cds-NP_014551.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:130629-133523:+ | gene-YOL090W_FaliES1 | rna-NM_001183344.1_FaliES1 | cds-NP_014551.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000160.1:9951-12845:- | gene-YOL090W_JAY291 | rna-NM_001183344.1_JAY291 | cds-NP_014551.1_JAY291 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:136481-139375:+ | gene-YOL090W_MUCL30387 | rna-NM_001183344.1_MUCL30387 | cds-NP_014551.1_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:139661-142555:+ | gene-YOL090W_MUCL30388 | rna-NM_001183344.1_MUCL30388 | cds-NP_014551.1_MUCL30388 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:133062-135956:+ | gene-YOL090W_MUCL39482 | rna-NM_001183344.1_MUCL39482 | cds-NP_014551.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:148830-151724:+ | gene-YOL090W_MUCL42920 | rna-NM_001183344.1_MUCL42920 | cds-NP_014551.1_MUCL42920 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:147271-150165:+ | gene-YOL090W_NCIM3186 | rna-NM_001183344.1_NCIM3186 | cds-NP_014551.1_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:139657-142551:+ | gene-YOL090W_NCYC1407 | rna-NM_001183344.1_NCYC1407 | cds-NP_014551.1_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:122952-125846:+ | gene-YOL090W_PE2H3 | rna-NM_001183344.1_PE2H3 | cds-NP_014551.1_PE2H3 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:133936-136830:+ | gene-YOL090W_PE2H4 | rna-NM_001183344.1_PE2H4 | cds-NP_014551.1_PE2H4 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:147382-150276:+ | gene-YOL090W_S288C | rna-NM_001183344.1_S288C | cds-NP_014551.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000001.1:115262-118156:+ | gene-YOL090W_SA1 | rna-NM_001183344.1_SA1 | cds-NP_014551.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:129637-132531:+ | gene-YOL090W_ThermosaccDry | rna-NM_001183344.1_ThermosaccDry | cds-NP_014551.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:130203-133097:+ | gene-YOL090W_VR1 | rna-NM_001183344.1_VR1 | cds-NP_014551.1_VR1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000031.1:129335-132229:+ | gene-YOL090W_ZTW1 | rna-NM_001183344.1_ZTW1 | cds-NP_014551.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:132786-135680:+ | gene-YOL090W_Sparadoxus | rna-NM_001183344.1_Sparadoxus | cds-NP_014551.1_Sparadoxus | 90.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |