Gene name: MSB4
Reference locus (S288C): YOL112W
Gene biotype: protein_coding
Description: GTPase-activating protein of the Ras superfamily; acts primarily on Sec4p, localizes to the bud site and bud tip; msb3 msb4 double mutation causes defects in secretion and actin organization; similar to the TBC-domain Tre2 oncogene; MSB4 has a paralog, MSB3, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null mutant
Top 10 interactors (score): SPA2 (0.994); BUD6 (0.981); BNI1 (0.978); MSB3 (0.977); PEA2 (0.971); SEC4 (0.918); CDC42 (0.901); GYP1 (0.9); YPT7 (0.884); GYP7 (0.874); GYL1 (0.795); GYP8 (0.791); VPS21 (0.744); YPT31 (0.732); GIC1 (0.712); YPT32 (0.703); SEC2 (0.689); YPT6 (0.684); YPT1 (0.659); THP1 (0.658)
Homologues (species, bitscore): GRTP1 (Homo sapiens, 177.6); Grtp1 (Mus musculus, 175.6); grtp1b (Danio rerio, 185.3); grtp1 (Xenopus tropicalis, 184.5); CG7324 (Drosophila melanogaster, 145.2); tbc-9 (Caenorhabditis elegans, 146.4); AT2G37290 (Arabidopsis thaliana, 134.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:95352-96830:+ | gene-YOL112W_AKU4011 | rna-NM_001183366.1_AKU4011 | cds-NP_014529.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000172.1:60984-62462:+ | gene-YOL112W_BG1 | rna-NM_001183366.1_BG1 | cds-NP_014529.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:96627-98105:+ | gene-YOL112W_Bruggeman | rna-NM_001183366.1_Bruggeman | cds-NP_014529.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:95822-97300:+ | gene-YOL112W_CAT1 | rna-NM_001183366.1_CAT1 | cds-NP_014529.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:89826-91304:+ | gene-YOL112W_CBS1585 | rna-NM_001183366.1_CBS1585 | cds-NP_014529.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:95666-97144:+ | gene-YOL112W_CBS436 | rna-NM_001183366.1_CBS436 | cds-NP_014529.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:89690-91168:+ | gene-YOL112W_CBS6412 | rna-NM_001183366.1_CBS6412 | cds-NP_014529.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:96158-97636:+ | gene-YOL112W_CBS6413 | rna-NM_001183366.1_CBS6413 | cds-NP_014529.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:106605-108083:+ | gene-YOL112W_CENPK1137D | rna-NM_001183366.1_CENPK1137D | cds-NP_014529.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:93624-95102:+ | gene-YOL112W_EthanolRed | rna-NM_001183366.1_EthanolRed | cds-NP_014529.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:95653-97131:+ | gene-YOL112W_FaliES1 | rna-NM_001183366.1_FaliES1 | cds-NP_014529.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000203.1:12864-14342:+ | gene-YOL112W_JAY291 | rna-NM_001183366.1_JAY291 | cds-NP_014529.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:101269-102747:+ | gene-YOL112W_MUCL30387 | rna-NM_001183366.1_MUCL30387 | cds-NP_014529.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:104272-105750:+ | gene-YOL112W_MUCL30388 | rna-NM_001183366.1_MUCL30388 | cds-NP_014529.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:97765-99243:+ | gene-YOL112W_MUCL39482 | rna-NM_001183366.1_MUCL39482 | cds-NP_014529.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:113898-115376:+ | gene-YOL112W_MUCL42920 | rna-NM_001183366.1_MUCL42920 | cds-NP_014529.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:106599-108077:+ | gene-YOL112W_NCIM3186 | rna-NM_001183366.1_NCIM3186 | cds-NP_014529.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:103799-105277:+ | gene-YOL112W_NCYC1407 | rna-NM_001183366.1_NCYC1407 | cds-NP_014529.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:82264-83742:+ | gene-YOL112W_PE2H3 | rna-NM_001183366.1_PE2H3 | cds-NP_014529.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:99193-100671:+ | gene-YOL112W_PE2H4 | rna-NM_001183366.1_PE2H4 | cds-NP_014529.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:106710-108188:+ | gene-YOL112W_S288C | rna-NM_001183366.1_S288C | cds-NP_014529.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000001.1:80137-81615:+ | gene-YOL112W_SA1 | rna-NM_001183366.1_SA1 | cds-NP_014529.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:94791-96269:+ | gene-YOL112W_ThermosaccDry | rna-NM_001183366.1_ThermosaccDry | cds-NP_014529.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:95442-96920:+ | gene-YOL112W_VR1 | rna-NM_001183366.1_VR1 | cds-NP_014529.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000031.1:94515-95993:+ | gene-YOL112W_ZTW1 | rna-NM_001183366.1_ZTW1 | cds-NP_014529.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:97300-98778:+ | gene-YOL112W_Sparadoxus | rna-NM_001183366.1_Sparadoxus | cds-NP_014529.1_Sparadoxus | 90.6 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |