Gene name: MSB3
Reference locus (S288C): YNL293W
Gene biotype: protein_coding
Description: Rab GTPase-activating protein; regulates endocytosis via inactivation of Vps21p at endosomes and vacuole fusion via inactivation of Ypt7p at vacuoles; also acts on Ypt52p and Sec4p; localizes to plasma membrane, sites of polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; similar to TBC-domain Tre2 oncogene; MSB3 has a paralog, MSB4, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null
Top 10 interactors (score): SPA2 (0.994); BUD6 (0.987); BNI1 (0.986); PEA2 (0.981); MSB4 (0.977); SEC4 (0.967); CDC42 (0.956); YPT7 (0.948); VPS21 (0.938); BLI1 (0.911); GYP1 (0.903); YPT52 (0.867); GYP7 (0.865); VPS9 (0.856); MON1 (0.85); YPT6 (0.828); YPT31 (0.828); SNN1 (0.822); YPT53 (0.798); GYP8 (0.791)
Homologues (species, bitscore): GRTP1 (Homo sapiens, 179.1); Grtp1 (Mus musculus, 170.2); grtp1b (Danio rerio, 189.1); grtp1 (Xenopus tropicalis, 175.3); CG5916 (Drosophila melanogaster, 144.1); tbc-9 (Caenorhabditis elegans, 141.0); AT2G37290 (Arabidopsis thaliana, 137.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:74453-76354:+ | gene-YNL293W_AKU4011 | rna-NM_001183131.1_AKU4011 | cds-NP_014106.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000074.1:14290-16191:- | gene-YNL293W_BG1 | rna-NM_001183131.1_BG1 | cds-NP_014106.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:83799-85700:+ | gene-YNL293W_Bruggeman | rna-NM_001183131.1_Bruggeman | cds-NP_014106.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:86404-88305:+ | gene-YNL293W_CAT1 | rna-NM_001183131.1_CAT1 | cds-NP_014106.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:74784-76685:+ | gene-YNL293W_CBS1585 | rna-NM_001183131.1_CBS1585 | cds-NP_014106.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:75274-77175:+ | gene-YNL293W_CBS436 | rna-NM_001183131.1_CBS436 | cds-NP_014106.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:71441-73342:+ | gene-YNL293W_CBS6412 | rna-NM_001183131.1_CBS6412 | cds-NP_014106.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:71632-73533:+ | gene-YNL293W_CBS6413 | rna-NM_001183131.1_CBS6413 | cds-NP_014106.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:74473-76374:+ | gene-YNL293W_CENPK1137D | rna-NM_001183131.1_CENPK1137D | cds-NP_014106.1_CENPK1137D | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:71472-73373:+ | gene-YNL293W_EthanolRed | rna-NM_001183131.1_EthanolRed | cds-NP_014106.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:72371-74272:+ | gene-YNL293W_FaliES1 | rna-NM_001183131.1_FaliES1 | cds-NP_014106.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000171.1:13945-15846:- | gene-YNL293W_JAY291 | rna-NM_001183131.1_JAY291 | cds-NP_014106.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:84299-86200:+ | gene-YNL293W_MUCL30387 | rna-NM_001183131.1_MUCL30387 | cds-NP_014106.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:77079-78980:+ | gene-YNL293W_MUCL30388 | rna-NM_001183131.1_MUCL30388 | cds-NP_014106.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:72418-74319:+ | gene-YNL293W_MUCL39482 | rna-NM_001183131.1_MUCL39482 | cds-NP_014106.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:74110-76011:+ | gene-YNL293W_MUCL42920 | rna-NM_001183131.1_MUCL42920 | cds-NP_014106.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:80609-82510:+ | gene-YNL293W_NCIM3186 | rna-NM_001183131.1_NCIM3186 | cds-NP_014106.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:73750-75651:+ | gene-YNL293W_NCYC1407 | rna-NM_001183131.1_NCYC1407 | cds-NP_014106.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:70949-72850:+ | gene-YNL293W_PE2H3 | rna-NM_001183131.1_PE2H3 | cds-NP_014106.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:70337-72238:+ | gene-YNL293W_PE2H4 | rna-NM_001183131.1_PE2H4 | cds-NP_014106.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:80640-82541:+ | gene-YNL293W_S288C | rna-NM_001183131.1_S288C | cds-NP_014106.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000052.1:14676-16577:- | gene-YNL293W_SA1 | rna-NM_001183131.1_SA1 | cds-NP_014106.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:73228-75129:+ | gene-YNL293W_ThermosaccDry | rna-NM_001183131.1_ThermosaccDry | cds-NP_014106.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:85769-87670:+ | gene-YNL293W_VR1 | rna-NM_001183131.1_VR1 | cds-NP_014106.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000029.1:64439-66340:+ | gene-YNL293W_ZTW1 | rna-NM_001183131.1_ZTW1 | cds-NP_014106.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:82501-84399:+ | gene-YNL293W_Sparadoxus | rna-NM_001183131.1_Sparadoxus | cds-NP_014106.1_Sparadoxus | 90.8 | 99.5 | Verified | 1 | 1 | 1 | False | True | False | False | False |